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Author Details

James R Heath
Institute of Systems Biology, University of Washington
1989
215
62
PMIDPaper TitleJournal TitlePublished Year
35547855Disease diagnostics using machine learning of immune receptors.bioRxiv2024
36356599Non-viral precision T cell receptor replacement for personalized cell therapy.Nature2023
37883974T cell receptor sequences are the dominant factor contributing to the phenotype of CD8<sup>+</sup> T cells with specificities against immunogenic viral antigens.Cell Rep2023
37193826Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.Commun Biol2023
37352211Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.PLoS One2023
37180102Prediction of HLA genotypes from single-cell transcriptome data.Front Immunol2023
37207206Effects of HLA single chain trimer design on peptide presentation and stability.Front Immunol2023
37202473Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions.Commun Chem2023
37001518Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities.Cell Syst2023
36890230Neoantigen-targeted CD8<sup>+</sup> T cell responses with PD-1 blockade therapy.Nature2023
34596849Protein Catalyzed Capture (PCC) Agents for Antigen Targeting.Methods Mol Biol2022
35576468The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.Proc Natl Acad Sci U S A2022
36817759Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping.Health Data Sci2022
36679852Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report.Vaccines (Basel)2022
36415462Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis.Res Sq2022
35875150Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer.Front Oncol2022
36066491Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.J Exp Med2022
35878026Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.Proc Natl Acad Sci U S A2022
35258337KIR<sup>+</sup>CD8<sup>+</sup> T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.Science2022
35043109The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.Res Sq2022
34489601Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19.Nat Biotechnol2022
33367885Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank.Neuro Oncol2021
33765435Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses.Immunity2021
33594379Characteristics and Factors Associated with COVID-19 Infection, Hospitalization, and Mortality Across Race and Ethnicity.medRxiv2021
34919800HLA-A<sup>⿿</sup>02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses.Cell Rep2021
34981055Human KIR <sup>+</sup> CD8 <sup>+</sup> T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19.bioRxiv2021
35237464Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease.J Alzheimers Dis Parkinsonism2021
34788328Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection.PLoS One2021
34683198Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study.Micromachines (Basel)2021
34188042Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1.Nat Commun2021
32393797Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line.Nat Commun2020
34122810Antibody-recruiting protein-catalyzed capture agents to combat antibiotic-resistant bacteria.Chem Sci2020
33171100Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.Cell2020
32973134Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells.Nat Commun2020
32995830Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.medRxiv2020
32766585Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories.bioRxiv2020
32793896A large-scale database of T-cell receptor beta (TCRβ) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2.Res Sq2020
32907318Visualizing Subcellular Enrichment of Glycogen in Live Cancer Cells by Stimulated Raman Scattering.Anal Chem2020
32371373Interdisciplinary Profile: An Established Chemist Journeys into Different Disciplines.iScience2020
30700902T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.Nat Methods2019
31502632MATE-Seq: microfluidic antigen-TCR engagement sequencing.Lab Chip2019
31559406Framing technology challenges associated with improving cancer immunotherapies.Lab Chip2019
316114134D electron microscopy of T cell activation.Proc Natl Acad Sci U S A2019
31495780Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.Cell Stem Cell2019
31347248Inhibition of heme sequestration of histidine-rich protein 2 using multiple epitope-targeted peptides.J Pept Sci2019
31484081Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood.Cell Rep2019
30838853Protein-Catalyzed Capture Agents.Chem Rev2019
31166947Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance.PLoS Comput Biol2019
30700903T cell antigen discovery via trogocytosis.Nat Methods2019
29319889Epitope-Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin-17F.Chemistry2018
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Collaborators

Yapeng Su
Fred Hutchinson Cancer Research Center, USA Clinical Research Division
Co-authored papers 28
Antoni Ribas
University of California Los Angeles (university of california los angeles)
Co-authored papers 16
Owen N Witte
University of California los angeles
Co-authored papers 10
Leroy Hood
Center for Phenomic Health, The Buck Institute for Research on Aging
Co-authored papers 10
Hsian-Rong Tseng
Jonsson Comprehensive Cancer Center, University of California los angeles
Co-authored papers 10
Rong Fan
Institute of Pathogens and Vectors, Dali University
Co-authored papers 9
Jennifer J Hadlock
Institute for Systems Biology
Co-authored papers 8
Mark M Davis
Co-authored papers 7
Paul S Mischel
Stanford University
Co-authored papers 7
Donghui Cheng
University of California los angeles
Co-authored papers 6
Steven W Millward
University of Texas MD Anderson Cancer Center
Co-authored papers 5
Timothy F Cloughesy
David Geffen School of Medicine, University of California Los Angeles
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Nathan D Price
Institute for Systems Biology
Co-authored papers 4
Ansuman T Satpathy
Stanford University
Co-authored papers 4
Jami McLaughlin
University of California los angeles
Co-authored papers 4
Andrew T Magis
Institute for Systems Biology
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Paul J Utz
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Bartosz Chmielowski
Jonsson Comprehensive Cancer Center, University of California Los Angeles
Co-authored papers 4
Naeha Subramanian
Institute for Systems Biology
Co-authored papers 4
Raphael Gottardo
Fred Hutchinson Cancer Center
Co-authored papers 3
Jocelyn T Kim
University of California Los Angeles
Co-authored papers 3
Arion F Chatziioannou
Crump Institute for Molecular Imaging, university of california los angeles
Co-authored papers 3
Scott D Boyd
Co-authored papers 3
Charles D James
Co-authored papers 3
Webster K Cavenee
Ludwig Institute for Cancer Research, University of California San Diego
Co-authored papers 3
Jesse M Zaretsky
University of California los angeles
Co-authored papers 3
Jared C Roach
Institute for Systems Biology
Co-authored papers 3
Yong-Hoon Kim
Kangwon National University School of Medicine
Co-authored papers 2
Steven A Rosenberg
University of Colorado School of Medicine
Co-authored papers 2
Alan Aderem
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Co-authored papers 2
Release 1.2