Author details

Full Name

Aimee M Deaton

Affiliation

ORCID

Career Start Year

2006

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37492105	Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins.	Cell Genom	2023
36261593	Using human genetics to improve safety assessment of therapeutics.	Nature Reviews Drug Discovery	2023
37808681	Activin E is a TGFÎ² ligand that signals specifically through activin receptor-like kinase 7.		2023
35493704	Rare coding variants in DNA damage repair genes associated with timing of natural menopause.	Human Genetics and Genomics Advances	2022
35896531	Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.	Nature Communications	2022
34079032	Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry.	Sci Rep	2021
32590049	Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.	Regulatory Toxicology and Pharmacology	2020
30952858	Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.	Nature Communications	2019
30346593	Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence.	Toxicological Sciences	2019
30476138	Sequence variants associating with urinary biomarkers.	Hum Mol Genet	2019
30643255	A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.	Nat Genet	2019
31068582	Author Correction: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.	Nature Communications	2019
30504769	Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.	Nat Commun	2018
30271901	A rare missense variant in <i>NR1H4</i> associates with lower cholesterol levels.	Commun Biol	2018
27151365	MNase titration reveals differences between nucleosome occupancy and chromatin accessibility.	Nat Commun	2016
27304074	Enhancer regions show high histone H3.3 turnover that changes during differentiation.	Elife	2016
25908537	A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.	Nat Commun	2015
25082344	H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex.	eLife	2014
24578067	A unique DNA methylation signature defines a population of IFN-Î³/IL-4 double-positive T cells during helminth infection.	European Journal of Immunology	2014
25158628	Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming.	Nat Commun	2014
23837789	Multiplexed Illumina sequencing libraries from picogram quantities of DNA.	BMC Genomics	2013
21576262	CpG islands and the regulation of transcription.	Genes and Development	2011
21628449	Cell type-specific DNA methylation at intragenic CpG islands in the immune system.	Genome Research	2011
20393567	CpG islands influence chromatin structure via the CpG-binding protein Cfp1.	Nature	2010
19247482	A temporal threshold for formaldehyde crosslinking and fixation.	PLoS ONE	2009
18681894	Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless.	Genes to Cells	2008
16507360	A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization.	Mol Cell	2006