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Author Details

Kylie J Walters
Center for Cancer Research, National Cancer Institute, National Institutes of Health
1993
85
35
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36827983E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.Structure2023
37590133A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.Cell Rep2023
37645848<sup>1</sup>H, <sup>15</sup>N, <sup>13</sup>C resonance assignments for proteasome shuttle factor hHR23a.Res Sq2023
37812322<sup>1</sup>H, <sup>15</sup>N, <sup>13</sup>C resonance assignments for proteasome shuttle factor hHR23a.Biomol NMR Assign2023
37354974An engineered cell line with a hRpn1-attached handle to isolate proteasomes.J Biol Chem2023
37022617<sup>1</sup>H, <sup>15</sup>N, <sup>13</sup>C backbone and Cβ resonance assignments for UBQLN1 UBA and UBAA domains.Biomol NMR Assign2023
37438348Structural and photophysical characterization of the small ultra-red fluorescent protein.Nat Commun2023
36747801A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.bioRxiv2023
34995507Nuclear destruction: A suicide mission by AKIRIN2 brings intact proteasomes into the nucleus.Mol Cell2022
35617919The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization.J Magn Reson2022
35817651Proteasome substrate receptors and their therapeutic potential.Trends Biochem Sci2022
35452608Quality Control: Maintaining molecular order and preventing cellular chaos.Mol Cell2022
35046575Can AlphaFold2 predict the impact of missense mutations on structure?Nat Struct Mol Biol2022
35000205Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.Ann N Y Acad Sci2022
33211406Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies.FEBS J2021
33521680An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub<sub>6</sub>.STAR Protoc2021
33483207Editorial overview: Macromolecular assemblies: clues from structural insights.Curr Opin Struct Biol2021
34916494Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.Nat Commun2021
34862367Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein.Nat Commun2021
32157086Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10.Nat Commun2020
33101674Metabolic plasticity of IDH1<i>-mutant</i> glioma cell lines is responsible for low sensitivity to glutaminase inhibition.Cancer Metab2020
32631902Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.Mol Cell Biol2020
32783951Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome.Structure2020
32160516An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.Structure2020
30664872Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.J Mol Biol2019
31672988Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.Nat Commun2019
31371495Ubiquitin in disguise unveils a cryptic binding site in 1.2-MDa anaphase-promoting complex/cyclosome.Proc Natl Acad Sci U S A2019
30288466Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer.ACS Omega2018
30315240Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex.Nat Commun2018
28598414Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.Nat Commun2017
26971995Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.Cell Rep2016
26650755Mycobacterium tuberculosis copper-regulated protein SocB is an intrinsically disordered protein that folds upon interaction with a synthetic phospholipid bilayer.Proteins2016
26643069Gates, Channels, and Switches: Elements of the Proteasome Machine.Trends Biochem Sci2016
27396824Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.Structure2016
27114451Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.Mol Cell Proteomics2016
27188292(1)H, (15)N, (13)C resonance assignments for Saccharomyces cerevisiae Rad23 UBL domain.Biomol NMR Assign2016
27543075Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.Nucleic Acids Res2016
26912900Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.Science2016
26907685The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression.J Biol Chem2016
26950368Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.Nat Struct Mol Biol2016
25747657Structural plasticity allows UCH37 to be primed by RPN13 or locked down by INO80G.Mol Cell2015
26466095A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells.PLoS One2015
26168740Artificial targeting of misfolded cytosolic proteins to endoplasmic reticulum as a mechanism for clearance.Sci Rep2015
23562395Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 binding.Structure2013
24332045A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer.Cancer Cell2013
23672618Structural insights into proteasome activation by the 19S regulatory particle.Biochemistry2013
22350893Identifying and studying ubiquitin receptors by NMR.Methods Mol Biol2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
23153250MTMDAT-HADDOCK: high-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry.BMC Struct Biol2012
22652769Ubiquitin and its binding domains.Front Biosci (Landmark Ed)2012
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Collaborators

Frederick National Laboratory for Cancer Research
Co-authored papers 6
The National Institutes of Health
Co-authored papers 5
Institute of Biochemistry II, Goethe University Frankfurt
Co-authored papers 4
Bijvoet Center for Biomolecular Research, Utrecht University
Co-authored papers 2
University of California San Francisco
Co-authored papers 1
University of Illinois
Co-authored papers 1
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Technische Universitat Munchen (TUM)
Co-authored papers 1
University of Bristol
Co-authored papers 1
The University of Manchester
Co-authored papers 1
Rutgers University
Co-authored papers 1
King's College London
Co-authored papers 1
National Cancer Institute, National Institutes of Health
Co-authored papers 1
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
The University of Sheffield
Co-authored papers 1
Institute of Systems, The University of Liverpool
Co-authored papers 1
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
Columbia University
Co-authored papers 1
University of California Irvine
Co-authored papers 1
National Institutes of Health
Co-authored papers 1
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
Co-authored papers 1
University of Oxford
Co-authored papers 1
Stanford University
Co-authored papers 1
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
University of Cambridge
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Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin
Co-authored papers 1
Carnegie Mellon University
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