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Author Details

Patrick R Griffin
The Scripps Research Institute
1987
280
72
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37267907Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.Mol Cell2023
37490546Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.Sci Signal2023
37322867Assembly of JAZ-JAZ and JAZ-NINJA complexes in jasmonate signaling.Plant Commun2023
37181042Osteocytes contribute <i>via</i> nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism.Front Endocrinol (Lausanne)2023
37146157PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.ACS Chem Biol2023
37379434Hydrogen-Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase.Anal Chem2023
34793198Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.Science2022
35437807The intrinsically disordered CARDs-Helicase linker in RIG-I is a molecular gate for RNA proofreading.EMBO J2022
35503419Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.J Med Chem2022
36442911Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia.J Immunother Cancer2022
36490335Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro.Sci Adv2022
36202818Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.Nat Commun2022
36227956RORβ modulates a gene program that is protective against articular cartilage damage.PLoS One2022
36378961Molecular glue CELMoD compounds are regulators of cereblon conformation.Science2022
35155940Identification and Optimization of a Novel HIV-1 Integrase Inhibitor.ACS Omega2022
35214145Discovery and Characterization of a New Crustin Antimicrobial Peptide from <i>Amphibalanus amphitrite</i>.Pharmaceutics2022
35308855Discovery of an NAD<sup>+</sup> analogue with enhanced specificity for PARP1.Chem Sci2022
33434430Structure-Activity Relationship and Biological Investigation of SR18292 (<b>16</b>), a Suppressor of Glucagon-Induced Glucose Production.J Med Chem2021
33571111Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ.Sci Adv2021
33753480CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.Proc Natl Acad Sci U S A2021
33722775PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss.Bone2021
33688660Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics.bioRxiv2021
33524253A Bifunctional NAD<sup>+</sup> for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins.ACS Chem Biol2021
34558887Discovery of Selective Inhibitors for <i>In Vitro</i> and <i>In Vivo</i> Interrogation of Skeletal Myosin II.ACS Chem Biol2021
34437114Structure of an AMPK complex in an inactive, ATP-bound state.Science2021
34644557Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.Immunity2021
34521837One-step construction of circularized nanodiscs using SpyCatcher-SpyTag.Nat Commun2021
34403472Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).Nucleic Acids Res2021
34452998Dual-mechanism estrogen receptor inhibitors.Proc Natl Acad Sci U S A2021
34130216Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.Bioorg Med Chem2021
34121407Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics.J Am Soc Mass Spectrom2021
34050165Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.Nat Commun2021
32320665A Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels.Cell Rep2020
33870216Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer.Curr Res Struct Biol2020
32075969A molecular switch regulating transcriptional repression and activation of PPARγ.Nat Commun2020
31943114Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase.Nucleic Acids Res2020
33060363Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.Science2020
33188783A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone.J Mol Biol2020
33043784High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2.SLAS Discov2020
33067423Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6.Nat Commun2020
33204739A simple and robust cell-based assay for the discovery of novel cytokinesis inhibitors.J Biol Methods2020
32658454Comparative Analysis of Cleavage Specificities of Immobilized Porcine Pepsin and Nepenthesin II under Hydrogen/Deuterium Exchange Conditions.Anal Chem2020
30416039Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1.Structure2019
31724102A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.J Am Soc Mass Spectrom2019
31780431Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures.Structure2019
31862968Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ.Nat Commun2019
30142014Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay.SLAS Discov2019
31299203Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.Cell2019
31611383Quantitative structural assessment of graded receptor agonism.Proc Natl Acad Sci U S A2019
31351767Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry.Curr Opin Struct Biol2019
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Collaborators

Theodore M Kamenecka
Co-authored papers 49
Michael J Chalmers
Lilly Research Laboratories
Co-authored papers 41
Bruce D Pascal
The Scripps Research Institute
Co-authored papers 41
Timothy S Strutzenberg
Salk Institute for Biological Studies
Co-authored papers 17
David Marciano
Stanford Cardiovascular Institute (L.W., Stanford University School of Medicine
Co-authored papers 14
Jeffrey Shabanowitz
University of Virginia
Co-authored papers 13
Donald F Hunt
University of Virginia
Co-authored papers 13
Jeffrey A Dodge
Lilly Research Laboratories
Co-authored papers 12
John R Yates
TheScripps Research Institute
Co-authored papers 9
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 7
Hualiang Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Co-authored papers 4
Steven P Gygi
Harvard Medical School
Co-authored papers 4
Daniel K Nomura
University of California berkeley
Co-authored papers 3
Emad Tajkhorshid
University of Illinois at Urbana-Champaign
Co-authored papers 3
Dušica VidoviĿ
Co-authored papers 3
Howard Broughton
Lilly Research Laboratories
Co-authored papers 3
Alfonso Espada
Co-authored papers 3
Gye Won Han
Bridge Institute, University of Southern California
Co-authored papers 3
Stephan C Sch??rer
Institute for Data Science and Computing, University of Miami
Co-authored papers 3
Bridget Carragher
Columbia University
Co-authored papers 3
Clifford J Rosen
Maine Medical Center Research Institute
Co-authored papers 3
Lynda F Bonewald
Indiana Center for Musculoskeletal Health, Indiana University School of Medicine
Co-authored papers 2
Benjamin F Cravatt
Scripps Research Institute
Co-authored papers 2
Jimmy K Eng
University of Washington
Co-authored papers 2
Jie J Zheng
Molecular Biology Institute, University of California los angeles
Co-authored papers 2
Bert W O'Malley
Center for Coregulator Research, Baylor College of Medicine
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Nathan A Yates
University of Pittsburgh School of Medicine
Co-authored papers 2
Joshua A Bittker
Co-authored papers 2
Stuart L Schreiber
Broad Institute
Co-authored papers 2
Release 1.2