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Author Details

Jonathan B Cooper
University College London
1987
119
36
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37501200Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K.BMC Chem2023
34341193The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.Acta Crystallogr F Struct Biol Commun2021
34866602The X-ray structure of juvenile hormone diol kinase from the silkworm Bombyx mori.Acta Crystallogr F Struct Biol Commun2021
29652257Structure and function of the type III pullulan hydrolase from Thermococcus kodakarensis.Acta Crystallogr D Struct Biol2018
29908816Structural basis of pyrrole polymerization in human porphobilinogen deaminase.Biochim Biophys Acta Gen Subj2018
30198897Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.Acta Crystallogr D Struct Biol2018
28045381Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis.Acta Crystallogr D Struct Biol2017
28471366Structure of the family B DNA polymerase from the hyperthermophilic archaeon Pyrobaculum calidifontis.Acta Crystallogr D Struct Biol2017
29095161Structure and function of the thermostable L-asparaginase from Thermococcus kodakarensis.Acta Crystallogr D Struct Biol2017
29095155Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.Acta Crystallogr F Struct Biol Commun2017
27050260Binding of Gd(3+) to the neuronal signalling protein calexcitin identifies an exchangeable Ca(2+)-binding site.Acta Crystallogr F Struct Biol Commun2016
28255534The structure of Toho1 β-lactamase in complex with penicillin reveals the role of Tyr105 in substrate recognition.FEBS Open Bio2016
26630115Exploring the Mechanism of β-Lactam Ring Protonation in the Class A β-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography.J Med Chem2016
27795378Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam Substrate.Antimicrob Agents Chemother2016
27487824The 1.1⿿ÿ resolution structure of a periplasmic phosphate-binding protein from Stenotrophomonas maltophilia: a crystallization contaminant identified by molecular replacement using the entire Protein Data Bank.Acta Crystallogr D Struct Biol2016
27311939Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses.Angew Chem Int Ed Engl2016
25760610X-ray, spectroscopic and normal-mode dynamics of calexcitin: structure-function studies of a neuronal calcium-signalling protein.Acta Crystallogr D Biol Crystallogr2015
26542926Structure of a Kunitz-type potato cathepsin D inhibitor.J Struct Biol2015
26457516Extension of resolution and oligomerization-state studies of 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP.Acta Crystallogr F Struct Biol Commun2015
24419612The structure of endothiapepsin complexed with a Phe-Tyr reduced-bond inhibitor at 1.35 ÿ resolution.Acta Crystallogr F Struct Biol Commun2014
25485123Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein.IUCrJ2014
25195757Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP.Acta Crystallogr D Biol Crystallogr2014
25275273Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity.Biochem J2014
24915102Crystallization and preliminary X-ray characterization of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP.Acta Crystallogr F Struct Biol Commun2014
24598743Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution.Acta Crystallogr D Biol Crystallogr2014
23519422Insights into the mechanism of pyrrole polymerization catalysed by porphobilinogen deaminase: high-resolution X-ray studies of the Arabidopsis thaliana enzyme.Acta Crystallogr D Biol Crystallogr2013
23908040Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Bacillus megaterium.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
22525752An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.Acta Crystallogr D Biol Crystallogr2012
23192030Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana.Acta Crystallogr Sect F Struct Biol Cryst Commun2012
21168411The active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation.FEBS Lett2011
22102249Preliminary neutron crystallographic study of human transthyretin.Acta Crystallogr Sect F Struct Biol Cryst Commun2011
21128685A structural study of norovirus 3C protease specificity: binding of a designed active site-directed peptide inhibitor.Biochemistry2011
20036259Neutron diffraction studies of a class A beta-lactamase Toho-1 E166A/R274N/R276N triple mutant.J Mol Biol2010
21045318Crystallization and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael acceptor inhibitor.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20823511Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
19207107Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria.Biochem J2009
19616102Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.J Struct Biol2009
18479128The catalytic mechanism of an aspartic proteinase explored with neutron and X-ray diffraction.J Am Chem Soc2008
18765916Crystallization and preliminary X-ray diffraction analysis of L-threonine dehydrogenase (TDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.Acta Crystallogr Sect F Struct Biol Cryst Commun2008
18084100Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor.Acta Crystallogr Sect F Struct Biol Cryst Commun2007
16673078X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases.Eur Biophys J2006
16817889The molecular basis of heme oxygenase deficiency in the pcd1 mutant of pea.FEBS J2006
16950399High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomallei.J Mol Biol2006
16880550Crystallization and preliminary X-ray diffraction analysis of BipD, a virulence factor from Burkholderia pseudomallei.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
16414073The 1.6A X-ray structure of the unusual c-type cytochrome, cytochrome cL, from the methylotrophic bacterium Methylobacterium extorquens.J Mol Biol2006
16497326Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory.J Mol Biol2006
15663942The structure of the C-C bond hydrolase MhpC provides insights into its catalytic mechanism.J Mol Biol2005
16511184Crystallization and preliminary X-ray diffraction analysis of calexcitin from Loligo pealei: a neuronal protein implicated in learning and memory.Acta Crystallogr Sect F Struct Biol Cryst Commun2005
16131755Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid.Acta Crystallogr D Biol Crystallogr2005
16304458Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor.Acta Crystallogr D Biol Crystallogr2005
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Collaborators

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Co-authored papers 32
Center for Bioenergy, SASTRA Deemed University
Co-authored papers 7
University of California San Francisco
Co-authored papers 5
Synaptic Dynamics Inc.
Co-authored papers 5
The Howard Hughes Medical Institute, Salk Institute for Biological Studies
Co-authored papers 4
Lilly Research Laboratories
Co-authored papers 3
Pfizer Inc.
Co-authored papers 3
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Institute of Structural and Molecular Biology, University of London
Co-authored papers 1
University of Bristol
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
University of Toronto
Co-authored papers 1
Stanford University
Co-authored papers 1
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The Walter and Eliza Hall Institute of Medical Research
Co-authored papers 1
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Abo Akademi University
Co-authored papers 1