Author details

Full Name

Ettore Appella

Affiliation

ORCID

Career Start Year

1960

Papers

564

H Index

129

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37024617	Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques.	Nat Microbiol	2023
37217721	Publisher Correction: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques.	Nat Microbiol	2023
36713582	Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile.	Front Oncol	2023
35124007	InÂ vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-Î³1 in T cells.	J Biol Chem	2022
36179402	Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase.	European Journal of Medicinal Chemistry	2022
36268125	Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.	ACS Pharmacol Transl Sci	2022
34131120	Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses.	Nature Communications	2021
32393514	An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes.	J Immunol	2020
32312843	The p53 Saga: Early Steps in the Development of Tumor Immunotherapy.	Journal of Immunology	2020
31481464	Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.	J Biol Chem	2019
30587568	Pillars Article: Purification of a Human Monocyte-Derived Neutrophil Chemotactic Factor That Has Peptide Sequence Similarity to Other Host Defense Cytokines. <i>Proc. Natl. Acad. Sci. USA</i> 1987. 84: 9233-9237.	J Immunol	2019
29602904	A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.	Journal of Biological Chemistry	2018
30510001	Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation.	Proceedings of the National Academy of Sciences of the United States of America	2018
29357353	Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.	PLoS Biol	2018
29440413	Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70<sup>T293</sup> and destabilization of the signalosome.	Proc Natl Acad Sci U S A	2018
29476592	Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain.	ChemMedChem	2018
29472616	Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.	Nat Commun	2018
28073004	Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.	Cancer Cell	2017
28588284	A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins.	Emerg Microbes Infect	2017
28481111	Conformational Changes in Active and Inactive States of Human PP2CÎ± Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.	Biochemistry	2017
27074569	Targeting cancer stem cells with p53 modulators.	Oncotarget	2016
26063730	Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells.	Molecular Biology of the Cell	2015
25753752	Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex.	Biochemistry	2015
25579814	Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.	Structure	2015
25651062	An acetyl-methyl switch drives a conformational change in p53.	Structure	2015
26354433	Introduction to thematic series: protein interactions, structures, and networks.	J Biol Chem	2015
24552809	Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.	Cell Cycle	2014
25476896	Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells.	Cell Death and Disease	2014
25516717	SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.	Int J Biol Sci	2014
23770853	The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.	Oncogene	2014
25144556	Autophagic degradation of the inhibitory p53 isoform Î¿133p53Î± as a regulatory mechanism for p53-mediated senescence.	Nat Commun	2014
24130806	Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells.	PLoS ONE	2013
23907125	Genetic variants and mutations of PPM1D control the response to DNA damage.	Cell Cycle	2013
23906386	Binding of a third metal ion by the human phosphatases PP2CÎ± and Wip1 is required for phosphatase activity.	Biochemistry	2013
23979596	Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.	Molecular and Cellular Biology	2013
24231352	p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.	Journal of Clinical Investigation	2013
22201816	Regulation of the Wip1 phosphatase and its effects on the stress response.	Frontiers in Bioscience - Landmark	2012
22306578	Polyproline and Tat transduction peptides in the study of the rapid actions of steroid receptors.	Steroids	2012
22505655	p53 N-terminal phosphorylation: a defining layer of complex regulation.	Carcinogenesis	2012
22544321	Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.	Cell Cycle	2012
22640875	Radioprobing the conformation of DNA in a p53-DNA complex.		2012
22065775	Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.	Proceedings of the National Academy of Sciences of the United States of America	2012
21593172	One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.	J Virol	2011
20947453	UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.		2011
21452853	Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites.	Biochemistry	2011
21528848	Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).	Biochemistry	2011
21883927	Special issue: Protein structure and proteomics: introduction.		2011
21750420	Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.	AIDS	2011
20307547	Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.	J Mol Biol	2010
19562340	Identification of a 17beta-hydroxysteroid dehydrogenase type 12 pseudogene as the source of a highly restricted BALB/c Meth A tumor rejection peptide.	Cancer Immunol Immunother	2010