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Author Details

Sharon E Heath
Washington University School of Medicine.
2003
43
30
PMIDPaper TitleJournal TitlePublished Year
36711871Genomic landscape of <i>TP53</i> -mutated myeloid malignancies.medRxiv2023
37160317Melanoma in a patient with DNMT3A overgrowth syndrome.Cold Spring Harb Mol Case Stud2023
37339484Genomic landscape of TP53-mutated myeloid malignancies.Blood Adv2023
34788385DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.Blood2022
35709710Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.Blood Cancer Discov2022
35675516IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.Blood2022
34873300Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.Leukemia2022
35019859Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.Blood Cancer Discov2022
34315901Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.Nat Commun2021
33704937Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.N Engl J Med2021
34845035Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.Proc Natl Acad Sci U S A2021
30467844Exome analysis of treatment-related AML after APL suggests secondary evolution.Br J Haematol2019
29515031Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.JCI Insight2018
30207916Mutation Clearance after Transplantation for Myelodysplastic Syndrome.N Engl J Med2018
30380364Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.N Engl J Med2018
29386642Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.Nat Commun2018
29567774Lenalidomide results in a durable complete remission in acute myeloid leukemia accompanied by persistence of somatic mutations and a T-cell infiltrate in the bone marrow.Haematologica2018
27740633Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.Leukemia2017
28215704CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.Cell2017
27181063Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.Exp Hematol2016
26631115Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.Blood2016
27959731TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.N Engl J Med2016
27573557Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.Leukemia2016
25487151Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.Nature2015
26305651Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.JAMA2015
26492932Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.Blood2015
25644247Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.Leukemia2015
25010716Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.PLoS Genet2014
23443460Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.Leukemia2013
23634996Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.N Engl J Med2013
22417201Clonal architecture of secondary acute myeloid leukemia.N Engl J Med2012
22817890The origin and evolution of mutations in acute myeloid leukemia.Cell2012
22237025Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.Nature2012
21505135Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.JAMA2011
22158538Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.Nat Genet2011
21505136Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.JAMA2011
21067377DNMT3A mutations in acute myeloid leukemia.N Engl J Med2010
19651600Acquired copy number alterations in adult acute myeloid leukemia genomes.Proc Natl Acad Sci U S A2009
19657110Recurring mutations found by sequencing an acute myeloid leukemia genome.N Engl J Med2009
18160671Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.Blood2008
18987736DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.Nature2008
18270328Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.Blood2008
14614138A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.Proc Natl Acad Sci U S A2003
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Collaborators

Timothy J Ley
Washington University School of Medicine
Co-authored papers 41
Daniel C Link
Washington University School of Medicine
Co-authored papers 36
John F DiPersio
Washington University School of Medicine
Co-authored papers 34
Robert S Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 34
Peter Westervelt
Washington University School of Medicine
Co-authored papers 34
Matthew J Walter
Washington University School of Medicine in St. Louis
Co-authored papers 34
Christopher A Miller
Washington University School of Medicine
Co-authored papers 28
Timothy A Graubert
Massachusetts General Hospital
Co-authored papers 26
Richard K Wilson
The Ohio State University
Co-authored papers 25
Jacqueline E Payton
Washington University School of Medicine.
Co-authored papers 22
Elaine R Mardis
The Ohio State University
Co-authored papers 19
Michelle O'Laughlin
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 17
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 16
Michael D McLellan
McDonnell Genome Institute, Washington University in St. Louis
Co-authored papers 14
Li Ding
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 13
Mark A Watson
Washington University School of Medicine
Co-authored papers 11
David E Larson
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 11
David H Spencer
Washington University School of Medicine.
Co-authored papers 10
Daniel C Koboldt
Institute for Genomic Medicine, Nationwide Children's Hospital
Co-authored papers 10
Lukas D Wartman
Washington University School of Medicine in St. Louis
Co-authored papers 9
Vincent Magrini
The Ohio State University
Co-authored papers 9
Ken Chen
University of Texas MD Anderson Cancer Center
Co-authored papers 8
Lucinda Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 8
Jeffery M Klco
St. Jude Children's Research Hospital
Co-authored papers 8
Tamara L Lamprecht
St. Jude Children's Research Hospital
Co-authored papers 8
Rakesh Nagarajan
Current or past members of the College of American Pathologists
Co-authored papers 8
Shashikant Kulkarni
Centene Center for Health Transformation, Centene Corporation
Co-authored papers 7
Sean McGrath
Harvard T.H. Chan School of Public Health
Co-authored papers 6
Rhonda E Ries
Clinical Research Division, Fred Hutchinson Cancer Research Center
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Matthew J Christopher
Washington University School of Medicine
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Release 1.2