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Author Details

Peter J Mullen
University of St Andrews
2010
21
17
PMIDPaper TitleJournal TitlePublished Year
37000221The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent.Cancer Chemother Pharmacol2023
36411320Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.Nat Cancer2022
33609439Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.Cell Metab2021
33767183SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.Nat Commun2021
32203069A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.Prostate Cancer Prostatic Dis2020
31023626An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer.Mol Metab2019
29229608Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins.Cancer Res2018
30197082Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.Cell2018
30300580MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.Cancer Cell2018
25300705Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo.Arch Toxicol2016
27562463The interplay between cell signalling and the mevalonate pathway in cancer.Nat Rev Cancer2016
25631767AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.Blood2015
26353928Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.Oncotarget2015
24337703Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells.Breast Cancer Res Treat2014
24994712Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.Cancer Res2014
24656129Largen: a molecular regulator of mammalian cell size control.Mol Cell2014
24030976MYC phosphorylation at novel regulatory regions suppresses transforming activity.Cancer Res2013
22743351Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans.Ther Drug Monit2012
21354273Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition.Neuroscience2011
21839782Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt.Biochim Biophys Acta2011
20018177Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy.Biochem Pharmacol2010
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Collaborators

Linda Z Penn
University of Toronto
Co-authored papers 10
Joseph Longo
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 4
Heather R Christofk
Jonsson Comprehensive Cancer Center, University of California los angeles
Co-authored papers 4
Carolyn A Goard
Princess Margaret Cancer Centre, Ontario Cancer Institute
Co-authored papers 3
Manpreet Kalkat
Van Andel Institute
Co-authored papers 3
Paul C Boutros
University of California los angeles
Co-authored papers 3
William B Tu
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 2
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 2
Michelle Chan-Seng-Yue
Princess Margaret Cancer Centre
Co-authored papers 2
Benjamin Haibe-Kains
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Theodorus H van der Kwast
University Health Network, University of Toronto
Co-authored papers 2
Neil E Fleshner
University of Toronto
Co-authored papers 2
Costas A Lyssiotis
Co-authored papers 2
Wail Ba-Alawi
Princess Margaret Cancer Centre, University Health Network, University Ave.
Co-authored papers 2
Dharmendra Dingar
Montreal Heart Institute Montreal Quebec Canada.
Co-authored papers 2
Aleksandra A Pandyra
Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf
Co-authored papers 2
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Amanda R Wasylishen
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Mehdi Masoomian
University Health Network
Co-authored papers 2
Yu-Jia Shiah
Ontario Institute for Cancer Research
Co-authored papers 1
Andrew J Elia
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 1
John E Dick
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Wei Xu
Princess Margaret Cancer Centre
Co-authored papers 1
Marcela Gronda
Princess Margaret Cancer Centre
Co-authored papers 1
Kevin R Brown
College Street, University of Toronto
Co-authored papers 1
Syed Haider
Institute of Cancer Research
Co-authored papers 1
David W Andrews
Sunnybrook Research Institute, University of Toronto
Co-authored papers 1
Samuel W French
David Geffen School of Medicine, University of California at Los Angeles
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Ivan Topisirovic
McGill University
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Release 1.2