Author details

Full Name

Peter B Dervan

Affiliation

ORCID

Career Start Year

1982

Papers

234

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35022237	RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.	Proceedings of the National Academy of Sciences of the United States of America	2022
34552311	Repression of the transcriptional activity of ERRÎ± with sequence-specific DNA-binding polyamides.	Medicinal Chemistry Research	2020
33351840	Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome.	PLoS ONE	2020
30838415	Sequence specific suppression of androgen receptor-DNA binding in vivo by a Py-Im polyamide.	Nucleic Acids Research	2019
29715291	Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide.	PLoS One	2018
29168508	Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.	Nature	2017
28360139	A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer.	Cancer Res	2017
27791148	RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.	Proc Natl Acad Sci U S A	2016
26801054	A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.	Molecular Cancer Research	2016
27425605	Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.	Cell Rep	2016
26719577	An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors.	Molecular Cancer Therapeutics	2016
27609878	Ahmed H. Zewail (1946-2016).	Science	2016
26571387	Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.	PLoS One	2015
26537405	A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma.	Quarterly Reviews of Biophysics	2015
25238175	Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted.	Journal of Medicinal Chemistry	2014
24502234	Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition.	Journal of the American Chemical Society	2014
24780272	A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.	Bioorganic and Medicinal Chemistry	2014
25249630	Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.	Nucleic Acids Res	2014
23106218	Synthesis of cyclic Py-Im polyamide libraries.	Journal of Organic Chemistry	2013
22987334	Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.	Angewandte Chemie - International Edition	2013
24015881	Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.	J Med Chem	2013
23443804	Activity of a Py-Im polyamide targeted to the estrogen response element.	Mol Cancer Ther	2013
23359708	Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.	Proc Natl Acad Sci U S A	2013
23319609	Antitumor activity of a pyrrole-imidazole polyamide.	Proc Natl Acad Sci U S A	2013
22080545	Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.	Nucleic Acids Research	2012
22509786	Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.	Journal of the American Chemical Society	2012
22798143	Role of mismatch repair enzymes in GAAÂ·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.	Journal of Biological Chemistry	2012
22578091	Microwave assisted synthesis of Py-Im polyamides.	Organic Letters	2012
22907527	Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.	Cancer Chemother Pharmacol	2012
23013524	Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.	J Am Chem Soc	2012
22988074	Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.	Proc Natl Acad Sci U S A	2012
22607671	Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.	Bioorganic and Medicinal Chemistry Letters	2012
22607187	Characterization and solubilization of pyrrole-imidazole polyamide aggregates.	Journal of Medicinal Chemistry	2012
22203967	Modulation of NF-ÎºB-dependent gene transcription using programmable DNA minor groove binders.	Proceedings of the National Academy of Sciences of the United States of America	2012
21957930	Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA.	Organic Letters	2011
22039883	Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.	Biochemistry	2011
20812704	Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.	Journal of the American Chemical Society	2010
19413319	Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.	J Am Chem Soc	2009
19486688	Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray.	Biophysical Journal	2009
19627138	Oligomerization route to Py-Im polyamide macrocycles.	Org Lett	2009
19349175	DNA sequence selectivity of hairpin polyamide turn units.	Bioorganic and Medicinal Chemistry Letters	2009
19572551	Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.	Journal of Medicinal Chemistry	2009
19666554	Allosteric modulation of DNA by small molecules.	Proceedings of the National Academy of Sciences of the United States of America	2009
19805343	Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression.	Proc Natl Acad Sci U S A	2009
19413320	Solution-phase synthesis of pyrrole-imidazole polyamides.	J Am Chem Soc	2009
18753620	In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.	Proc Natl Acad Sci U S A	2008
18524590	Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells.	Bioorganic and Medicinal Chemistry Letters	2008
18422304	Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly.	ACS Chemical Biology	2008
18459783	Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.	Journal of the American Chemical Society	2008
18081289	Programming multiple protein patterns on a single DNA nanostructure.	Journal of the American Chemical Society	2008