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Author Details

Xandra O Breakefield
Massachusetts General Hospital
1973
466
108
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36907561Engineered EVs designed to target diseases of the CNS.J Control Release2023
38074665Roles of extracellular vesicles in glioblastoma: foes, friends and informers.Front Oncol2023
37811539Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients.Neurooncol Adv2023
37408568Heparin interferes with the uptake of liposomes in glioma.Int J Pharm X2023
37198883Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers.Mol Ther2023
37194237Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles.Mol Ther2023
36811091Extracellular communication between brain cells through functional transfer of Cre mRNA.bioRxiv2023
36936071Illuminating cellular and extracellular vesicle-mediated communication via a split-Nanoluc reporter <i>in vitro</i> and <i>in vivo</i>.Cell Rep Methods2023
36427266Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma.Adv Mater2023
35033904Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo.Biomaterials2022
35846573Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.Mol Ther Methods Clin Dev2022
35572197CRISPR-Cas knockout of miR21 reduces glioma growth.Mol Ther Oncolytics2022
35417683Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo.Cell Rep2022
35590035Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins.Commun Biol2022
32975318TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism.Mov Disord2021
33548389Exosome-based liquid biopsies in cancer: opportunities and challenges.Ann Oncol2021
33523984Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin.Sci Adv2021
34298912Living Proof of Activity of Extracellular Vesicles in the Central Nervous System.Int J Mol Sci2021
34039790AAV9 transduction mediated by systemic delivery of vector via retro-orbital injection in newborn, neonatal and juvenile mice.Exp Anim2021
33234347Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes.Trends Neurosci2021
32457507RNA delivery by extracellular vesicles in mammalian cells and its applications.Nat Rev Mol Cell Biol2020
32019882Glioblastomas exploit truncated O<i>-</i>linked glycans for local and distant immune modulation via the macrophage galactose-type lectin.Proc Natl Acad Sci U S A2020
32075753Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.Cell Rep2020
31743443Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.J Comp Neurol2020
33282910Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression.Front Mol Biosci2020
32923886Exploring Predictors of Response to Dacomitinib in <i>EGFR</i>-Amplified Recurrent Glioblastoma.JCO Precis Oncol2020
32555306GlioM&amp;M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma.Sci Rep2020
32299465Glioblastoma hijacks microglial gene expression to support tumor growth.J Neuroinflammation2020
30561734Characterization of single microvesicles in plasma from glioblastoma patients.Neuro Oncol2019
31758005Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.Sci Rep2019
31839905Large and small extracellular vesicles released by glioma cells in vitro and in vivo.J Extracell Vesicles2019
31533034Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21.Cell Rep2019
31311653Glioma EVs Contribute to Immune Privilege in the Brain.Trends Cancer2019
31534984Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.Mol Ther Methods Clin Dev2019
30951671Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation.Cell2019
31092696Advances in therapeutic applications of extracellular vesicles.Sci Transl Med2019
30943406Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.Cell Rep2019
29016938Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.Neuro Oncol2018
30001512Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.Neuron2018
29858078CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.Mol Ther Nucleic Acids2018
30254196Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies.Nat Commun2018
29985475Multidimensional communication in the microenvirons of glioblastoma.Nat Rev Neurol2018
30571943Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.Neuron2018
30288631Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.Cell Mol Neurobiol2018
29474918Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly.Cell2018
29384376New Technologies for Analysis of Extracellular Vesicles.Chem Rev2018
29532035Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.Sci Adv2018
29396398Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.Sci Rep2018
29286635Multiplexed Profiling of Single Extracellular Vesicles.ACS Nano2018
29330365Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.Nat Commun2018
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Collaborators

Leonora Balaj
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Patricia L Kramer
Oregon Health & Science University
Co-authored papers 25
James F Gusella
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Christof M Kramm
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Co-authored papers 13
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Paul D Allen
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Evan Y Snyder
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
Arda Mizrak
University of California san francisco
Co-authored papers 4
William B Dobyns
University of Minnesota
Co-authored papers 4
Martin R Farlow
Stark Neurosciences Research Institute, Indiana University School of Medicine (IUSM)
Co-authored papers 3
Rudolph E Tanzi
Co-authored papers 3
Erdogan Pekcan Erkan
University of Helsinki
Co-authored papers 3
Neil W Kowall
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 3
Agnieszka Bronisz
Mossakowski Medical Research Institute, Polish Academy of Sciences
Co-authored papers 3
John C Hedreen
Co-authored papers 3
Rose-Mary Boustany
American University of Beirut Medical Center
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Martin Ingelsson
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Release 1.2