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Author Details

Yan Xu
Nanjing Drum Tower Hospital
1990
115
32
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37402406Validity evidence for simulator-based obstetric ultrasound competency assessment tool: a multi-center study.Ultraschall Med2024
36821490Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization.ACS Chem Neurosci2023
37631904The Decay of Pertussis Antibodies in Children Aged 0-14 Years in Jiangsu Province, China.Vaccines (Basel)2023
37157155Value of synthetic MRI quantitative parameters in preprocedural evaluation for TRUS/MRI fusion-guided biopsy of the prostate.Prostate2023
35145092Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor.Nat Commun2022
36530663Seroepidemiology of pertussis in the east of China: Estimates of incidence of infection in adolescents and adults pre- and post-COVID-19.Front Public Health2022
34260401Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4-S5 linker in activation and slow inactivation.Proc Natl Acad Sci U S A2021
32191433A Thermal Place Preference Test for Discovery of Neuropathic Pain Drugs.ACS Chem Neurosci2020
31951367Functional Tolerance to Cysteine Mutations in Human α7 Nicotinic Acetylcholine Receptors.ACS Chem Neurosci2020
32608538Membrane cholesterol dependence of cannabinoid modulation of glycine receptor.FASEB J2020
31525026<sup>19</sup>F Paramagnetic Relaxation-Based NMR for Quaternary Structural Restraints of Ion Channels.ACS Chem Biol2019
29673527X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels.Methods Enzymol2018
30018039Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.J Gen Physiol2018
29896429Invasion of Peripheral Immune Cells into Brain Parenchyma after Cardiac Arrest and Resuscitation.Aging Dis2018
30266951Structural basis of neurosteroid anesthetic action on GABA<sub>A</sub> receptors.Nat Commun2018
29673534Solution NMR Studies of Anesthetic Interactions with Ion Channels.Methods Enzymol2018
27916519Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.Structure2017
28793215Ketamine Inhibition of the Pentameric Ligand-Gated Ion Channel GLIC.Biophys J2017
26756520Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.Anesthesiology2016
27628686Effects of Propofol General Anesthesia on Olfactory Relearning.Sci Rep2016
27856739Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac.Proc Natl Acad Sci U S A2016
27385587Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli.J Biol Chem2016
27286478Immune Modulation by Volatile Anesthetics.Anesthesiology2016
24680782Atomistic insights into human Cys-loop receptors by solution NMR.Biochim Biophys Acta2015
26382705Percolation Model of Sensory Transmission and Loss of Consciousness Under General Anesthesia.Phys Rev Lett2015
26346220Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.Sci Rep2015
25856773Dominant Alcohol-Protein Interaction via Hydration-Enabled Enthalpy-Driven Binding Mechanism.J Phys Chem B2015
25960405Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC.Structure2015
25790278Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.J Med Chem2015
24212198Facilitation of resident scholarly activity: strategy and outcome analyses using historical resident cohorts and a rank-to-match population.Anesthesiology2014
24695730ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.J Biol Chem2014
24694846Cellular registration without behavioral recall of olfactory sensory input under general anesthesia.Anesthesiology2014
24341978Photoaffinity labeling the propofol binding site in GLIC.Biochemistry2014
24384062NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites.Biochim Biophys Acta2014
22978431Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics.Biochem J2013
24050264Critical role of water in the binding of volatile anesthetics to proteins.J Phys Chem B2013
24194515Insights into distinct modulation of α7 and α7β2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane.J Biol Chem2013
23994010Open-channel structures of the human glycine receptor α1 full-length transmembrane domain.Structure2013
23965212Use of a problem-based learning discussion format to teach anesthesiology residents research fundamentals.J Clin Anesth2013
23667707Signal transduction pathways in the pentameric ligand-gated ion channels.PLoS One2013
23339564Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.J Am Chem Soc2013
23000369NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR.Biochim Biophys Acta2013
21669034Stem cells decreased neuronal cell death after hypoxic stress in primary fetal rat neurons in vitro.Cell Transplant2012
22958642Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine.Structure2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
22585736Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.J Exp Med2012
22395605Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine.Nat Commun2012
22361591NMR structures of the transmembrane domains of the α4β2 nAChR.Biochim Biophys Acta2012
22155685NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor.Biochim Biophys Acta2012
21460829Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.Nat Chem Biol2011
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Collaborators

Pei Tang
Sichuan University
Co-authored papers 94
Roderic G Eckenhoff
University of Pennsylvania, Perelman School of Medicine
Co-authored papers 8
Philip R Weinstein
University of California San Francisco
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Troy Wymore
Co-authored papers 1
Michael R Gryk
University of Illinois
Co-authored papers 1
Walter J Chazin
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Bernd Reif
Technische Universitat Munchen (TUM)
Co-authored papers 1
Matthew P Crump
University of Bristol
Co-authored papers 1
Alexander P Golovanov
The University of Manchester
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Gordon C K Roberts
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Mike P Williamson
The University of Sheffield
Co-authored papers 1
Lu-Yun Lian
Institute of Systems, The University of Liverpool
Co-authored papers 1
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Xinghua Lu
Co-authored papers 1
Thomas A Frenkiel
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
Kunhong Xiao
Co-authored papers 1
Ernest D Laue
University of Cambridge
Co-authored papers 1
Gordon S Rule
Carnegie Mellon University
Co-authored papers 1
Stephen Matthews
Imperial College London
Co-authored papers 1
Chien Ho
Carnegie Mellon University
Co-authored papers 1
Toshimichi Fujiwara
Institute for Protein Research, Osaka University
Co-authored papers 1
Release 1.2