Author details

Full Name

Harold Varmus

Affiliation

ORCID

Career Start Year

1969

Papers

436

H Index

132

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36715544	LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.		2023
37694893	Threatening the Global AIDS Response - Obstacles to PEPFAR's Reauthorization.		2023
35139387	Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells.	Cell Rep	2022
34895873	New York's Polyethnic-1000: a regional initiative to understand how diverse ancestries influence the risk, progression, and treatment of cancers.	Trends Cancer	2022
34848863	The United States needs a department of technology and science policy.	Nature	2021
33833113	Concrete steps to diversify the scientific workforce.	Science	2021
34793208	Create a COVID-19 commission.	Science	2021
30737256	Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.	J Exp Med	2019
30824525	Of oncogenes and open science: an interview with Harold Varmus.	DMM Disease Models and Mechanisms	2019
29773737	Improving support for young biomedical scientists.	Science	2018
29875142	<i>YES1</i> amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.	Proc Natl Acad Sci U S A	2018
30475204	Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells.	eLife	2018
30322915	Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene <i>U2af1</i>.	Proc Natl Acad Sci U S A	2018
29191895	Insurance for broad genomic tests in oncology.	Science	2017
28985568	A Prize for Cancer Prevention.	Cell	2017
28888324	A Prize for Cancer Prevention.	Cell	2017
27776121	Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.	PLoS Genet	2016
27124426	The transformation of oncology.	Science	2016
27702896	Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.	Proc Natl Acad Sci U S A	2016
27653561	Toward a Shared Vision for Cancer Genomic Data.	N Engl J Med	2016
28123049	How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?	Cold Spring Harbor Symposia on Quantitative Biology	2016
26151250	Varmus Returns to His Roots in Cancer Genetics.	JAMA - Journal of the American Medical Association	2015
25635347	A new initiative on precision medicine.	N Engl J Med	2015
25596284	ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.	Cancer Res	2015
25452448	National Cancer Institute-supported clinical trials networks.	J Clin Oncol	2015
25735773	Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.	Cancer Discov	2015
25691698	Opinion: Addressing systemic problems in the biomedical research enterprise.	Proceedings of the National Academy of Sciences of the United States of America	2015
26047463	Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.	Elife	2015
24733905	Rescuing US biomedical research from its systemic flaws.	Proceedings of the National Academy of Sciences of the United States of America	2014
24535670	Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.	Cancer Discov	2014
23467558	Addressing the growing international challenge of cancer: a multinational perspective.	Science Translational Medicine	2013
24255704	DOK2 inhibits EGFR-mutated lung adenocarcinoma.	PLoS One	2013
22233804	Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.	Proc Natl Acad Sci U S A	2012
22617420	Three decades of Wnts: a personal perspective on how a scientific field developed.	EMBO Journal	2012
22570861	A conversation with Harold Varmus. Interview by Ushma S. Neill.	Journal of Clinical Investigation	2012
22281578	Science funding: Provocative questions in cancer research.	Nature	2012
23129625	Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.	Proceedings of the National Academy of Sciences of the United States of America	2012
21734681	NIH cancer chief wants more with less: by Meredith Wadman.	Nature	2011
21930909	Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.	Proc Natl Acad Sci U S A	2011
22049067	Epstein-Barr virus: an important vaccine target for cancer prevention.	Science Translational Medicine	2011
21907921	Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.	Cancer Cell	2011
21940500	Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis.	Proceedings of the National Academy of Sciences of the United States of America	2011
21937755	Integrating cancer control into global health.	Science Translational Medicine	2011
21778374	Newsmaker interview: Harold Varmus. Piloting cancer research with a shrinking budget. Interview by Jocelyn Kaiser.	Science	2011
20505183	Ten years on--the human genome and medicine.	New England Journal of Medicine	2010
20007486	Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma.	DMM Disease Models and Mechanisms	2010
20601955	Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.	Nat Genet	2010
19812721	Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.	PLoS ONE	2009
19137012	MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.	Oncogene	2009
19299588	The enlightenment returns.	Science	2009