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Author Details

Jianwei Che
Dana-Farber Cancer Institute
2005
56
22
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36823351Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.Nat Chem Biol2023
37088717Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity.Chembiochem2023
37018062HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development.ACS Chem Biol2023
36946421Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors.J Med Chem2023
37036171Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.J Med Chem2023
36970148Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives.RSC Med Chem2023
36921622Lactate regulates cell cycle by remodelling the anaphase promoting complex.Nature2023
36826833Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.J Med Chem2023
36347861Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells.Nat Commun2022
35597007Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.Eur J Med Chem2022
35450378Selective Macrocyclic Inhibitors of DYRK1A/B.ACS Med Chem Lett2022
36070758Exploring the target scope of KEAP1 E3 ligase-based PROTACs.Cell Chem Biol2022
36300789Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.Elife2022
36325394Covalent drugs targeting histidine - an unexploited opportunity?RSC Med Chem2022
36224199Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors.Nat Commun2022
34132782The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance.Blood2021
33753926Discovery and resistance mechanism of a selective CDK12 degrader.Nat Chem Biol2021
33915015Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.Angew Chem Int Ed Engl2021
34459829Correction: Fragment-based covalent ligand discovery.RSC Chem Biol2021
34458789Fragment-based covalent ligand discovery.RSC Chem Biol2021
34778341Latest Trend of Milk Derived Exosomes: Cargos, Functions, and Applications.Front Nutr2021
34795877Physicochemistry of Cereblon Modulating Drugs Determines Pharmacokinetics and Disposition.ACS Med Chem Lett2021
32532746Targeting <i>MET</i> Dysregulation in Cancer.Cancer Discov2020
33488961Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor.ACS Med Chem Lett2020
31935084Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.J Med Chem2020
32034073Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14-Mutant NSCLC.Clin Cancer Res2020
33275901Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.Cell2020
32916088Discovery of Covalent MKK4/7 Dual Inhibitor.Cell Chem Biol2020
32865967Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library.ACS Chem Biol2020
32502343Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.J Med Chem2020
32551010Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface.ACS Med Chem Lett2020
30705343Discovering highly selective and diverse PPAR-delta agonists by ligand based machine learning and structural modeling.Sci Rep2019
28850214A Rational Solid-State Synthesis of Supported Au-Ni Bimetallic Nanoparticles with Enhanced Activity for Gas-Phase Selective Oxidation of Alcohols.ACS Appl Mater Interfaces2017
27117272In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.J Otolaryngol Head Neck Surg2016
26650754Target the More Druggable Protein States in a Highly Dynamic Protein--Protein Interaction System.J Chem Inf Model2016
25766844LS-VISM: A software package for analysis of biomolecular solvation.J Comput Chem2015
26651948Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.Cell Host Microbe2015
25941465Identification of protein-ligand binding sites by the level-set variational implicit-solvent approach.J Chem Theory Comput2015
26005534(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.ACS Med Chem Lett2015
24516547Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns.PLoS One2014
24803860Heterogeneous Hydration of p53/MDM2 Complex.J Chem Theory Comput2014
23505345Evaluation of Hydration Free Energy by Level-Set Variational Implicit-Solvent Model with Coulomb-Field Approximation.J Chem Theory Comput2013
24900670Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.ACS Med Chem Lett2013
24277854Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Proc Natl Acad Sci U S A2013
23862933Phase-field approach to implicit solvation of biomolecules with Coulomb-field approximation.J Chem Phys2013
22346739Level-Set Variational Implicit-Solvent Modeling of Biomolecules with the Coulomb-Field Approximation.J Chem Theory Comput2012
22435989Chemical and biological properties of frequent screening hits.J Chem Inf Model2012
22096101Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.Science2011
20828158Expanding the diversity of allosteric bcr-abl inhibitors.J Med Chem2010
19150426A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.Mol Cell2009
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Collaborators

Nathanael S Gray
Harvard Medical School
Co-authored papers 21
James Andrew McCammon
Co-authored papers 8
Yingyao Zhou
Genomics Institute of the Novartis Research Foundation
Co-authored papers 4
Sirano Dhe-Paganon
Dana-Farber Cancer Institute
Co-authored papers 3
Jennifer L Harris
Co-authored papers 3
Kenneth D Westover
University of Texas Southwestern Medical Center
Co-authored papers 3
Pasi A J??nne
Dana-Farber Cancer Institute
Co-authored papers 2
Kenneth C Anderson
Dana Farber Cancer Institute
Co-authored papers 2
Peter K Sorger
Co-authored papers 2
Matthew G Rees
Co-authored papers 2
Milka Kostic
Dana-Farber Cancer Institute .
Co-authored papers 2
Thomas E Carey
Kresge Hearing Research Institute, University of Michigan ann arbor
Co-authored papers 2
Paul D De Jesus
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Cyril H Benes
Co-authored papers 1
David A Stein
College of Veterinary Medicine, Oregon State University
Co-authored papers 1
Nir Hacohen
Broad Institute of MIT and Harvard
Co-authored papers 1
Hong M Moulton
Carlson College of Veterinary Medicine, Oregon State University
Co-authored papers 1
Ghislain M C Bonamy
Prestige BioPharma Ltd
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
Nabeel Bardeesy
Massachusetts General Hospital
Co-authored papers 1
Alexander Karlas
Max Planck Institute for Infection Biology
Co-authored papers 1
Lewis C Cantley
Co-authored papers 1
Maria G Gonzalez
Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Sina Bavari
Co-authored papers 1
Doug Sanders
University of California san francisco
Co-authored papers 1
Abraham L Brass
University of Massachusetts Medical School
Co-authored papers 1
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 1
Erik Verschueren
University of California San Francisco
Co-authored papers 1
Megan L Shaw
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Release 1.2