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Author Details

Zhexing Wen
Emory University School of Medicine
2003
71
32
PMIDPaper TitleJournal TitlePublished Year
35759110Modeling tuberous sclerosis complex with human induced pluripotent stem cells.World J Pediatr2024
36747819Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.bioRxiv2023
37585521Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.Sci Adv2023
37503019Leveraging Generative AI to Prioritize Drug Repurposing Candidates: Validating Identified Candidates for Alzheimer's Disease in Real-World Clinical Datasets.Res Sq2023
374534192-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience.Neuron2023
37171075APOE expression and secretion are modulated by mitochondrial dysfunction.Elife2023
37236404Electrophysiological and morphological characterization of single neurons in intact human brain organoids.J Neurosci Methods2023
37301236The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.Brain Behav Immun2023
35264726Schizophrenia: a disorder of broken brain bioenergetics.Mol Psychiatry2022
35649379Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model.Cell Rep2022
35681419Across Dimensions: Developing 2D and 3D Human iPSC-Based Models of Fragile X Syndrome.Cells2022
36417528Expression of expanded GGC repeats within <i>NOTCH2NLC</i> causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease.Sci Adv2022
36313465Editorial: Genetics and epigenetics of psychiatric diseases-volume II.Front Genet2022
35921164The mitochondrial RNA granule modulates manganese-dependent cell toxicity.Mol Biol Cell2022
31444471Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.Mol Psychiatry2021
339100005-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.Cell Rep2021
33852833Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.Cell Rep2021
33875724Induced pluripotent stem cells from subjects with Lesch-Nyhan disease.Sci Rep2021
33931639Author Correction: Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation.Nat Commun2021
33658519Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation.Nat Commun2021
34539790Brain Organoids: Studying Human Brain Development and Diseases in a Dish.Stem Cells Int2021
34413513A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.Nat Neurosci2021
34261699Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus.J Neurosci2021
32015466LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia.Mol Psychiatry2021
33411227Role of Astrocytes in Major Neuropsychiatric Disorders.Neurochem Res2021
32753686TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.Mol Psychiatry2021
32375063Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.Neuron2020
32057360Targeting Hsc70-based autophagy to eliminate amyloid β oligomers.Biochem Biophys Res Commun2020
32794569Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.Hum Mol Genet2020
32592681Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases.Mol Cell2020
30338483Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments.Mol Neurobiol2019
35308096Mechanisms Underlying Dysregulation of miR-132 in Alzheimer's Disease.Biomed J Sci Tech Res2019
31375586Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication.J Virol2019
30988527A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data.Nat Neurosci2019
31066577Altered DNA methylation of the <i>Alu</i>Y subfamily in schizophrenia and bipolar disorder.Epigenomics2019
30833507Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.J Neurosci2019
30911039Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia.Sci Rep2019
31106784Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia.Mol Omics2019
31019524Epigenetic Regulations in Neuropsychiatric Disorders.Front Genet2019
28758997Zika virus directly infects peripheral neurons and induces cell death.Nat Neurosci2017
28186671Modeling neurodevelopmental and psychiatric diseases with human iPSCs.J Neurosci Res2017
28472294Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.Hum Mol Genet2017
28441409A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model.PLoS One2017
29249816Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development.Transl Psychiatry2017
29100013Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.Cell Stem Cell2017
28566536How does Zika virus cause microcephaly?Genes Dev2017
28826723Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.Cell Stem Cell2017
27050588Patient iPSCs: a new discovery tool for Smith-Lemli-Opitz syndrome.Nat Med2016
27118425Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.Cell2016
27571349Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.Nat Med2016
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Collaborators

Peng Jin
Co-authored papers 8
Tianlei Xu
Emory University
Co-authored papers 2
Riki Kawaguchi
Co-authored papers 2
Pei-Yong Shi
University of Texas Medical Branch
Co-authored papers 2
Daniel R Weinberger
Co-authored papers 2
Jarek Meller
Co-authored papers 2
David A Lewis
University of Pittsburgh
Co-authored papers 2
Linzhao Cheng
Johns Hopkins University School of Medicine
Co-authored papers 2
Nancy J Cox
Vanderbilt University Medical Center
Co-authored papers 1
Edwin H Cook
Co-authored papers 1
Jeremy M Boss
Emory University School of Medicine
Co-authored papers 1
Allan I Levey
Emory University School of Medicine
Co-authored papers 1
Robert A Brodsky
Sidney Kimmel Cancer Center, Johns Hopkins University
Co-authored papers 1
Hu Li
Co-authored papers 1
Leslie G Biesecker
National Human Genome Research Institute, National Institutes of Health
Co-authored papers 1
Alyson L Dickson
Vanderbilt University Medical Center
Co-authored papers 1
Xue Zhong
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Vahram Haroutunian
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Ashok R Dinasarapu
Co-authored papers 1
Chao Yan
Vanderbilt University Medical Center
Co-authored papers 1
Helena T Hogberg
Co-authored papers 1
Lena Smirnova
Co-authored papers 1
Tania F Gendron
Co-authored papers 1
Li Chen
Indiana University School of Medicine
Co-authored papers 1
Thomas Hartung
University of Konstanz
Co-authored papers 1
David M Gilbert
Co-authored papers 1
Alison M Goate
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
In Young Choi
The Catholic University of Korea College of Medicine
Co-authored papers 1
Joanna M Biernacka
Mayo Clinic
Co-authored papers 1
Rui Chen
Co-authored papers 1
Release 1.2