Author details

Full Name

Anton Simeonov

Affiliation

ORCID

Career Start Year

1996

Papers

318

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37506331	High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions.	Annu Rev Pharmacol Toxicol	2024
36719788	Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates.		2023
36261632	Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail.	Nat Protoc	2023
37677128	Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds.		2023
37737090	Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.		2023
37558718	Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.	Nat Commun	2023
37683456	Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.	Biochem Biophys Res Commun	2023
36910140	Editorial: Biophysical target engagement assays in chemical biology and pharmacological research.		2023
36709665	Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury.		2023
37200814	Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.		2023
37327313	Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.	Proc Natl Acad Sci U S A	2023
36634189	Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development.		2023
37321325	In vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity.		2023
36562206	Advances in luminescence-based technologies for drug discovery.		2023
37169224	Small molecule antiviral compound collection (SMACC): A comprehensive, highly curated database to support the discovery of broad-spectrum antiviral drug molecules.		2023
37044067	Scalable generation of sensory neurons from human pluripotent stem cells.	Stem Cell Reports	2023
36926457	Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs.	ACS Pharmacol Transl Sci	2023
36856421	Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc.		2023
37292747	Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors.		2023
35141848	Correction to: Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules.	Methods Mol Biol	2022
36049119	Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement.	ACS Chem Biol	2022
36229506	Author Correction: A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.	Sci Rep	2022
35648838	Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19.	ACS Infect Dis	2022
36029455	Correction to: LUHMES Dopaminergic Neurons are Uniquely Susceptible to Ferroptosis.	Neurotoxicity Research	2022
35505094	Correction to: Thymine DNA glycosylase as a novel target for melanoma.	Oncogene	2022
36289220	Revealing Î²-TrCP activity dynamics in liveÂ cells with a genetically encoded biosensor.	Nature Communications	2022
35821746	Allosteric Binders of ACE2 Are Promising Anti-SARS-CoV-2 Agents.	ACS Pharmacology and Translational Science	2022
35696646	Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.	J Med Chem	2022
35435491	Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation.	Arch Toxicol	2022
36150479	Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data.	Toxicology and Applied Pharmacology	2022
36074125	Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.	Journal of Medicinal Chemistry	2022
36074076	A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase.	Molecular Biology of the Cell	2022
36334045	Application of biophysical methods for improved protein production and characterization: A case study on an high-temperature requirement A-family bacterial protease.	Protein Science	2022
36134655	Multidimensional analysis and therapeutic development using patient iPSC-derived disease models of Wolfram syndrome.	JCI insight	2022
35416705	Controlled Proteolysis of an Essential Virulence Determinant Dictates Infectivity of Lyme Disease Pathogens.	Infection and Immunity	2022
35922689	LUHMES Dopaminergic Neurons Are Uniquely Susceptible to Ferroptosis.	Neurotoxicity Research	2022
35860225	Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules.		2022
35787375	A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2.	Journal of Biological Chemistry	2022
36506591	Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries.		2022
36669818	Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122].	Genomics Proteomics Bioinformatics	2022
34128205	Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules.	Methods Mol Biol	2022
35313579	Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents.		2022
35258332	A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System.	mBio	2022
35041689	A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.	PLoS One	2022
34729560	A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.	bioRxiv	2022
35169799	A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19.	bioRxiv	2022
34527302	A systems approach to enable effective team science from the internal research program of the National Center for Advancing Translational Sciences.	J Clin Transl Sci	2021
34242083	Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite.	Environ Health Perspect	2021
33910017	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.	Cell Reports	2021
33483532	Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.	Sci Rep	2021