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Author Details

Marc M Loriaux
Knight Cancer Institute, Oregon Health & Science University
1991
78
39
PMIDPaper TitleJournal TitlePublished Year
35868306Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.Cancer Cell2022
34233449Aurora A kinase as a target for therapy in <i>TCF3-HLF</i> rearranged acute lymphoblastic leukemia.Haematologica2021
32513686Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia.Proc Natl Acad Sci U S A2020
32242922Mast cell sarcoma with concurrent mast cell leukaemia.Br J Haematol2020
30425048CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.Blood2019
30333627Functional genomic landscape of acute myeloid leukaemia.Nature2018
30018082Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.Sci Signal2018
29872489Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples.Oncotarget2018
28013106CPX-351 exhibits potent and direct ex vivo cytotoxicity against AML blasts with enhanced efficacy for cells harboring the FLT3-ITD mutation.Leuk Res2017
28385778Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma.Haematologica2017
28838991SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia.Haematologica2017
26095727Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance.Br J Haematol2016
26475333The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.Clin Cancer Res2016
27582059Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia.Sci Transl Med2016
25370416Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.Blood2015
26254279Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma.Oncotarget2015
26032424Therapeutically Targetable ALK Mutations in Leukemia.Cancer Res2015
26108689Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes.Leukemia2015
25895498YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.J Hematol Oncol2015
24659719A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor.Oncotarget2014
25293778BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Blood2014
23087056Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.Cancer Res2013
24286512Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine.Genome Med2013
24081659The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition.Blood2013
23900138CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway.Leukemia2013
23656643Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.N Engl J Med2013
23526721A case study of personalized therapy for osteosarcoma.Pediatr Blood Cancer2013
23544168Imatinib and Dasatinib Inhibit Hemangiosarcoma and Implicate PDGFR-β and Src in Tumor Growth.Transl Oncol2013
23220742The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.J Pharmacol Exp Ther2013
23303510HitWalker: variant prioritization for personalized functional cancer genomics.Bioinformatics2013
22038978In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia.Pediatr Blood Cancer2012
22960170An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma.Biochem Biophys Res Commun2012
23153538Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.Cancer Cell2012
22739646Creation of fibrinogen-enhanced experimental blood clots to evaluate mechanical thrombectomy devices for treatment of acute stroke: an in vitro study.J Vasc Interv Radiol2012
22889761Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML.Blood2012
22658276Multiplex high-throughput gene mutation analysis in acute myeloid leukemia.Hum Pathol2012
22345495TSLP signaling network revealed by SILAC-based phosphoproteomics.Mol Cell Proteomics2012
22425895Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.Leukemia2012
20959606CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.Blood2011
21860020TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.Blood2011
21552520Survey of activated FLT3 signaling in leukemia.PLoS One2011
21482694Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies.Mol Cancer Ther2011
21502425Association of JAK2 mutation status and cytogenetic abnormalities in myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms.Am J Clin Pathol2011
21157039Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity.J Clin Invest2011
19705199Thrombus formation after percutaneous catheterization and manual compression of the femoral artery in heparinized sheep.Cardiovasc Intervent Radiol2010
20670955MET receptor sequence variants R970C and T992I lack transforming capacity.Cancer Res2010
20112022Small intestinal submucosa plug for closure of dilated nephrostomy tracts: a pilot study in swine.Cardiovasc Intervent Radiol2010
20385788CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms.Blood2010
19837975A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib.Blood2010
18615102High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia.Leukemia2009
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Collaborators

Brian J Druker
Oregon Health & Science University
Co-authored papers 48
Jeffrey W Tyner
Oregon Health & Science University School of Medicine
Co-authored papers 40
Michael W Deininger
University of Utah Huntsman Cancer Institute
Co-authored papers 29
Christopher A Eide
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 16
Bill H Chang
Oregon Health and Science University
Co-authored papers 14
Anupriya Agarwal
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 12
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 12
Stephen E Spurgeon
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 12
Thomas O'Hare
Huntsman Cancer Institute, University of Utah
Co-authored papers 10
Beth Wilmot
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 9
Stephanie G Willis
OHSU Cancer Institute
Co-authored papers 8
Samuel B Luty
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 8
Daniel Bottomly
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 7
Guang Fan
Oregon Health and Science University
Co-authored papers 6
Julia E Maxson
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Russell T Burke
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 6
Melissa L Abel
National Cancer Institute, National Institutes of Health
Co-authored papers 5
Angela G Fleischman
University of California Irvine
Co-authored papers 5
Motomi Mori
St Jude Children's Research Hospital.
Co-authored papers 5
Cristina E Tognon
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 5
Elie Traer
Oregon Health & Science University
Co-authored papers 5
Nicola Long
Oregon Health and Science University
Co-authored papers 4
Jason Glover
Randall Children's Hospital
Co-authored papers 4
Jennifer Dunlap
Oregon Health & Science University
Co-authored papers 4
Dorian LaTocha
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 4
Christopher L Corless
Oregon Health & Science University
Co-authored papers 4
Jason Gotlib
Stanford University School of Medicine
Co-authored papers 4
David Tyler Sweeney
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Co-authored papers 4
Andy Kaempf
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Release 1.2