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Author Details

Amy C Sims
The University of North Carolina at Chapel Hill
1998
73
39
PMIDPaper TitleJournal TitlePublished Year
37293202Editorial: The gut microbiome and COVID-19.Front Cell Infect Microbiol2023
37634194Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.J Proteome Res2023
37193127Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection.iScience2023
36311275Detection of SARS-COV-2 by functionally imprinted micelles.MRS Commun2022
34026476Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis.Algal Res2021
33488611Genetic Dissection of the Regulatory Mechanisms of <i>Ace2</i> in the Infected Mouse Lung.Front Immunol2021
34832652Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone.Pathogens2021
34051754Hypergraph models of biological networks to identify genes critical to pathogenic viral response.BMC Bioinformatics2021
34372702Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury.mBio2021
31628848Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development.J Infect Dis2020
31924756Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.Nat Commun2020
31883096Metabolite, Protein, and Lipid Extraction (MPLEx): A Method that Simultaneously Inactivates Middle East Respiratory Syndrome Coronavirus and Allows Analysis of Multiple Host Cell Components Following Infection.Methods Mol Biol2020
33046644Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection.Proc Natl Acad Sci U S A2020
32253226An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.Sci Transl Med2020
30974127Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.Antiviral Res2019
31616667The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections.Front Cell Dev Biol2019
31578288Small-Molecule Antiviral β-d-N[4]-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.J Virol2019
31233808Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.Antiviral Res2019
29339515MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.Proc Natl Acad Sci U S A2018
30541777The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis.mSphere2018
29511076Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.mBio2018
28659436Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.Sci Transl Med2017
28091625MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling.Analyst2017
29152578Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.mSphere2017
27025250Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.mBio2016
27822525MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses.mSystems2016
27504778Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.Nat Biotechnol2016
26976607SARS-like WIV1-CoV poised for human emergence.Proc Natl Acad Sci U S A2016
25926653Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme.J Virol2015
24846384Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.mBio2014
25977790A comprehensive collection of systems biology data characterizing the host response to viral infection.Sci Data2014
23275571RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus.Nucleic Acids Res2013
24043791Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.Proc Natl Acad Sci U S A2013
23935999A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.PLoS One2013
23682300A Simulation Framework to Investigate <i>in vitro</i> Viral Infection Dynamics.J Comput Sci2013
23365422Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.J Virol2013
23334702Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production.Viruses2013
21852304Improved quality control processing of peptide-centric LC-MS proteomics data.Bioinformatics2011
32288900A Simulation Framework to Investigate <i>in vitro</i> Viral Infection Dynamics.Procedia Comput Sci2011
20719951Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures.J Virol2010
21079686Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.PLoS Pathog2010
17451829SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium.Virus Res2008
18818320Systematic assembly of a full-length infectious clone of human coronavirus NL63.J Virol2008
19036930Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.Proc Natl Acad Sci U S A2008
19057869Systematic assembly and genetic manipulation of the mouse hepatitis virus A59 genome.Methods Mol Biol2008
18367528Persistent replication of severe acute respiratory syndrome coronavirus in human tubular kidney cells selects for adaptive mutations in the membrane protein.J Virol2008
18094188Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium.J Virol2008
17397959SARS coronavirus replicase proteins in pathogenesis.Virus Res2008
17392363Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.J Virol2007
18005686A Reverse genetics system for dsRNA viruses.Cell Host Microbe2007
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Collaborators

University of North Carolina
Co-authored papers 59
Vanderbilt University Medical Center
Co-authored papers 21
University of North Carolina at Chapel Hill
Co-authored papers 19
University of North Carolina
Co-authored papers 16
Pacific Northwest National Laboratory
Co-authored papers 13
Co-authored papers 12
Marsico Lung Institute, University of North Carolina-Chapel Hill
Co-authored papers 11
Pacific Northwest National Laboratory
Co-authored papers 11
Pacific Northwest National Laboratory
Co-authored papers 9
University of North Carolina at Chapel Hill
Co-authored papers 9
University of Texas Medical Branch
Co-authored papers 9
Pacific Northwest National Laboratory
Co-authored papers 8
Influenza Research Institute, University of Wisconsin-Madison
Co-authored papers 7
Influenza Research Institute, University of Wisconsin
Co-authored papers 7
Pacific Northwest National Laboratory (PNNL)
Co-authored papers 7
Pacific Northwest National Laboratory
Co-authored papers 6
Co-authored papers 5
Pacific Northwest National Laboratory
Co-authored papers 5
Pacific Northwest National Laboratory
Co-authored papers 5
University of North Carolina at Chapel Hill
Co-authored papers 5
University of North Carolina at Chapel Hill
Co-authored papers 5
Pacific Northwest National Laboratory
Co-authored papers 5
Pacific Northwest National Laboratory
Co-authored papers 5
Center for Innate Immunity and Immune Disease, University of Washington
Co-authored papers 4
Co-authored papers 4
Oregon Health & Science University, University of California Berkeley
Co-authored papers 4
University of Washington
Co-authored papers 4
Pacific Northwest National Laboratory
Co-authored papers 4
Pacific Northwest National Laboratory
Co-authored papers 4
Oregon State University
Co-authored papers 4