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Author Details

James Koropatnick
Western University, Lawson Health Research Institute
1975
120
37
PMIDPaper TitleJournal TitlePublished Year
36068918Inducing mismatch repair deficiency sensitizes immune-cold neuroblastoma to anti-CTLA4 and generates broad anti-tumor immune memory.Mol Ther2023
35008676TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer.Int J Mol Sci2021
33584650Reduced CD5 on CD8<sup>+</sup> T Cells in Tumors but Not Lymphoid Organs Is Associated With Increased Activation and Effector Function.Front Immunol2021
32178827DIY: Visualizing the immune landscape of tumors using transcriptome and methylome data.Methods Enzymol2020
32081948Hepcidin-mediated Iron Regulation in P19 Cells is Detectable by Magnetic Resonance Imaging.Sci Rep2020
32076794miRNA-5119 regulates immune checkpoints in dendritic cells to enhance breast cancer immunotherapy.Cancer Immunol Immunother2020
31943150CD5 blockade enhances ex vivo CD8<sup>+</sup> T cell activation and tumour cell cytotoxicity.Eur J Immunol2020
31594465miR-149-3p reverses CD8<sup>+</sup> T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells.Open Biol2019
29061656Synergistic Antiproliferative Activity of the RAD51 Inhibitor IBR2 with Inhibitors of Receptor Tyrosine Kinases and Microtubule Protein.J Pharmacol Exp Ther2018
30345081TdIF1: a putative oncogene in NSCLC tumor progression.Signal Transduct Target Ther2018
30288365Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy.Oncoimmunology2018
29364966Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines.PLoS One2018
27856600TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding.Clin Cancer Res2017
29062467Correction: COTI-2, a novel small molecule that is active against multiple human cancer cell lines <i>in vitro</i> and <i>in vivo</i>.Oncotarget2017
28789683Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice.Crit Care2017
26959114Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.Oncotarget2016
26429639Synergistic cytotoxicity against human tumor cell lines by oncolytic adenovirus dl1520 (ONYX-015) and melphalan.Tumori2016
26472449Non-Covalently Functionalized of Single-Walled Carbon Nanotubes by DSPE-PEG-PEI for SiRNA Delivery.Methods Mol Biol2016
27150056COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo.Oncotarget2016
27290740From Solo in the Silo to Strategic Training Programs.CBE Life Sci Educ2016
25741641Evaluating the effectiveness of cancer drug sensitization in vitro and in vivo.J Vis Exp2015
26579709IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.PLoS One2015
26087398siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine.Oncotarget2015
23942307Vaccinia virus outperforms a panel of other poxviruses as a potent oncolytic agent for the control of head and neck squamous cell carcinoma cell lines.Intervirology2014
25216445Single-walled carbon nanotubes noncovalently functionalized with lipid modified polyethylenimine for siRNA delivery in vitro and in vivo.Bioconjug Chem2014
24974076BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.Mol Oncol2014
24784564Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin.Oncotarget2014
24884532Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy.J Transl Med2014
24509175Targeted siRNA silencing of indoleamine 2, 3-dioxygenase in antigen-presenting cells using mannose-conjugated liposomes: a novel strategy for treatment of melanoma.J Immunother2014
24424208Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma.Biomaterials2014
23836502Imaging tumor growth non-invasively using expression of MagA or modified ferritin subunits to augment intracellular contrast for repetitive MRI.Mol Imaging Biol2014
22870862Silencing IDO in dendritic cells: a novel approach to enhance cancer immunotherapy in a murine breast cancer model.Int J Cancer2013
23880315Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction.Am J Physiol Endocrinol Metab2013
23904762The epidemic of human papillomavirus and oropharyngeal cancer in a Canadian population.Curr Oncol2013
23663293Does HPV type affect outcome in oropharyngeal cancer?J Otolaryngol Head Neck Surg2013
23653877A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.Case Rep Oncol Med2013
23787421High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer.JAMA Otolaryngol Head Neck Surg2013
23481354Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality".Mol Ther Nucleic Acids2013
22066590Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.Biomacromolecules2012
23304554A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing.ISRN Oncol2012
22993321The Effects of N-acetylcysteine on ifosfamide efficacy in a mouse xenograft model.Anticancer Res2012
22911296Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.Arch Otolaryngol Head Neck Surg2012
22493344Reduction of tumorigenicity by placental extracts.Anticancer Res2012
22569013Ki-67 expression predicts radiotherapy failure in early glottic cancer.J Otolaryngol Head Neck Surg2012
22076949Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system.Head Neck2012
21375761Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?J Transl Med2011
21673071Combining small interfering RNAs targeting thymidylate synthase and thymidine kinase 1 or 2 sensitizes human tumor cells to 5-fluorodeoxyuridine and pemetrexed.J Pharmacol Exp Ther2011
20482488Antisense treatment in human prostate cancer and melanoma.Curr Cancer Drug Targets2010
18986763Enhancement of cytotoxicity of natural product drugs against multidrug resistant variant cell lines of human head and neck squamous cell carcinoma and breast carcinoma by tesmilifene.Cancer Lett2009
19723470Magnetic resonance imaging of cells overexpressing MagA, an endogenous contrast agent for live cell imaging.Mol Imaging2009
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Collaborators

University of Western Ontario
Co-authored papers 11
University of Western Ontario
Co-authored papers 11
University of Western Ontario
Co-authored papers 11
University of Western Ontario
Co-authored papers 9
Schulich School of Medicine & Dentistry, Western University
Co-authored papers 9
Schulich School of Medicine & Dentistry, Western University, Victoria Hospital
Co-authored papers 9
Schulich School of Medicine & Dentistry, Western University
Co-authored papers 6
Queen's University
Co-authored papers 6
Western University
Co-authored papers 5
Schulich School of Medicine and Dentistry, Western University
Co-authored papers 5
Schulich School of Medicine and Dentistry, University of Western Ontario
Co-authored papers 5
University of California at Davis School of Medicine
Co-authored papers 5
Gold Coast University Hospital
Co-authored papers 4
Institute of Nuclear Sciences "Vinca"-National Institute of the Republic of Serbia
Co-authored papers 4
University of Western Ontario
Co-authored papers 4
Schulich School of Medicine and Dentistry, University of Western Ontario
Co-authored papers 2
University of Toronto
Co-authored papers 2
Schulich School of Medicine and Dentistry, Western University
Co-authored papers 2
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Schulich School of Medicine and Dentistry, Western University
Co-authored papers 2
Western University
Co-authored papers 2
Western University
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
Schulich School of Medicine and Dentistry, Western University
Co-authored papers 2
University of California los angeles
Co-authored papers 2
Maastricht University
Co-authored papers 2
La Trobe Institute for Molecular Science, La Trobe University
Co-authored papers 2
Southern Illinois University School of Medicine
Co-authored papers 2
McMaster Immunology Research Centre, McMaster University
Co-authored papers 2
Ontario Institute for Cancer Research
Co-authored papers 2