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Author Details

Daniel D De Carvalho
Princess Margaret Cancer Centre, University Health Network
2010
63
31
PMIDPaper TitleJournal TitlePublished Year
37726227Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia.Br J Haematol2024
36455236Cerebrospinal fluid methylome-based liquid biopsies for accurate malignant brain neoplasm classification.Neuro Oncol2023
37600767The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population.Front Immunol2023
37244935macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma.Nat Commun2023
35263585Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.Cell Rep2022
35578032PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.Nat Chem Biol2022
36425756Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction.iScience2022
36309516The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors.Nat Commun2022
35311997Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.Cancer Discov2022
33440135Spliceosome-Targeted Therapies Induce dsRNA Responses.Immunity2021
33654322Publisher Correction: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.Nature2021
33609448DNA hypomethylating agents increase activation and cytolytic activity of CD8<sup>+</sup> T cells.Mol Cell2021
34433969A clinically applicable integrative molecular classification of meningiomas.Nature2021
34649957Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis.Cancer Discov2021
33420488Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression.Nat Cell Biol2021
33242413The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization.Cell Stem Cell2021
31626871The role of DNA-demethylating agents in cancer therapy.Pharmacol Ther2020
33087935Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.Nature2020
32938917Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.Nat Commun2020
32992153Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.Eur J Cancer2020
32669707Nucleolar RNA polymerase II drives ribosome biogenesis.Nature2020
32753546An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors.J Immunother Cancer2020
32178828Using epigenetic data to estimate immune composition in admixed samples.Methods Enzymol2020
32546577Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.Cancer Discov2020
32299104Mitochondrial carrier homolog 2 is necessary for AML survival.Blood2020
31173706The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.Cell Stem Cell2019
31727248Methods to detect endogenous dsRNA induction and recognition.Methods Enzymol2019
30153961The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy.Trends Cell Biol2019
31526762Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.Cancer Cell2019
30926792Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.Nat Commun2019
30723290Epigenetic therapy in immune-oncology.Nat Rev Cancer2019
29760532Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.Nat Immunol2018
29937226LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.Cell2018
30064665Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer.Trends Cancer2018
29921600Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.J Cell Biol2018
30429608Sensitive tumour detection and classification using plasma cell-free DNA methylomes.Nature2018
28034915Early-life antibiotic treatment enhances the pathogenicity of CD4<sup>+</sup> T cells during intestinal inflammation.J Leukoc Biol2017
28150715Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage.Sci Rep2017
29580435Cell-free DNA as a post-treatment surveillance strategy: current status.Semin Oncol2017
28943328O-Acetylation of Peptidoglycan Limits Helper T Cell Priming and Permits Staphylococcus aureus Reinfection.Cell Host Microbe2017
29142897Drug-induced activation of "junk" DNA - A path to combat cancer therapy resistance?Oncoscience2017
29022901BCR-ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy.Cell Death Dis2017
26908456Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.Oncotarget2016
27960086Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.Cancer Cell2016
27424808Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Cancer Cell2016
26166478Symmetrical Dose-Dependent DNA-Methylation Profiles in Children with Deletion or Duplication of 7q11.23.Am J Hum Genet2015
26317465DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.Cell2015
27141349Pharmacological DNA demethylation: Implications for cancer immunotherapy.Oncoimmunology2015
26208902IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment.Cancer Res2015
24959746Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells.PLoS One2014
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Collaborators

Helen Loo Yau
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 13
Ankur Chakravarthy
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 13
Mathieu Lupien
Princess Margaret Cancer Research Centre
Co-authored papers 12
Tiago da Silva Medina
International Research Center, A.C.Camargo Cancer Center
Co-authored papers 10
Rajat Singhania
Virginia Polytechnic Institute and State University
Co-authored papers 9
Charles A Ishak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 8
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 8
Alex Murison
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 6
Gary D Bader
University of Toronto
Co-authored papers 6
Housheng Hansen He
Princess Margaret Cancer Center, University Health Network, University of Toronto
Co-authored papers 4
Sujun Chen
Princess Margaret Cancer Center/University Health Network
Co-authored papers 4
Trevor J Pugh
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
David W Cescon
Princess Margaret Cancer Centre
Co-authored papers 4
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 4
Genevi??ve Deblois
Institute for Research in Immunology and Cancer (IRIC), University of Montreal
Co-authored papers 3
Nada Jabado
McGill University Health Centre (MUHC), Montreal Children's Hospital (MCH)
Co-authored papers 3
Paul C Boutros
University of California los angeles
Co-authored papers 3
Paul Guilhamon
The Hospital for Sick Children
Co-authored papers 3
Ken J Kron
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 3
John E Dick
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Theodorus H van der Kwast
University Health Network, University of Toronto
Co-authored papers 2
Jennifer Cruickshank
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Farshad Nassiri
Toronto Western Hospital, University Health Network, University of Toronto
Co-authored papers 2
Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 2
Philippe L Bedard
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Wail Ba-Alawi
Princess Margaret Cancer Centre, University Health Network, University Ave.
Co-authored papers 2
Xianghong Jasmine Zhou
David Geffen School of Medicine, University of California at Los Angeles
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Marcela Gronda
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Michael Fraser
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Release 1.2