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Author Details

David Leppert
Biomedicine and Clinical Research, University Hospital Basel, University of Basel
1985
164
53
PMIDPaper TitleJournal TitlePublished Year
37285009Serum neurofilament light and white matter characteristics in the general population: a longitudinal analysis.Geroscience2024
37906326Ocrelizumab exposure in relapsing-remitting multiple sclerosis: 10-year analysis of the phase 2 randomized clinical trial and its extension.J Neurol2024
36708267A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients.J Magn Reson Imaging2023
37524100Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study.Lancet Neurol2023
37702323Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury.Clin Chem Lab Med2023
37354600Blood neurofilament light levels predict non-relapsing progression following anti-CD20 therapy in relapsing and primary progressive multiple sclerosis: findings from the ocrelizumab randomised, double-blind phase 3 clinical trials.EBioMedicine2023
37160117Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.Immunity2023
37076291Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis.J Neurol Neurosurg Psychiatry2023
36970523Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum.Front Neurol2023
37130728Association of serum neurofilament light with microglial activation in multiple sclerosis.J Neurol Neurosurg Psychiatry2023
37031551High serum neurofilament levels are observed close to disease activity events in pediatric-onset MS and MOG antibody-associated diseases.Mult Scler Relat Disord2023
36779855High serum neurofilament light chain levels correlate with brain atrophy and physical disability in multiple sclerosis.Eur J Neurol2023
36714921Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes.Biomarkers2023
36745446Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis.JAMA Neurol2023
36573731Demographic and disease-related factors impact on cerebrospinal fluid neurofilament light chain levels in multiple sclerosis.Brain Behav2023
34240656Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study.Mult Scler2022
35775045A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies.Front Neurol2022
35379762Blood Neurofilament Light in Progressive Multiple Sclerosis: Post Hoc Analysis of 2 Randomized Controlled Trials.Neurology2022
35575778Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis.JAMA Neurol2022
35495025Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation.Front Neurosci2022
35713309A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis.Ann Neurol2022
35848622Minocycline treatment in clinically isolated syndrome and serum NfL, GFAP, and metalloproteinase levels.Mult Scler2022
36582251Corrigendum: Determination of CSF GFAP, CCN5, and vWF levels enhances the diagnostic accuracy of clinically defined MS from non-MS patients with CSF oligoclonal bands.Front Immunol2022
36210459Metabolomics detects clinically silent neuroinflammatory lesions earlier than neurofilament-light chain in a focal multiple sclerosis animal model.J Neuroinflammation2022
35967378Distribution and efficacy of ofatumumab and ocrelizumab in humanized CD20 mice following subcutaneous or intravenous administration.Front Immunol2022
35902720The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis.Sci Rep2022
36192181Author Response: Blood Neurofilament Light in Progressive Multiple Sclerosis: Post Hoc Analysis of 2 Randomized Controlled Trials.Neurology2022
36151266Longitudinal analyses of serum neurofilament light and associations with obesity indices and bioelectrical impedance parameters.Sci Rep2022
35288475Reader Response: Serum Neurofilament Light Association With Progression in Natalizumab-Treated Patients With Relapsing-Remitting Multiple Sclerosis.Neurology2022
35185866Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands.Front Immunol2022
35035990Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS.Mult Scler J Exp Transl Clin2022
35299779Neuro-axonal injury in COVID-19: the role of systemic inflammation and SARS-CoV-2 specific immune response.Ther Adv Neurol Disord2022
