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Author Details

Alok R Singh
university of california san diego Department of Pediatrics, University of California
2007
23
16
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35664753A Novel Affinity Engineered Anti-CD47 Antibody With Improved Therapeutic Index That Preserves Erythrocytes and Normal Immune Cells.Front Oncol2022
32793389A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity.Cell Discov2020
31974273Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression.Mol Cancer Ther2020
31018997SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.Mol Cancer Ther2019
28817691Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.PLoS One2017
28137841Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.Proc Natl Acad Sci U S A2017
26938241PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.PLoS One2016
28881723Association of high microvessel α<sub>v</sub>β<sub>3</sub> and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.Oncotarget2016
27496136Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma.Mol Cancer Ther2016
25578041Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.Cancer Chemother Pharmacol2015
24162827PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.J Neurooncol2014
25425962Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12)â¿¿V-Ha-Ras transgenic mouse glioma model.Cancer Cell Int2014
24982421MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.J Biol Chem2014
25103499A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.Mol Cancer Res2014
24770346Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.PLoS One2014
24886428A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.BMC Immunol2014
24881819PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment.Exp Cell Res2014
22906884Purification and characterization of phosphoenolpyruvate carboxykinase from Raillietina echinobothrida, a cestode parasite of the domestic fowl.Parasitology2013
23045271Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.Oncogene2013
19756573Guanidine hydrochloride and urea-induced unfolding of Brugia malayi hexokinase.Eur Biophys J2010
18456347Molecular cloning and characterization of Plasmodium falciparum transketolase.Mol Biochem Parasitol2008
18499511Molecular cloning and characterization of Brugia malayi hexokinase.Parasitol Int2008
18001110DNA binding and topoisomerase II inhibitory activity of water-soluble ruthenium(II) and rhodium(III) complexes.Inorg Chem2007
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Van Andel Institute
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Children's National Hospital. Electronic address: .
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