Author details

Full Name

Daniel Martin Watterson

Affiliation

Northwestern University

ORCID

Career Start Year

1976

Papers

178

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35081152	Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology.	PLoS One	2022
35365657	PI3KÎ³ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.	Nat Commun	2022
32255549	First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.	Clin Pharmacol Drug Dev	2021
34302892	Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase.	Biochim Biophys Acta Mol Cell Res	2021
32781522	Involvement of p38 MAPK in Synaptic Function and Dysfunction.	Int J Mol Sci	2020
32672466	Correction to "A Selective and Brain Penetrant p38Î±MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction".	J Med Chem	2020
31104189	Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.	Geroscience	2019
30978288	A Selective and Brain Penetrant p38Î±MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.	J Med Chem	2019
30297392	p38Î± MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.	Proc Natl Acad Sci U S A	2018
30007168	An isoform-selective p38Î± mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease.	Neurobiol Aging	2018
29340047	Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma.	Oncotarget	2017
28381303	Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.	J Neuroinflammation	2017
26871438	MW151 Inhibited IL-1Î² Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.	PLoS One	2016
27974048	Selective suppression of the Î± isoform of p38 MAPK rescues late-stage tau pathology.	Alzheimers Res Ther	2016
25676389	Targeting human central nervous system protein kinases: An isoform selective p38Î±MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.	ACS Chem Neurosci	2015
26514773	Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.	Am J Physiol Gastrointest Liver Physiol	2015
26567572	Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton.	Biochemistry (Mosc)	2015
25886256	Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.	J Neuroinflammation	2015
25904805	Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.	J Neurosci	2015
24428690	Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation.	Am J Respir Cell Mol Biol	2014
25253854	An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.	J Neurosci	2014
25127391	Generation and behavior characterization of CaMKIIÎ² knockout mice.	PLoS One	2014
24789302	Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38Î± MAPK inhibitors.	J Neuroimmune Pharmacol	2014
23555849	Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.	PLoS One	2013
23840427	Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.	PLoS One	2013
23776455	Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase.	PLoS One	2013
23812255	Optimizing the use of CROs by academia and small companies.	Nat Rev Drug Discov	2013
22389662	A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells.	Transl Stroke Res	2012
23092534	The 6th drug discovery for neurodegeneration conference: an intensive course on translating research into drugs.	Expert Opin Drug Discov	2012
22817402	Mechanism of interleukin-1Î² induced-increase in mouse intestinal permeability in vivo.	J Interferon Cytokine Res	2012
22836255	Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.	J Neurosci	2012
20139351	Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.	Am J Respir Cell Mol Biol	2011
21733175	Microglial p38Î± MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (AÎ²).	J Neuroinflammation	2011
21126544	Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity.	Biochim Biophys Acta	2011
21095130	Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.	Bioorg Med Chem	2011
20809893	Application of NMR spectroscopy in medicinal chemistry and drug discovery.	Curr Top Med Chem	2011
20486807	Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures.	J Neurotrauma	2010
21152427	Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter.	PLoS One	2010
19268602	Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.	Bioorg Med Chem	2009
19876042	Targeting protein kinases in central nervous system disorders.	Nat Rev Drug Discov	2009
19661215	Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.	Drug Metab Dispos	2009
19796958	Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.	Bioorg Med Chem	2009
19569527	[Penetrating peptide inhibitor of the myosin light chain kinase suppresses hyperpermeability of vascular endothelium].	Ross Fiziol Zh Im I M Sechenova	2009
19501063	Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.	Brain Res	2009
19237746	Structural insight into nucleotide recognition by human death-associated protein kinase.	Acta Crystallogr D Biol Crystallogr	2009
18590543	Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.	J Neuroinflammation	2008
19090985	The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.	BMC Neurosci	2008
18678415	Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug.	J Neuroimmunol	2008
17079143	Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.	Bioorg Med Chem Lett	2007
17920148	Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.	Neurosci Res	2007

