Author details

Full Name

Andrew J Murphy

Affiliation

ORCID

Career Start Year

1983

Papers

182

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37523551	Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.		2023
37613478	Structural Analysis of Cancer-relevant TCR-CD3 and Peptide-MHC Complexes by CryoEM.		2023
37410813	A cellular and molecular spatial atlas of dystrophic muscle.		2023
37341346	VSIG4 interaction with heparan sulfates inhibits VSIG4-complement binding.		2023
36481478	IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline.		2023
36630481	Blocking common Î³ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.	Sci Transl Med	2023
37058568	IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.	Sci Adv	2023
36930708	Structural insights into the assembly of gp130 family cytokine signaling complexes.		2023
37100770	Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.		2023
37533642	TRAPnSeq allows high-throughput profiling of antigen-specific antibody-secreting cells.		2023
34988999	Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model.	Journal of Inherited Metabolic Disease	2022
35511419	Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.	Journal of Clinical Investigation	2022
36165182	IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice.	Journal of Immunology	2022
36350988	CD22-targeted CD28 bispecific antibody enhances antitumor efficacy of odronextamab in refractory diffuse large B cell lymphoma models.	Sci Transl Med	2022
35999217	Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.	Nat Commun	2022
35939579	Germline Mutations in <i>CIDEB</i> and Protection against Liver Disease.	N Engl J Med	2022
35668194	A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma.	Nature Cancer	2022
36476866	Cancer cell-derived type I interferons instruct tumor monocyte polarization.		2022
34126155	Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response.	Journal of Allergy and Clinical Immunology	2022
34755088	Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver.	iScience	2021
34161776	The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.	Cell	2021
33837124	Sequence of Î±PD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses.	Science immunology	2021
34210852	Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity.	Science	2021
34312491	Butyrophilin-like 2 regulates site-specific adaptations of intestinal Î³Î´ intraepithelial lymphocytes.	Communications Biology	2021
33288630	Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.	Journal of the American Society of Nephrology : JASN	2021
34919442	Humanization of T cell-mediated immunity in mice.	Science immunology	2021
34400331	Cell type-selective targeted delivery of a recombinant lysosomal enzyme for enzyme therapies.	Molecular Therapy	2021
34558178	Five-in-One: Simultaneous isolation of multiple major liver cell types from livers of normal and NASH mice.	Journal of Cellular and Molecular Medicine	2021
32553795	Activin A does not drive post-traumatic heterotopic ossification.		2020
31838750	Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4RÎ± antibody, is required to broadly inhibit type 2 inflammation.	Allergy: European Journal of Allergy and Clinical Immunology	2020
31879340	Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.	Proceedings of the National Academy of Sciences of the United States of America	2020
31770111	The anti-IgE mAb omalizumab induces adverse reactions by engaging FcÎ³ receptors.	Journal of Clinical Investigation	2020
31924685	Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory.	Science immunology	2020
31754927	The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells.	Angiogenesis	2020
31915305	A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies.	Science Translational Medicine	2020
33443029	Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine.	Science immunology	2020
32540904	Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies.	Science	2020
32540901	Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.	Science	2020
32646941	Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance.	Journal of Lipid Research	2020
33037066	REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.	Science	2020
32923116	Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.	OncoImmunology	2020
32641748	Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.	Communications Biology	2020
32581132	Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy.	Science Translational Medicine	2020
32515349	Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop.	eLife	2020
31395688	Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human -Knockin Mice.	Molecular Cancer Therapeutics	2019
31695028	An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.	Nature Communications	2019
31767870	Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.	Nature Communications	2019
31562870	IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation.	Journal of Allergy and Clinical Immunology	2019
30289441	Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct.	Biology of Reproduction	2019
31039396	Multifunctional Alleles: A novel method for the generation of "All-In-One" null and conditional alleles.	Methods	2019