Author details

Full Name

Melissa J Moore

Affiliation

ORCID

Career Start Year

1982

Papers

121

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36357718	An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts.	Nature Biotechnology	2023
35847173	Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.	Mol Ther Nucleic Acids	2022
33941243	Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways.		2021
34019945	Impact of lipid nanoparticle size on mRNA vaccine immunogenicity.	Journal of Controlled Release	2021
30785039	Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines.	Molecular Therapy - Nucleic Acids	2019
31697236	Free circular introns with an unusual branchpoint in neuronal projections.	eLife	2019
31712433	mRNA structure regulates protein expression through changes in functional half-life.	Proceedings of the National Academy of Sciences of the United States of America	2019
30611200	DEBrowser: interactive differential expression analysis and visualization tool for count data.	BMC Genomics	2019
29727662	Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling.	Cell	2018
32158910	Advanced 3D Analysis and Optimization of Single-Molecule FISH in Muscle.	Small Methods	2018
29932423	Synergistic assembly of human pre-spliceosomes across introns and exons.	eLife	2018
30451990	RNAi modulation of placental sFLT1 for the treatment of preeclampsia.	Nat Biotechnol	2018
30088967	MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct.	Nucleic Acid Therapeutics	2018
30415953	Higher-Order Organization Principles of Pre-translational mRNPs.	Mol Cell	2018
30184490	Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.	Cell Rep	2018
29432571	Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.	Nucleic Acids Res	2018
29549138	Corrigendum: and : new actors in 18S nonfunctional rRNA decay.	RNA	2018
27994090	A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and <i>N</i><sup>1</sup>-methyladenosine modification.	RNA	2017
28956756	and : new actors in 18S nonfunctional rRNA decay.	RNA	2017
28939845	FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia.	Scientific Reports	2017
28615073	CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.	Genome Biol	2017
27256383	Single Molecule Approaches in RNA-Protein Interactions.	Advances in Experimental Medicine and Biology	2016
28777949	Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides.	Cell	2016
27244240	Single molecule analysis reveals reversible and irreversible steps during spliceosome activation.	eLife	2016
26871635	Redefining the Translational Status of 80S Monosomes.	Cell	2016
26721685	Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals.	Science	2016
27315481	A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.	Cell	2016
26140592	Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides.	Cell	2015
25505164	An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments.	Nucleic Acids Research	2015
25784054	The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion.	Annu Rev Biochem	2015
25866926	Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation.	eLife	2015
25780196	Twenty years of technology.	RNA	2015
25734262	Spliceosomes.	Current Biology	2015
24616503	Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.	Proceedings of the National Academy of Sciences of the United States of America	2014
24442611	Endogenous U2Â·U5Â·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.	RNA	2014
24336223	Staufen1 senses overall transcript secondary structure to regulate translation.	Nature Structural and Molecular Biology	2014
24096052	RIPiT-Seq: a high-throughput approach for footprinting RNA:protein complexes.	Methods	2014
24530854	The spliceosome: disorder and dynamics defined.	Current Opinion in Structural Biology	2014
24854588	Post-transcriptional regulation of gene expression in innate immunity.	Nature Reviews Immunology	2014
23569281	Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site.	Proceedings of the National Academy of Sciences of the United States of America	2013
23907535	A long noncoding RNA mediates both activation and repression of immune response genes.	Science	2013
24075986	Alternative spliceosome assembly pathways revealed by single-molecule fluorescence microscopy.	Cell Reports	2013
24143176	Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.	PLoS One	2013
23929032	ASPeak: an abundance sensitive peak detection algorithm for RIP-Seq.		2013
23673320	Defining piRNA primary transcripts.	Cell Cycle	2013
23523368	An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.	Mol Cell	2013
23583177	Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope.	Cell Reports	2013
23084401	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	Cell	2012
30360293	The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus.	Cell	2012
22801503	Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.	Nature	2012