Author details

Full Name

Ruth J F Loos

Affiliation

ORCID

Career Start Year

1996

Papers

545

H Index

129

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37474786	Persistent thinness and anorexia nervosa differ on a genomic level.	Eur J Hum Genet	2024
37736781	Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children.	Int J Obes (Lond)	2024
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
36302597	Genomic Disorders in CKD across the Lifespan.	J Am Soc Nephrol	2023
36216889	The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations.	Diabetologia	2023
36450930	Approaches to addressing the rise in obesity levels.	Nature Reviews Endocrinology	2023
37945903	Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.	Nat Genet	2023
38036650	Distilling causality between physical activity traits and obesity via Mendelian randomization.	Commun Med (Lond)	2023
38036523	Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.	Nat Commun	2023
37845825	New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium.		2023
37753190	PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies.	Curr Pollut Rep	2023
37662265	WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.	medRxiv	2023
37658231	Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts.	Hum Genet	2023
37648373	Ancestral diversity in lipoprotein(a) studies helps address evidence gaps.	Open Heart	2023
37904051	Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing.	Nat Genet	2023
37802043	Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.	Am J Hum Genet	2023
37794253	Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.	Nat Med	2023
37794109	Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review.		2023
37567789	Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation.	Nutr Metab Cardiovasc Dis	2023
37793214	Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations.		2023
37348055	Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.	Genetics	2023
37093654	Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification.	J Intern Med	2023
36778406	Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.	bioRxiv	2023
36778386	Structural variation across 138,134 samples in the TOPMed consortium.	Res Sq	2023
37337107	Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.	Nat Genet	2023
37148359	The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.	Diabetologia	2023
37334860	Life is pain: Fibromyalgia as a nexus of multiple liability distributions.	Am J Med Genet B Neuropsychiatr Genet	2023
36872133	Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.	Eur Urol	2023
37126548	The genetic determinants of recurrent somatic mutations in 43,693 blood genomes.	Sci Adv	2023
36802703	Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.	Circulation	2023
36747810	Structural variation across 138,134 samples in the TOPMed consortium.	bioRxiv	2023
37120605	Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.	Nat Commun	2023
36800959	Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins.		2023
36745605	Polygenic Scores Help Reduce Racial Disparities in Predictive Accuracy of Automated Type 1 Diabetes Classification Algorithms.		2023
37046083	Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.	Nature	2023
37425772	Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study.	medRxiv	2023
37546893	Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus.	medRxiv	2023
35263625	Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits.	Am J Hum Genet	2022
36372681	Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics.	Obesity (Silver Spring)	2022
36180445	Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes.	Nat Commun	2022
35909142	Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts.	Sci Rep	2022
35592775	The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.	Front Endocrinol (Lausanne)	2022
36042188	Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes.	Nat Commun	2022
35705101	The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.	Am J Hum Genet	2022
35652341	Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.	Hypertension	2022
35389749	Monogenic and Polygenic Contributions to QTc Prolongation in the Population.	Circulation	2022
35697829	Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.	Commun Biol	2022
35385311	Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.	Sci Adv	2022
36220816	Whole genome sequence analysis of blood lipid levels in >66,000 individuals.	Nat Commun	2022
36088317	Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations.	BMC Med Genomics	2022