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Author Details

Valerian E Kagan
Center for Free Radical and Antioxidant Health, University of Pittsburgh
1969
660
92
PMIDPaper TitleJournal TitlePublished Year
37154783Vitamin E/Coenzyme Q-Dependent "Free Radical Reductases": Redox Regulators in Ferroptosis.Antioxid Redox Signal2024
36868224Functional states of myeloid cells in cancer.Cancer Cell2023
37996701Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.Nat Metab2023
37782815Vitamin C Is Mandatory for the Tricarboxylic Acid Cycle Production of Antiinflammatory Itaconate.Am J Respir Crit Care Med2023
37678654Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs.Free Radic Biol Med2023
37212279The lipase cofactor CGI58 controls placental lipolysis.JCI Insight2023
37245287Formation of protein adducts with Hydroperoxy-PE electrophilic cleavage products during ferroptosis.Redox Biol2023
37103240Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe.J Am Chem Soc2023
36998620Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production.Oncoimmunology2023
37327313Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.Proc Natl Acad Sci U S A2023
36922653Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney.Nat Rev Nephrol2023
36870109Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo.Redox Biol2023
36933393Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death.Redox Biol2023
33414166Ferroptosis induces membrane blebbing in placental trophoblasts.J Cell Sci2022
35760871Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo.Nat Metab2022
35725581Detection of HOCl-driven degradation of the pericardium scaffolds by label-free multiphoton fluorescence lifetime imaging.Sci Rep2022
36711215Nitrogen-Doped Carbon Nanotube Cups for Cancer Therapy.ACS Appl Nano Mater2022
36385526Ferroptosis of tumour neutrophils causes immune suppression in cancer.Nature2022
35101798Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death.Redox Biol2022
35041620P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.JCI Insight2022
35238643Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury.Proc Natl Acad Sci U S A2022
35171671Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60.Sci Adv2022
34764204Myeloid Cell-Derived Oxidized Lipids and Regulation of the Tumor Microenvironment.Cancer Res2022
3476260215LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.J Clin Invest2022
34817556C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria.J Cell Biol2022
34740873Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.Transl Res2022
32438524Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis.Hepatology2021
33854057Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.Nat Commun2021
33684237Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS).Angew Chem Int Ed Engl2021
33542532Phospholipase iPLA<sub>2</sub>β averts ferroptosis by eliminating a redox lipid death signal.Nat Chem Biol2021
33679610Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation.Front Endocrinol (Lausanne)2021
34592565Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure.Redox Biol2021
34102574Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes.Redox Biol2021
34075742Successive High-Resolution (H<sub>2</sub>O)<sub><i>n</i></sub>-GCIB and C<sub>60</sub>-SIMS Imaging Integrates Multi-Omics in Different Cell Types in Breast Cancer Tissue.Anal Chem2021
34099706Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease.Nat Commun2021
34244497Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.Nat Commun2021
34067535NO<sup>⿏</sup> Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis.Int J Mol Sci2021
34033821Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids.J Mol Biol2021
34167028A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO<sup>â¿¢</sup> sabotage of theft-ferroptosis.Redox Biol2021
33126055Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis.Redox Biol2021
32941182Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation.J Clin Invest2021
30520681Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision.J Neurotrauma2020
32080625Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.Nat Chem Biol2020
33087576PLA2G6 guards placental trophoblasts against ferroptotic injury.Proc Natl Acad Sci U S A2020
33110056Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis.Cell Death Dis2020
33268511Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils.Sci Transl Med2020
32803946Photoluminescence Response in Carbon Nanomaterials to Enzymatic Degradation.Anal Chem2020
32732285Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.J Biol Chem2020
32584791Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer.JCI Insight2020
32219161Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials.Sci Adv2020
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Collaborators

Patrick M Kochanek
University of Pittsburgh School of Medicine
Co-authored papers 40
Simon C Watkins
Center for Molecular Imaging, University of Pittsburgh School of Medicine
Co-authored papers 29
Judith Klein-Seetharaman
School of Molecular Sciences & College of Health Solutions, Arizona State University
Co-authored papers 26
Ivet Bahar
Laufer Center for Physical and Quantitative Biology, Stony Brook University
Co-authored papers 22
Nikolai V Gorbunov
Armed Forces Radiobiology Research Institute
Co-authored papers 19
Robert S B Clark
University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh
Co-authored papers 18
Nina F Schor
National Institute of Neurological Disorders and Stroke
Co-authored papers 17
Nabil M Elsayed
SUNY Down State Medical Center
Co-authored papers 12
Radoslav Goldman
Co-authored papers 11
Andrew P VanDemark
University of Pittsburgh
Co-authored papers 7
Dipak K Das
S.N. Bose National Centre for Basic Sciences
Co-authored papers 6
Brent R Stockwell
Columbia University
Co-authored papers 6
Mitchell P Fink
University of Pittsburgh School of Medicine
Co-authored papers 6
Timothy R Billiar
University of Pittsburgh
Co-authored papers 5
John A Kellum
Spectral Medical Inc.
Co-authored papers 5
Ian Martin
Jungers Center for Neurosciences, Oregon Health and Science University
Co-authored papers 5
Stephen R Wisniewski
Graduate School of Public Health, University of Pittsburgh
Co-authored papers 5
Nilanjana Maulik
University of Connecticut Health
Co-authored papers 5
P. David Adelson
Barrow Neurological Institute at Phoenix Children's Hospital
Co-authored papers 4
Rosa Viner
University of California (Davis)
Co-authored papers 4
Tian Tian
Beijing Friendship Hospital, Capital Medical University
Co-authored papers 4
Andrew V Kossenkov
The Wistar Institute
Co-authored papers 4
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 4
Richard M Engelman
University of Massachusetts Medical School-Baystate
Co-authored papers 3
Masazumi Watanabe
Hiroshima University Hospital
Co-authored papers 3
Daniel Engelman
University of Massachusetts Medical School-Baystate
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David O Okonkwo
University of Pittsburgh Medical Center
Co-authored papers 2
Samuel M Poloyac
University of Texas
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Release 1.2