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Author Details

Andrew Freywald
College of Medicine, University of Saskatchewan
1992
63
22
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36761420Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy.Front Oncol2023
37820398Survey of NF1 inactivation by surrogate immunohistochemistry in ovarian carcinomas.Gynecol Oncol2023
37392382Integration of cancer-related genetic landscape of Eph receptors and ephrins with proteomics identifies a crosstalk between EPHB6 and EGFR.Cell Rep2023
36976175A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.Clin Cancer Res2023
36587138A CRISPR Platform for Targeted In Vivo Screens.Methods Mol Biol2023
35184384Differential expression of HNF1A and HNF1A-AS1 in colon cancer cells.IUBMB Life2022
35883689A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers.Cells2022
33430292Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia.Cancers (Basel)2021
33770085Structure of the EphB6 receptor ectodomain.PLoS One2021
33828156Mining the plasma-proteome associated genes in patients with gastro-esophageal cancers for biomarker discovery.Sci Rep2021
34590285Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks.Methods Mol Biol2021
34782757Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors.Cell Mol Immunol2021
34233649Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.BMC Infect Dis2021
33066048The CINs of Polo-Like Kinase 1 in Cancer.Cancers (Basel)2020
30467420TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis.Cell Mol Immunol2019
31416843Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Databases.Cancer Res2019
30817936Targeting the CINful genome: Strategies to overcome tumor heterogeneity.Prog Biophys Mol Biol2019
30548174Molecular characterization of an MLL1 fusion and its role in chromosomal instability.Mol Oncol2019
30616753A Road Map to Personalizing Targeted Cancer Therapies Using Synthetic Lethality.Trends Cancer2019
29491429Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways.Sci Rep2018
30147642Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples.Front Neurosci2018
30374409Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability.NPJ Syst Biol Appl2018
29700392EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours.Oncogene2018
29415817Heterologous human/rat HER2-specific exosome-targeted T cell vaccine stimulates potent humoral and CTL responses leading to enhanced circumvention of HER2 tolerance in double transgenic HLA-A2/HER2 mice.Vaccine2018
27264687Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway.Cell Mol Immunol2017
28153727CD40 agonist converting CTL exhaustion via the activation of the mTORC1 pathway enhances PD-1 antagonist action in rescuing exhausted CTLs in chronic infection.Biochem Biophys Res Commun2017
28096300Enhanced suppression of polyclonal CD8<sup>+</sup>25<sup>+</sup> regulatory T cells via exosomal arming of antigen-specific peptide/MHC complexes.J Leukoc Biol2017
29196508An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.Mol Syst Biol2017
29116180The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment.Sci Rep2017
28670575CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy.Immunotargets Ther2017
26887372Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways.J Cell Biochem2016
27788485The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation.Oncotarget2016
27993084Novel T-cell-based vaccines via arming polyclonal CD4<sup>+</sup> T cells with antigen-specific exosomes.Immunotherapy2016
27557495Therapeutic relevance of the protein phosphatase 2A in cancer.Oncotarget2016
27418135Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment.Oncotarget2016
27158441IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia.Cell Biosci2016
25195511Transgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44(+)CD62L(high) IL-7R(+) CTLs with up- and downregulation of anti- and pro-apoptosis genes.Cell Mol Immunol2015
25963654Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining.Mol Cell Biol2015
25581780N-(2,4)-dinitrophenyl-L-arginine Interacts with EphB4 and Functions as an EphB4 Kinase Modulator.Chem Biol Drug Des2015
25546499Yeast mitochondrial protein-protein interactions reveal diverse complexes and disease-relevant functional relationships.J Proteome Res2015
25152370The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line.Cell Signal2014
25446836Building high-resolution synthetic lethal networks: a 'Google map' of the cancer cell.Trends Mol Med2014
25152371Ligand stimulation induces clathrin- and Rab5-dependent downregulation of the kinase-dead EphB6 receptor preceded by the disruption of EphB6-Hsp90 interaction.Cell Signal2014
23042534A novel T cell-based vaccine capable of stimulating long-term functional CTL memory against B16 melanoma via CD40L signaling.Cell Mol Immunol2013
23785406Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways.PLoS One2013
23113741Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency.Immunology2013
22424785CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene.Mol Immunol2012
23071696CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.PLoS One2012
21455264Dancing with the dead: Eph receptors and their kinase-null partners.Biochem Cell Biol2011
22039307EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.J Immunol2011
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Collaborators

Franco J Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 25
Frederick S Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 22
Tanya Freywald
University of Saskatchewan
Co-authored papers 12
Mohan Babu
University of Regina
Co-authored papers 4
Zhaolei Zhang
University of Toronto
Co-authored papers 3
Ramy H Malty
University of Toronto, University of Regina
Co-authored papers 2
Hiroyuki Aoki
University of Regina
Co-authored papers 2
Matthew Jessulat
University of Regina
Co-authored papers 2
Sadhna Phanse
University of Regina
Co-authored papers 2
Diem-Hang Nguyen-Tran
Institute of Applied Materials Science, Vietnam Academy of Science and Technology
Co-authored papers 2
Eytan Ruppin
National Cancer Institute
Co-authored papers 2
Viktor Deineko
University of Northern British Columbia
Co-authored papers 2
Ke Jin
West China Hospital, Sichuan University
Co-authored papers 2
Zoran Minic
University of Ottawa
Co-authored papers 2
James Vlasblom
University of Regina
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Ashkan Golshani
Ottawa Institute of Systems Biology, Carleton University
Co-authored papers 1
Bahram Samanfar
Agriculture and Agri-Food Canada
Co-authored papers 1
Glen B Baker
Neurochemical Research Unit, University of Alberta
Co-authored papers 1
Keren Yizhak
Co-authored papers 1
Fang-Xiang Wu
University of Saskatchewan
Co-authored papers 1
Mohsen Hooshyar
Department of Biology and Ottawa Institute of Systems Biology, Carleton University
Co-authored papers 1
Martin K??bel
University of Calgary
Co-authored papers 1
Daniel Burnside
Ottawa Institute of Systems Biology, University of Ottawa, Carleton University
Co-authored papers 1
Katayoun Omidi
Carleton University
Co-authored papers 1
Patrick Aloy
Institucio Catalana de Recerca i Estudis Avancats (ICREA)
Co-authored papers 1
Alana L Welm
Huntsman Cancer Institute, University of Utah
Co-authored papers 1
Bhanu Prasad Venkatesulu
Loyola University, Illinois Edward Hines Veteran Affairs Hospital
Co-authored papers 1
Michael Sela
Co-authored papers 1
Release 1.2