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Author Details

Edwin Cuppen
Hartwig Medical Foundation
1997
286
79
PMIDPaper TitleJournal TitlePublished Year
36621142Identifying somatic changes in drug transporters using whole genome and transcriptome sequencing data of advanced tumors.Biomed Pharmacother2023
37686693Genomic Alterations Associated with Estrogen Receptor Pathway Activity in Metastatic Breast Cancer Have a Differential Impact on Downstream ER Signaling.Cancers (Basel)2023
37106015The genome-wide mutational consequences of DNA hypomethylation.Sci Rep2023
37400554The genomic and transcriptomic landscape of advanced renal cell cancer for individualized treatment strategies.Sci Rep2023
37165135Genetic immune escape landscape in primary and metastatic cancer.Nat Genet2023
36656928Heritable defects in telomere and mitotic function selectively predispose to sarcomas.Science2023
34256129Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology.Semin Cancer Biol2022
35710704Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer.Sci Rep2022
35792649Feasibility of whole-genome sequencing-based tumor diagnostics in routine pathology practice.J Pathol2022
35662281Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests.Oncogene2022
35817764Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features.Nat Commun2022
35389777Genome-wide analysis of somatic noncoding mutation patterns in cancer.Science2022
36480778Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care.JCO Precis Oncol2022
36776527Unscrambling cancer genomes via integrated analysis of structural variation and copy number.Cell Genom2022
36463731Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics.ESMO Open2022
36481665Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.Nat Commun2022
36207433Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue.Nat Commun2022
36333718Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics-a prospective multicenter cohort study.BMC Med Genomics2022
36050473Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.Nature2022
35046062Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment.Clin Cancer Res2022
35246937Different responses to DNA damage determine ageing differences between organs.Aging Cell2022
35086719Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma.Eur Urol2022
35326660Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer.Cancers (Basel)2022
35168570MutationalPatterns: the one stop shop for the analysis of mutational processes.BMC Genomics2022
34175442Clinical utility of whole-genome sequencing in precision oncology.Semin Cancer Biol2022
34119643Analytical demands to use whole-genome sequencing in precision oncology.Semin Cancer Biol2022
34253237GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing.Genome Biol2021
33910430Early technology assessment of using whole genome sequencing in personalized oncology.Expert Rev Pharmacoecon Outcomes Res2021
33852815Micro-costing diagnostics in oncology: from single-gene testing to whole- genome sequencing.Expert Rev Pharmacoecon Outcomes Res2021
33887686Prospective experimental treatment of colorectal cancer patients based on organoid drug responses.ESMO Open2021
33495476Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features.Nat Commun2021
34795391Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.Commun Biol2021
34131135Learning mutational signatures and their multidimensional genomic properties with TensorSignatures.Nat Commun2021
34326338The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets.Nat Commun2021
33964451Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics.J Mol Diagn2021
34039979Author Correction: Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features.Nat Commun2021
34211178Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns.Nat Genet2021
34373653Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.Nat Med2021
31089205Biallelic variants in POLR3GL cause endosteal hyperostosis and oligodontia.Eur J Hum Genet2020
32024849A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.Nat Commun2020
32094484Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples.Br J Cancer2020
33087703Single-cell derived tumor organoids display diversity in HLA class I peptide presentation.Nat Commun2020
33167975Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE).BMC Med Genomics2020
33149131Pan-cancer landscape of homologous recombination deficiency.Nat Commun2020
33318612Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.Sci Rep2020
32753580Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells.Nat Commun2020
32553164Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses.Cell Rep2020
32358202SARS-CoV-2 productively infects human gut enterocytes.Science2020
32494621Sperm DNA damage causes genomic instability in early embryonic development.Sci Adv2020
32375033Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine.Cell Rep2020
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Collaborators

Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 31
Emile E Voest
The Netherlands Cancer Institute
Co-authored papers 31
Martijn P Lolkema
Erasmus MC Cancer Institute
Co-authored papers 21
Eugene Berezikov
Co-authored papers 18
Stefan Sleijfer
Erasmus MC Cancer Institute, University Medical Center Rotterdam
Co-authored papers 14
Neeltje Steeghs
Netherlands Cancer Institute-Antoni Van Leeuwenhoek
Co-authored papers 14
Norbert H??bner
Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 12
John W M Martens
Erasmus Medical Center (MC) Cancer Institute
Co-authored papers 9
Marc van de Wetering
Princess Maxima Center for Pediatric Oncology
Co-authored papers 8
Job van Riet
Erasmus MC Cancer Institute
Co-authored papers 8
Harmen J G van de Werken
Department of Immunology Erasmus University Medical Center
Co-authored papers 8
Lodewyk F A Wessels
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Co-authored papers 8
Paul J van Diest
University Medical Center Utrecht
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Charles G Mullighan
St Jude Children's Research Hospital
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Jeroen de Ridder
Center for Molecular Medicine, University Medical Center Utrecht
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Paul Flicek
European Bioinformatics Institute
Co-authored papers 4
Howard J Jacob
Genomics Research Center
Co-authored papers 4
Torsten Haferlach
Taussig Cancer Institute, Cleveland Clinic
Co-authored papers 4
Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 4
Pjotr Prins
Wageningen University & Research
Co-authored papers 4
Olivier Elemento
Meyer Cancer Center
Co-authored papers 4
Gerrit A Meijer
The Netherlands Cancer Institute
Co-authored papers 4
Matthias Heinig
Co-authored papers 4
Sean M Grimmond
The University of Melbourne
Co-authored papers 4
Serena Nik-Zainal
Early Cancer Institute, University of Cambridge
Co-authored papers 4
Sebastian Schafer
Co-authored papers 4
Albert J R Heck
Utrecht University
Co-authored papers 4
Jos Jonkers
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 4
Carlos Caldas
Cancer Research UK Cambridge Institute, University of Cambridge
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Derek L Stemple
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Release 1.2