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Author Details

David Neuhaus
Medical Research Council - Laboratory of Molecular Biology
1984
79
39
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37061529Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.Nat Commun2023
37326024Updated protein domain annotation of the PARP protein family sheds new light on biological function.Nucleic Acids Res2023
34499853Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.Structure2022
36113918Zinc finger structure determination by NMR: Why zinc fingers can be a handful.Prog Nucl Magn Reson Spectrosc2022
33619271RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.Nat Commun2021
33511412Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.Nucleic Acids Res2021
32155440Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.Dev Cell2020
32028527HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.Nature2020
33024112Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.Nat Commun2020
31582740A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.Nat Commun2019
29667579Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.Elife2018
28879231Homeodomain-like DNA binding proteins control the haploid-to-diploid transition in <i>Dictyostelium</i>.Sci Adv2017
27247287Fifty years of "Progress in NMR Spectroscopy" - An editorial from the present Editorial Board.Prog Nucl Magn Reson Spectrosc2016
25703931¹¹³Cd⿿NMR experiments reveal an unusual metal cluster in the solution structure of the yeast splicing protein Bud31p.Angew Chem Int Ed Engl2015
26626479Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.Mol Cell2015
27478262<sup>113</sup>Cdâ¿¿NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.Angew Chem Weinheim Bergstr Ger2015
23871147DNA-dependent SUMO modification of PARP-1.DNA Repair (Amst)2013
22560733Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export.Structure2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
21262234The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.J Mol Biol2011
21666677Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.Nat Struct Mol Biol2011
21240272Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.Nat Struct Mol Biol2011
20098424Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).Nat Struct Mol Biol2010
19401465Structural requirements for the ubiquitin-associated domain of the mRNA export factor Mex67 to bind its specific targets, the transcription elongation THO complex component Hpr1 and nucleoporin FXFG repeats.J Biol Chem2009
18190927Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2.J Mol Biol2008
18621724Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif.Proc Natl Acad Sci U S A2008
17475778Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA export factor Mex67.Mol Biol Cell2007
17609377Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.Proc Natl Acad Sci U S A2007
17355883How the N-terminal domain of the OSCP subunit of bovine F1Fo-ATP synthase interacts with the N-terminal region of an alpha subunit.J Mol Biol2007
16545913Identification of new differentiation inducing factors from Dictyostelium discoideum.Biochim Biophys Acta2006
15990112Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase.J Mol Biol2005
15837933Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.Proc Natl Acad Sci U S A2005
16045926Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit.J Mol Biol2005
15101973Solution structure and domain architecture of the divisome protein FtsN.Mol Microbiol2004
15288782Solution structure and DNA binding of the zinc-finger domain from DNA ligase IIIalpha.J Mol Biol2004
15312772The structure and biochemical properties of the human spliceosomal protein U1C.J Mol Biol2004
15456745Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.J Biol Chem2004
15327958Solution structure of subunit F(6) from the peripheral stalk region of ATP synthase from bovine heart mitochondria.J Mol Biol2004
12581645Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution.J Mol Biol2003
14556747Solution NMR study of the interaction between NTF2 and nucleoporin FxFG repeats.J Mol Biol2003
11875519Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1.Nat Struct Biol2002
11162601Solution studies of chymotrypsin inhibitor-2 glutamine insertion mutants show no interglutamine interactions.Biochem Biophys Res Commun2001
11344319HMG-D complexed to a bulge DNA: an NMR model.Protein Sci2001
11327770Solution structure of a C-terminal coiled-coil domain from bovine IF(1): the inhibitor protein of F(1) ATPase.J Mol Biol2001
10742179The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.Nat Struct Biol2000
11080160The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p.EMBO J2000
9566313Determination of the NMR structure of the complex between U1A protein and its RNA polyadenylation inhibition element.J Biomol NMR1998
9878374Solution structure of the motile major sperm protein (MSP) of Ascaris suum - evidence for two manganese binding sites and the possible role of divalent cations in filament formation.J Mol Biol1998
9664658Amoeboid motility without actin: insights into the molecular mechanism of locomotion using the major sperm protein (MSP) of nematodes.Biol Bull1998
9312034Structural basis of the RNA-binding specificity of human U1A protein.EMBO J1997
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Collaborators

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Oncology R&D
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University of Toronto
Co-authored papers 2
Institute of Human Genetics, UMR 9002 CNRS - University of Montpellier
Co-authored papers 2
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Co-authored papers 1
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Co-authored papers 1
University of Illinois
Co-authored papers 1
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Technische Universitat Munchen (TUM)
Co-authored papers 1
University of Bristol
Co-authored papers 1
The University of Manchester
Co-authored papers 1
Rutgers University
Co-authored papers 1
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
The University of Sheffield
Co-authored papers 1
Institute of Systems, The University of Liverpool
Co-authored papers 1
University of Oxford
Co-authored papers 1
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
Columbia University
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National Institutes of Health
Co-authored papers 1
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
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University of Oxford
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The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
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University of Cambridge
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Carnegie Mellon University
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Imperial College London
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Institute for Protein Research, Osaka University
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