Author details

Full Name

Rudolph E Tanzi

Affiliation

ORCID

Career Start Year

1983

Papers

504

H Index

126

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37292658	Endogenous recapitulation of Alzheimer's disease neuropathology through human 3D direct neuronal reprogramming.	bioRxiv	2023
37601062	Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.	Front Pharmacol	2023
37749326	APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFÎ²-mediated checkpoints.	Nat Immunol	2023
37667052	SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).	Nat Immunol	2023
37990786	Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology.		2023
37723351	Author Correction: SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).	Nat Immunol	2023
37986905	PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.		2023
37901842	Accelerating the in vitro emulation of Alzheimer's disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model.		2023
37721455	A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Alzheimer's Disease Treatment.		2023
37794492	Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.	Genome Med	2023
37713312	Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice.		2023
37712902	Bioluminescence Imaging with Functional Amyloid Reservoirs in Alzheimer's Disease Models.		2023
37972387	Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice.		2023
37620442	Infiltrating CD8 T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model.		2023
37689059	Irisin reduces amyloid-Î² by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.		2023
37283269	Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.		2023
36585781	A comparison between similarity matrices for principal component analysis to assess population stratification in sequenced genetic data sets.	Brief Bioinform	2023
36642841	The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models.		2023
37461624	Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.	medRxiv	2023
36703235	The neuroimmune axis of Alzheimer's disease.		2023
36748337	Adult neurogenesis in Alzheimer's disease.		2023
37120095	Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPÎ² levels in cerebrospinal fluid and 2D/3D cell culture models.		2023
36736288	Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance.		2023
37042072	Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a Î³-Secretase Modulator.	Ann Neurol	2023
37520559	Optimizing animal models of autoimmune encephalitis using active immunization.		2023
35084109	Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease.	Alzheimers Dement	2022
35388126	Author Correction: The neuronal-specific isoform of BIN1 regulates Î²-secretase cleavage of APP and AÎ² generation in a RIN3-dependent manner.	Scientific Reports	2022
35760872	Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation.	Nature Metabolism	2022
35577511	Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial.	J Neurol Neurosurg Psychiatry	2022
36213537	Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease.	Acta Pharmaceutica Sinica B	2022
35813951	Most Pathways Can Be Related to the Pathogenesis of Alzheimer's Disease.	Front Aging Neurosci	2022
35728383	Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.	Phytomedicine	2022
35919434	Epitope alteration by small molecules and applications in drug discovery.	Chemical Science	2022
35918447	PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk.	Scientific Reports	2022
36418293	Enhanced activity of Alzheimer disease-associated variant of protein kinase CÎ± drives cognitive decline in a mouse model.	Nat Commun	2022
35977543	Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.	Immunity	2022
35401082	Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer's Disease.	Frontiers in Neuroscience	2022
36479795	Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias.	Alzheimers Dement	2022
34160128	Plasma IL-12/IFN-Î³ axis predicts cognitive trajectories in cognitively unimpaired older adults.	Alzheimers Dement	2022
35333038	Rapid Biomarker Screening of Alzheimer's Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy.	ACS Nano	2022
34854884	Gut microbiota-driven brain AÎ² amyloidosis in mice requires microglia.	Journal of Experimental Medicine	2022
35248531	Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models.	Journal of Biological Chemistry	2022
35026040	Primary prevention recommendations to reduce the risk of cognitive decline.	Alzheimers Dement	2022
35202705	Alzheimer's disease amyloid-Î² pathology in the lens of the eye.	Experimental Eye Research	2022
35142036	Reply to Neupane etÂ al.: Replication study of AD-associated rare variants.	Alzheimers Dement	2022
35241726	The neuronal-specific isoform of BIN1 regulates Î²-secretase cleavage of APP and AÎ² generation in a RIN3-dependent manner.	Scientific Reports	2022
34417591	Exercise hormone irisin is a critical regulator of cognitive function.	Nature Metabolism	2021
33860595	Molecular imaging of NAD -dependent deacetylase SIRT1 in the brain.	Alzheimer's and Dementia	2021
33589649	In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss.	Scientific Reports	2021
34286713	Patterning of interconnected human brain spheroids.	Lab on a Chip	2021