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Author Details

Matthew P Crump
University of Bristol
1996
121
37
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36314667The Role of Cytochromeâ¿¿P450 AbyV in the Final Stages of Abyssomicinâ¿¿C Biosynthesis.Angew Chem Int Ed Engl2023
37487099An expandable, modular de novo protein platform for precision redox engineering.Proc Natl Acad Sci U S A2023
37768840Structure and Function of the α-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.Angew Chem Int Ed Engl2023
37218580Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents.Angew Chem Int Ed Engl2023
35029626Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans.Org Biomol Chem2022
35557750Path to Actinorhodin: Regio- and Stereoselective Ketone Reduction by a Type II Polyketide Ketoreductase Revealed in Atomistic Detail.JACS Au2022
36227272Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin.Angew Chem Int Ed Engl2022
33416314Solution Structure and Conformational Dynamics of a Doublet Acyl Carrier Protein from Prodigiosin Biosynthesis.Biochemistry2021
33750792Structural resolution of switchable states of a de novo peptide assembly.Nat Commun2021
34758357The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compound UCN-01.J Biol Chem2021
34321209Molecular mechanism for kinesin-1 direct membrane recognition.Sci Adv2021
34190301Ambruticins: tetrahydropyran ring formation and total synthesis.Org Biomol Chem2021
33057534Polyketide β-branching: diversity, mechanism and selectivity.Nat Prod Rep2021
33043457SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase.FEBS Lett2021
32229583The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture.J Biol Chem2020
34122978Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics.Chem Sci2020
31977176A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis.ACS Chem Biol2020
32806153Total Synthesis of Kalimantacin A.Org Lett2020
32938984Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein.Sci Rep2020
32877646Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.Structure2020
32208550The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.Angew Chem Int Ed Engl2020
30640473Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking.J Med Chem2019
31294525Control of β-Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup> C⿿NMR to Polyketide Programming.Angew Chem Int Ed Engl2019
31251570Stabilizing and Understanding a Miniprotein by Rational Redesign.Biochemistry2019
31095849The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor.Angew Chem Int Ed Engl2019
30733464Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586.Sci Rep2019
30420776A biomimetic receptor for glucose.Nat Chem2019
29161022Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.ACS Chem Biol2018
30118604Practical Considerations in High-Precision Compound-Specific Radiocarbon Analyses: Eliminating the Effects of Solvent and Sample Cross-Contamination on Accuracy and Precision.Anal Chem2018
30337369The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA.J Biol Chem2018
30275547The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity.Sci Rep2018
29620883An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.J Am Chem Soc2018
28842561Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme.Nat Commun2017
28181382Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.Angew Chem Int Ed Engl2017
28989652Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics.Chem Sci2017
29244022The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere.Elife2017
28626561Enantioselective carbohydrate recognition by synthetic lectins in water.Chem Sci2017
28557447Use of a 700 MHz NMR Microcryoprobe for the Identification and Quantification of Exogenous Carbon in Compounds Purified by Preparative Capillary Gas Chromatography for Radiocarbon Determinations.Anal Chem2017
28530710Engineering protein stability with atomic precision in a monomeric miniprotein.Nat Chem Biol2017
26786502Synthesis and evaluation of a desymmetrised synthetic lectin: an approach to carbohydrate receptors with improved versatility.Org Biomol Chem2016
28936328Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein.Chem Sci2016
26673266A threading receptor for polysaccharides.Nat Chem2016
26469746Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria.Nat Prod Res2016
27140600Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.Proc Natl Acad Sci U S A2016
27312071Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water.Angew Chem Int Ed Engl2016
27510031Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.J Biol Chem2016
26822115Synthetic Receptors for the High-Affinity Recognition of O-GlcNAc Derivatives.Angew Chem Int Ed Engl2016
25454499Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery.J Med Chem2015
32262908Structure and function of the silicifying peptide R5.J Mater Chem B2015
26284676Corrigendum: Local and macroscopic electrostatic interactions in single α-helices.Nat Chem Biol2015
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Collaborators

Ulrich L G??nther
Institute of Chemistry and Metabolomics, University of Lubeck
Co-authored papers 3
Geert-Jan Boons
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Ray Luo
Co-authored papers 1
Michael R Gryk
University of Illinois
Co-authored papers 1
Walter J Chazin
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Bernd Reif
Technische Universitat Munchen (TUM)
Co-authored papers 1
Alexander P Golovanov
The University of Manchester
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Gordon C K Roberts
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Mike P Williamson
The University of Sheffield
Co-authored papers 1
Lu-Yun Lian
Institute of Systems, The University of Liverpool
Co-authored papers 1
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Thomas A Frenkiel
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
Ernest D Laue
University of Cambridge
Co-authored papers 1
Gordon S Rule
Carnegie Mellon University
Co-authored papers 1
Stephen Matthews
Imperial College London
Co-authored papers 1
Chien Ho
Carnegie Mellon University
Co-authored papers 1
Toshimichi Fujiwara
Institute for Protein Research, Osaka University
Co-authored papers 1
Pei Tang
Sichuan University
Co-authored papers 1
Joern Werner
Co-authored papers 1
Paul C Driscoll
The Francis Crick Institute
Co-authored papers 1
Shigeyuki Yokoyama
Shinshu University School of Medicine
Co-authored papers 1
Release 1.2