35229997Development of an age-adjusted model for blood neurofilament light chain.Ann Clin Transl Neurol2022
35293622Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.Ann Neurol2022
34378446Sustained reduction of serum neurofilament light chain over 7â¿¿years by alemtuzumab in early relapsing-remitting MS.Mult Scler2022
33098034Serum neurofilament light chain as outcome marker for intensive care unit patients.J Neurol2021
33769117Disability improvement as a clinically relevant outcome in clinical trials of relapsing forms of multiple sclerosis.Mult Scler2021
33653962Anti-CD20 Disrupts Meningeal B-Cell Aggregates in a Model of Secondary Progressive Multiple Sclerosis.Neurol Neuroimmunol Neuroinflamm2021
33566157Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants.J Neurol2021
33871105Neurofilament light chain as a marker for cortical atrophy in multiple sclerosis without radiological signs of disease activity.J Intern Med2021
33583409Serum neurofilament light and tau as prognostic markers for all-cause mortality in the elderly general population-an analysis from the MEMO study.BMC Med2021
33556656Increased serum glial fibrillary acidic protein associates with microstructural white matter damage in multiple sclerosis: GFAP and DTI.Mult Scler Relat Disord2021
34923481Factors influencing serum neurofilament light chain levels in normal aging.Aging (Albany NY)2021
34612753Measurement of neurofilaments improves stratification of future disease activity in early multiple sclerosis.Mult Scler2021
34755110Objective biomarkers for clinical relapse in multiple sclerosis: a metabolomics approach.Brain Commun2021
34352610Serum neurofilament is associated with motor function, cognitive decline and subclinical cardiac damage in advanced Parkinson's disease (MARK-PD).Parkinsonism Relat Disord2021
34043255Reply to: Neurofilament Light Chain in Patients with COVID-19 and Bacterial Pneumonia.Ann Neurol2021
33933106Serum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.J Neuroinflammation2021
34057235Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis.Ann Neurol2021
34088875Chronic White Matter Inflammation and Serum Neurofilament Levels in Multiple Sclerosis.Neurology2021
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Collaborators

Stephen L Hauser
Co-authored papers 12
Emmanuelle Waubant
University of California san francisco
Co-authored papers 7
Klaus Berger
Co-authored papers 7
Fredrik Piehl
Co-authored papers 7
Karl Frei
University Hospital Zurich
Co-authored papers 5
Xavier Montalban
Co-authored papers 4
Paul M Matthews
UK Dementia Research Institute Centre at Imperial College London
Co-authored papers 4
Rachel A Gibson
Guy's Hospital
Co-authored papers 4
Axel Petzold
Moorfields Eye Hospital
Co-authored papers 4
Lefkos T Middleton
Ageing Epidemiology Research Unit, School of Public Health, Imperial College London
Co-authored papers 4
Giancarlo Comi
Co-authored papers 4
Bruce A C Cree
Co-authored papers 4
Howard L Weiner
Co-authored papers 4
Murali Ramanathan
Department of Pharmaceutical Sciences, State University of New York
Co-authored papers 3
Tomas Olsson
Co-authored papers 3
Heinz Gregor Wieser
University of ZurichZurichSwitzerland.
Co-authored papers 3
Manuel Comabella
Co-authored papers 3
Ingrid Kockum
Co-authored papers 3
Jorge R Oksenberg
Co-authored papers 3
Raoul Sutter
University Hospital Basel
Co-authored papers 3
Chantal Depondt
Hopital Universitaire de Bruxelles - Hopital Erasme
Co-authored papers 2
Michael Kabesch
Co-authored papers 2
Colin P Doherty
St James's Hospital
Co-authored papers 2
G??nter Kr??mer
University Hospital
Co-authored papers 2
Kevin V Shianna
Illumina Inc. 5200 Illumina Way
Co-authored papers 2
Anne H Cross
Co-authored papers 2
John S Duncan
UCL Queen Square Institute of Neurology, University College London
Co-authored papers 2
Claudia B Catarino
Friedrich-Baur-Institut, Ludwig-Maximilians-Universitat Munchen
Co-authored papers 2
David B Goldstein
Institute for Genomic Medicine, Columbia University Irving Medical Center
Co-authored papers 2
Dominik Zumsteg
University of Toronto, Toronto Western Hospital
Co-authored papers 2
Release 1.2