Author details

Full Name

Atsushi Iwama

Affiliation

ORCID

Career Start Year

1991

Papers

276

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37544716	[Identification of transcriptional features and surface markers of plasma cell clones in POEMS syndrome by single-cell RNA sequencing].		2023
36352193	Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia.	Leukemia	2023
37793000	Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome.		2023
37553580	A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo.		2023
37464071	Correction: UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease.	Leukemia	2023
37266576	Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis.	Elife	2023
36813966	Chemically defined cytokine-free expansion of human haematopoietic stem cells.	Nature	2023
37198323	UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease.	Leukemia	2023
37071125	Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs.		2023
37069353	The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms.		2023
37007148	Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells.	Front Oncol	2023
34497325	Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis.	Leukemia	2022
35577813	Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.	Nature Communications	2022
35883630	Epigenetic Memories in Hematopoietic Stem and Progenitor Cells.	Cells	2022
35753219	YAP1/TAZ activity maintains vascular integrity and organismal survival.	Biochemical and Biophysical Research Communications	2022
35418614	Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of Î²-catenin degradation.	Leukemia	2022
36129760	Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis.	JCI insight	2022
35984905	Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias.	Blood	2022
36443290	PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.	Nat Commun	2022
36590688	A culture platform to study quiescent hematopoietic stem cells following genome editing.		2022
35240258	A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.	Exp Hematol	2022
35216063	Aging and Clonal Behavior of Hematopoietic Stem Cells.	International Journal of Molecular Sciences	2022
35212778	Wnt5a plays a critical role in anal opening in mice at an early stage of embryonic development.	Pediatric Surgery International	2022
34702814	Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.	Nature Communications	2021
37117524	Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice.		2021
33483574	The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells.	Scientific Reports	2021
34117255	Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.	Nature Communications	2021
33582241	Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.	Experimental Hematology	2021
33627520	Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome.	Aging	2021
34163066	Obesity accelerates hair thinning by stem cell-centric converging mechanisms.	Nature	2021
33674622	The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma.	Scientific Reports	2021
33452460	Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation.	Oncogene	2021
34087989	Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome.	Stem Cell Research	2021
33926240	CD271CD51PALLADIN Human Mesenchymal Stromal Cells Possess Enhanced Ossicle-Forming Potential.		2021
33496740	DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes.	Blood Adv	2021
32820269	PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.	Leukemia	2021
33231616	Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche.	Journal of Experimental Medicine	2021
33174606	UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.	Blood	2021
33406421	OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.	Cell Reports	2021
34861163	Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs.	Stem Cell Reports	2021
34725436	EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma.	Sci Rep	2021
31488559	Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells.	Haematologica	2020
32138671	Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study.	BMC Cardiovascular Disorders	2020
32126143	Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.	Blood Adv	2020
31679686	Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature.	Biochemical and Biophysical Research Communications	2020
32398456	Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.	Current Opinion in Hematology	2020
32341038	Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome.	Cancer Research	2020
33374737	Pathogenic Impacts of Dysregulated Polycomb Repressive Complex Function in Hematological Malignancies.	International Journal of Molecular Sciences	2020
33037737	Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome.	Cancer Sci	2020
33292805	Aging and leukemic evolution of hematopoietic stem cells under various stress conditions.	Inflammation and Regeneration	2020