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Author Details

Shinichi Someya
University of Florida
1985
46
25
PMIDPaper TitleJournal TitlePublished Year
35997776Disease correction in mucopolysaccharidosis type IIIB mice by intraparenchymal or cisternal delivery of a capsid modified AAV8 codon-optimized NAGLU vector.Hum Mol Genet2023
36577362Taurine, Coenzyme Q<sub>10</sub>, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.Hear Res2023
36599258Sex differences in body composition, voluntary wheel running activity, balance performance, and auditory function in CBA/CaJ mice across the lifespan.Hear Res2023
36493529The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging.Hear Res2023
32600853Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.Hear Res2021
33900547Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage.Neurotox Res2021
31622631"Passenger gene" problem in transgenic C57BL/6 mice used in hearing research.Neurosci Res2020
32044382Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.Exp Gerontol2020
33191210Innovations in Geroscience to enhance mobility in older adults.Exp Gerontol2020
32866605Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan.Exp Gerontol2020
31344454Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.Exp Gerontol2019
31824252A Novel Mouse Model of <i>MYO7A</i> USH1B Reveals Auditory and Visual System Haploinsufficiencies.Front Neurosci2019
31515474GSTA4 mediates reduction of cisplatin ototoxicity in female mice.Nat Commun2019
29567975Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice.Sci Rep2018
28818524Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.Neuroscience2017
31305776Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.Nat Commun2017
28158260Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.PLoS One2017
28473643<i>G6pd</i> Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea.J Neurosci2017
28205519Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.Nat Commun2017
28852116Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics.Sci Rep2017
28686716GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR.PLoS One2017
27255815Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.Neurobiol Aging2016
27582696GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus.Front Behav Neurosci2016
27784315Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.J Transl Med2016
27807171Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.J Neurosci2016
25978367Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.PLoS One2015
26462882Successful aging: Advancing the science of physical independence in older adults.Ageing Res Rev2015
25830335A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.PLoS One2015
22820179Mouse models of age-related mitochondrial neurosensory hearing loss.Mol Cell Neurosci2013
25419212Ototoxic Model of Oxaliplatin and Protection from Nicotinamide Adenine Dinucleotide.J Otol2013
24223197Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures.PLoS One2013
23422312Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.Hear Res2013
23454634Maintaining good hearing: calorie restriction, Sirt3, and glutathione.Exp Gerontol2013
21942371Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.Antioxid Redox Signal2012
25593588OTOTOXIC EFFECTS OF CARBOPLATIN IN ORGANOTYPIC CULTURES IN CHINCHILLAS AND RATS.J Otol2012
20434479Mitochondrial oxidative damage and apoptosis in age-related hearing loss.Mech Ageing Dev2010
21094524Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.Cell2010
20628647Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.PLoS One2010
20298166Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys.Curr Aging Sci2010
19901338Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.Proc Natl Acad Sci U S A2009
17363114The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.Neurobiol Aging2008
16890326Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis.Neurobiol Aging2007
17964557Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice.Brain Res2007
16870370Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.Hear Res2007
16020738Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.Science2005
4010930Depolarizing afterpotentials in myelinated axons of mammalian spinal cord.Neuroscience1985
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Collaborators

The University of Tokyo
Co-authored papers 10
Institute on Aging, University of Florida
Co-authored papers 8
University of Florida
Co-authored papers 5
University of Florida College of Medicine
Co-authored papers 3
University of Florida College of Medicine
Co-authored papers 3
University of Florida
Co-authored papers 3
University of Florida
Co-authored papers 2
College of Liberal Arts and Sciences, University of Florida
Co-authored papers 2
University of Florida, McKnight Brain Institute
Co-authored papers 2
University of Florida
Co-authored papers 2
Institute on Aging, University of Florida
Co-authored papers 2
University of Florida, Washington State University
Co-authored papers 2
College of Medicine
Co-authored papers 2
University of Florida
Co-authored papers 2
University of Florida
Co-authored papers 2
University of Florida
Co-authored papers 2
McKnight Brain Institute, University of Florida
Co-authored papers 2
University of Florida
Co-authored papers 2
Johns Hopkins Bloomberg School of Public Health
Co-authored papers 1
University of Florida
Co-authored papers 1
University of Florida
Co-authored papers 1
University of Florida
Co-authored papers 1
College of Public Health and Health Professions, University of Florida
Co-authored papers 1
University of Florida
Co-authored papers 1
Geriatric Research and Education Clinical Center (GRECC)
Co-authored papers 1
University of Florida
Co-authored papers 1
College of Medicine, University of Florida
Co-authored papers 1
University of Florida
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Institute on Aging, University of Florida
Co-authored papers 1
Bensadon Medical Psychology and Geriatrics PLLC
Co-authored papers 1