Author details

Full Name

Mario Niepel

Affiliation

ORCID

Career Start Year

1999

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37752135	PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNÎ³-driven acquired resistance in preclinical cancer models.	Nat Commun	2023
34323016	ADP-ribosyltransferases, an update on function and nomenclature.	FEBS J	2022
36376301	Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.	Nat Commun	2022
35817532	Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.	ImmunoHorizons	2022
34375612	PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.	Cancer Cell	2021
33705687	A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.	Cell Chem Biol	2021
33838082	Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.	ChemBioChem	2021
32679093	InÂ Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.	Cell Chemical Biology	2020
31961323	Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks.	eLife	2020
31812693	Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.	Cell Syst	2020
31864963	Maximum Entropy Framework for Predictive Inference of Cell Population Heterogeneity and Responses in Signaling Networks.		2020
30958184	Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer.	Journal of the Royal Society Interface	2019
31302153	A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines.	Cell Syst	2019
31075269	Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation.	Biochemical Pharmacology	2019
29199020	The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.	Cell Syst	2018
29065900	GRcalculator: an online tool for calculating and mining dose-response data.	BMC Cancer	2017
28591115	Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics.	Nat Biotechnol	2017
28628199	Measuring Cancer Drug Sensitivity and Resistance in Cultured Cells.	Curr Protoc Chem Biol	2017
28628201	Designing Drug-Response Experiments and Quantifying their Results.	Curr Protoc Chem Biol	2017
29084964	Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.	Nat Commun	2017
29112189	Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics.	Sci Data	2017
27405981	Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway.	Sci Signal	2016
28413689	L1000CDS<sup>2</sup>: LINCS L1000 characteristic direction signatures search engine.	NPJ Syst Biol Appl	2016
27135972	Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs.	Nat Methods	2016
25814555	Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.	Mol Syst Biol	2015
24655548	Analysis of growth factor signaling in genetically diverse breast cancer lines.	BMC Biol	2014
24906883	LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.	Nucleic Acids Res	2014
23607489	Mass spectrometry based method to increase throughput for kinome analyses using ATP probes.	Anal Chem	2013
23986566	Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE).	Bioinformatics	2013
24152732	The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome.	Mol Biol Cell	2013
24065145	Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines.	Sci Signal	2013
23436801	Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.	Cancer Res	2013
22223645	Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.	J Biol Chem	2012
22284361	Discovery of potent and selective covalent inhibitors of JNK.	Chem Biol	2012
21700874	A cell cycle phosphoproteome of the yeast centrosome.	Science	2011
21516115	Adaptive informatics for multifactorial and high-content biological data.	Nature Methods	2011
20520606	Dissecting variability in responses to cancer chemotherapy through systems pharmacology.	Clinical Pharmacology and Therapeutics	2010
20810646	Classic and contemporary approaches to modeling biochemical reactions.	Genes and Development	2010
20571586	The nuclear pore complex: bridging nuclear transport and gene regulation.	Nat Rev Mol Cell Biol	2010
19833543	Non-genetic cell-to-cell variability and the consequences for pharmacology.	Current Opinion in Chemical Biology	2009
19156131	Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.	Mol Syst Biol	2009
16027220	The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly.	J Cell Biol	2005
10908358	The role of 5'-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes.	Nucleic Acids Research	2000
10580096	Secondary structure in the 5'-leader or 3'-untranslated region reduces protein yield but does not affect the functional interaction between the 5'-cap and the poly(A) tail.	FEBS Letters	1999
10516014	Identification and characterization of the functional elements within the tobacco etch virus 5' leader required for cap-independent translation.	Journal of Virology	1999