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Author Details

Iris Z Jaffe
Molecular Cardiology Research Institute, Tufts Medical Center
2005
91
39
PMIDPaper TitleJournal TitlePublished Year
37788489The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?Annu Rev Physiol2024
35020830Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing.Cardiovasc Res2023
36988926Association of Preexisting Heart Failure With Outcomes in Older Patients With Diffuse Large B-Cell Lymphoma.JAMA Cardiol2023
36815487Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.Circ Res2023
36440858Emerging vascular cell-specific roles for mineralocorticoid receptor: implications for understanding sex differences in cardiovascular disease.Am J Physiol Cell Physiol2023
36928870Using cultured canine cardiac slices to model the autophagic flux with doxorubicin.PLoS One2023
36337050Mechanism by Which Inflammation and Oxidative Stress Induce Mineralocorticoid Receptor Gene Expression in Aging Vascular Smooth Muscle Cells.Hypertension2023
34758633Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans.Arterioscler Thromb Vasc Biol2022
35510543Midgestation Leptin Infusion Induces Characteristics of Clinical Preeclampsia in Mice, Which Is Ablated by Endothelial Mineralocorticoid Receptor Deletion.Hypertension2022
35858116Histone Acetyltransferases in Smooth Muscle Cell Phenotype Switching: Redundant No Longer.Circulation2022
36213362ROCK and Rolling Towards Predicting BCR-ABL Kinase Inhibitor-Induced Vascular Toxicity.JACC CardioOncol2022
35179707VEGF Receptor Inhibitor-Induced Hypertension: Emerging Mechanisms and Clinical Implications.Curr Oncol Rep2022
33095647Sex differences in the time course and mechanisms of vascular and cardiac aging in mice: role of the smooth muscle cell mineralocorticoid receptor.Am J Physiol Heart Circ Physiol2021
33517669Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload-Induced Heart Failure.Circ Heart Fail2021
34615372Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.Arterioscler Thromb Vasc Biol2021
34018061Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in K<sub>v</sub> channels.Basic Res Cardiol2021
34324442MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms.JCI Insight2021
34211700Vascular cell-specific roles of mineralocorticoid receptors in pulmonary hypertension.Pulm Circ2021
33934622Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice.Hypertension2021
32324497Sex as a Biological Variable in Atherosclerosis.Circ Res2020
33228767Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice.Biol Sex Differ2020
32464187Sacubitril/Valsartan Improves Left Ventricular Function in Chronic Pressure Overload Independent of Intact Cyclic Guanosine Monophosphate-dependent Protein Kinase I Alpha Signaling.J Card Fail2020
30380007Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle.Am J Hypertens2019
31768474Comparative Transcriptomics of <i>Ex Vivo</i>, Patient-Derived Endothelial Cells Reveals Novel Pathways Associated With Type 2 Diabetes Mellitus.JACC Basic Transl Sci2019
31327274Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression.Hypertension2019
31294624Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner.Arterioscler Thromb Vasc Biol2019
31373631PKCδ Mediates Mineralocorticoid Receptor Activation by Angiotensin II to Modulate Smooth Muscle Cell Function.Endocrinology2019
31255553Univentricular Right Heart Support Using a Single Axial Flow Catheter for High Risk Multivessel Percutaneous Coronary Intervention.Cardiovasc Revasc Med2019
31507534Role of Aldosterone and Mineralocorticoid Receptor in Cardiovascular Aging.Front Endocrinol (Lausanne)2019
30767200Sex differences in mechanisms of arterial stiffness.Br J Pharmacol2019
30827147Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor.Hypertension2019
29237722Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.Circ Res2018
30049311Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction.J Am Coll Cardiol2018
30021779A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML.Blood Adv2018
30038907No Significant Role for Smooth Muscle Cell Mineralocorticoid Receptors in Atherosclerosis in the Apolipoprotein-E Knockout Mouse Model.Front Cardiovasc Med2018
29957022New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects.Am J Physiol Heart Circ Physiol2018
29604289Effect of Spironolactone on Myocardial Fibrosis and Other Clinical Variables in Patients with Hypertrophic Cardiomyopathy.Am J Med2018
29463624Smooth Muscle Cell-Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With Aging.Hypertension2018
29686001Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II.Hypertension2018
29798905Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone".Circ Res2018
29453308Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.J Am Heart Assoc2018
27888004Unliganded estrogen receptor alpha regulates vascular cell function and gene expression.Mol Cell Endocrinol2017
30062150Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model.JACC Basic Transl Sci2017
28089144Essential role of ICAM-1 in aldosterone-induced atherosclerosis.Int J Cardiol2017
28974571Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced Hypertension.Hypertension2017
28637706Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation.Physiol Rep2017
2863426730 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature.J Endocrinol2017
27930384The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease.Curr Opin Nephrol Hypertens2017
26879229Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.Circ Res2016
26422501Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration.Kidney Int2016
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Collaborators

Mary E Moss
Molecular Cardiology Research Institute (R.R.X., Tufts Medical Center
Co-authored papers 13
Qing Lu
Molecular Cardiology Research Institute, Tufts Medical Center
Co-authored papers 11
Michael E Mendelsohn
Co-authored papers 9
Richard H Karas
Co-authored papers 9
Subbian Ananth Karumanchi
Co-authored papers 7
Brigett V Carvajal
Molecular Cardiology Research Institute, Tufts Medical Center
Co-authored papers 4
Nicholas D Camarda
Molecular Cardiology Research Institute, Tufts Medical Center
Co-authored papers 3
Joshua A Beckman
University of Texas Southwestern Medical Center
Co-authored papers 3
Isaac E Stillman
Mount Sinai Hospital
Co-authored papers 3
Gordon H Williams
Co-authored papers 3
Peter M Kang
Beth Israel Deaconess Medical Center, Harvard Medical School
Co-authored papers 2
Ulla Hansen
Co-authored papers 2
James E Udelson
Tufts Medical Center
Co-authored papers 1
Desiree Davison
Co-authored papers 1
James Mullahoo
Co-authored papers 1
Malvina Papanastasiou
Co-authored papers 1
Paola Sebastiani
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center
Co-authored papers 1
Protiva Rahman
Vanderbilt University Medical Center
Co-authored papers 1
Kenneth B Miller
Tufts Medical Center
Co-authored papers 1
Megan M Shuey
Vanderbilt University Medical Center
Co-authored papers 1
Quinn S Wells
Vanderbilt University Medical Center
Co-authored papers 1
Rachel R Xiang
Molecular Cardiology Research Institute (R.R.X., Tufts Medical Center
Co-authored papers 1
Jadwiga Bienkowska
Pfizer Global Research and Development La Jolla
Co-authored papers 1
John B Wong
Tufts University School of Medicine
Co-authored papers 1
Yihua Wang
Molecular Cardiology Research Institute (R.R.X., Tufts Medical Center
Co-authored papers 1
Daniel Fabbri
Vanderbilt University Medical Center
Co-authored papers 1
Jacob Ramsey
Vanderbilt University Medical Center
Co-authored papers 1
Alec Stepanian
Molecular Cardiology Research Institute (R.R.X., Tufts Medical Center
Co-authored papers 1
Jacob D Jaffe
Co-authored papers 1
Release 1.2