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Author Details

Dylan J Taatjes
University of Colorado
1996
81
42
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37461585Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome.bioRxiv2024
36631611An atlas of substrate specificities for the human serine/threonine kinome.Nature2023
34474085Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription.J Mol Biol2022
35725906The Mediator complex as a master regulator of transcription by RNA polymerase II.Nat Rev Mol Cell Biol2022
35385747Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide.Cell Rep2022
36041630Systematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6.J Biol Chem2022
35926294Chemical inhibitors of transcription-associated kinases.Curr Opin Chem Biol2022
36055203SnapShot: Mediator complex structure.Cell2022
33453189The Role of XPB/Ssl2 dsDNA Translocase Processivity in Transcription Start-site Scanning.J Mol Biol2021
34079046Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment.Commun Biol2021
34131334Everything at once: cryo-EM yields remarkable insights into human RNA polymerase II transcription.Nat Struct Mol Biol2021
34351910The ο40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation.PLoS Biol2021
33957145RNA Polymerase II Transcription.J Mol Biol2021
32229306TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.Mol Cell2020
33060135Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.Genes Dev2020
32554597Partitioning of cancer therapeutics in nuclear condensates.Science2020
32238450Structure and mechanism of the RNA polymerase II transcription machinery.Genes Dev2020
30585107Regulatory functions of the Mediator kinases CDK8 and CDK19.Transcription2019
31495563Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.Mol Cell2019
31563432Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.Mol Cell2019
31391587Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.Nature2019
31024071The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.Sci Rep2019
28912271The complex structure and function of Mediator.J Biol Chem2018
29895907Transcription regulation enters a new phase.Nature2018
30449618Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.Cell2018
29664212The essential and multifunctional TFIIH complex.Protein Sci2018
28716626Transcription Factor-Mediator Interfaces: Multiple and Multi-Valent.J Mol Biol2017
28370550Studying transcription initiation by RNA polymerase with diffusion-based single-molecule fluorescence.Protein Sci2017
28416637A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.Mol Cell Biol2017
28985500The Continuing SAGA of TFIID and RNA Polymerase II Transcription.Mol Cell2017
28768201Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications.Cell Rep2017
27050516Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.Cell Rep2016
27729537Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase.Proc Natl Acad Sci U S A2016
27155574Macromolecular Complexes in Transcription and Co-Transcriptional RNA Processing.J Mol Biol2016
25794613All in the family: a portrait of a nuclear receptor co-activator complex.Mol Cell2015
26450052Molecular biology: Mediating transcription and RNA export.Nature2015
26340423Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH.Mol Cell2015
26416749Mediator kinase inhibition further activates super-enhancer-associated genes in AML.Nature2015
25693131The Mediator complex: a central integrator of transcription.Nat Rev Mol Cell Biol2015
24913192Mediator redefines itself.Cell Res2014
25173174TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.Nat Struct Mol Biol2014
23322298The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.Genes Dev2013
25705053Small molecule probes to target the human Mediator complex.Isr J Chem2013
24088064The Mediator complex and transcription regulation.Crit Rev Biochem Mol Biol2013
24145197οNp53 and aging.Aging (Albany NY)2013
23734707The human οNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function.Aging Cell2013
23446344Structural visualization of key steps in human transcription initiation.Nature2013
23417068Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.Nature2013
23352233CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.Immunity2013
22343046Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.J Mol Biol2012
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Collaborators

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University of Colorado
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Fred Hutchinson Cancer Center
Co-authored papers 2
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Meyer Cancer Center
Co-authored papers 2
Sergei Borukhov
Rowan University School of Osteopathic Medicine
Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Institut Pasteur
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University of California San Francisco
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Humboldt-Universitat zu Berlin
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University of California san francisco
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Dana-Farber Cancer Institute
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CNRS UMR 5086 and Universite Claude Bernard Lyon 1
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Meyer Cancer Center
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Case Western Reserve University
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Peter V Hornbeck
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Ali Shilatifard
Northwestern University Feinberg School of Medicine
Co-authored papers 1
Bong Kim
Institute for Systems Biology
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Scott A Armstrong
Boston Children's Hospital
Co-authored papers 1
Craig D Kaplan
University of Pittsburgh
Co-authored papers 1
Charles H Greenberg
University of California San Francisco
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Peter Cimermancic
Verily Life Sciences LLC
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Bin Zhang
Co-authored papers 1
Anthony A Hyman
Max Planck Institute of Molecular Cell Biology and Genetics
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Jie Luo
Institute for Systems Biology
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Ibrahim I Cisse
Massachusetts Institute of Technology (MIT)
Co-authored papers 1
Nathanael S Gray
Harvard Medical School
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Shruthi Viswanath
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Release 1.2