1 - 50 of 178

Erik J Soderblom

Center for Genomic and Computational Biology, Duke University

Career Start Year 2003

Number of shared co-authors 1

Rabah Soliymani

Meilahti Clinical Proteomics Core Facility, University of Helsinki

Career Start Year 1999

Number of shared co-authors 0

Giselle M Knudsen

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1999

Number of shared co-authors 0

Nicholas E Sherman

University of Virginia

Career Start Year 1994

Number of shared co-authors 0

Hee-Won Park

Kangwon National University College of Medicine

Career Start Year 1993

Number of shared co-authors 0

Vadim A Klenchin

University of Wisconsin-Madison

Career Start Year 1991

Number of shared co-authors 0

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 0

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 0

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 1

Richard S Johnson

University of Washington-Genome Sciences

Career Start Year 1987

Number of shared co-authors 0

Paul C Driscoll

The Francis Crick Institute

Career Start Year 1987

Number of shared co-authors 0

Rob Hooft van Huijsduijnen

Vrije Universiteit Amsterdam (VU)

Career Start Year 1987

Number of shared co-authors 0

Mark R Chance

Case Western Reserve University

Career Start Year 1986

Number of shared co-authors 0

Thomas A Neubert

Neuroscience Institute, NYU Grossman School of Medicine

Career Start Year 1986

Number of shared co-authors 0

Senyon Choe

Joint Center for Biosciences

Career Start Year 1986

Number of shared co-authors 0

David S Lawrence

University of North Carolina

Career Start Year 1984

Number of shared co-authors 0

Hediye Erdjument-Bromage

Neuroscience Institute, NYU Grossman School of Medicine

Career Start Year 1984

Number of shared co-authors 0

Lu-Yun Lian

Institute of Systems, The University of Liverpool

Career Start Year 1984

Number of shared co-authors 0

Brian T Chait

The Rockefeller University

Career Start Year 1984

Number of shared co-authors 0

Walter J Chazin

and Center for Structural Biology, Vanderbilt University

Career Start Year 1982

Number of shared co-authors 0

Jeffrey Shabanowitz

University of Virginia

Career Start Year 1980

Number of shared co-authors 0

Mary B Kennedy

California Institute of Technology

Career Start Year 1978

Number of shared co-authors 0

Peter J Munson

and Blood Institute, National Institutes of Health

Career Start Year 1978

Number of shared co-authors 0

Ravi Iyengar

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

Career Start Year 1976

Number of shared co-authors 0

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1974

Number of shared co-authors 1

Jack E Dixon

University of California

Career Start Year 1972

Number of shared co-authors 0

Robert J Fletterick

University of California San Francisco

Career Start Year 1971

Number of shared co-authors 1

Daniel R Storm

University of Washington

Career Start Year 1970

Number of shared co-authors 0

Susan S Taylor

University of California

Career Start Year 1969

Number of shared co-authors 0

Tony Hunter

Salk Institute for Biological Studies

Career Start Year 1968

Number of shared co-authors 0

row(s) 1 - 30 of 30

Linda J Van Eldik

University of Kentucky

Co-authored papers 71

Jacques Haiech

Groupement de recherche CNRS << Organoides >> (GDR2)1

Co-authored papers 23

Vladimir P Shirinsky

National Medical Research Center of Cardiology Named after Academician E.I. Chazov

Co-authored papers 15

Hantamalala Ralay Ranaivo

Ann and Robert H Lurie Children's Hospital of Chicago

Co-authored papers 13

Anastasia V Velentza

Ferring Research Institute Inc

Co-authored papers 11

Jeffrey M Craft

Center for Drug Discovery and Chemical Biology, Northwestern University

Co-authored papers 11

James P Schavocky

+Northwestern University

Co-authored papers 9

M Wainwright

Seattle Children's Hospital, University of Washington

Co-authored papers 8

Magdalena Zasadzki

Co-authored papers 6

Ian A Blair

Co-authored papers 2

Janet L Rossi

CNRS, Institut Agro, Universite de Bourgogne, Universite Bourgogne Franche-Comte

Co-authored papers 2

David M Steinhorn

USA Knoxville College of Nursing, University of Tennessee (L.C.K.)

Co-authored papers 2

Yves A Lussier

Center for Biomedical Informatics and Biostatistics, University of Arizona

Co-authored papers 1

Daniel R Clayburgh

Oregon Health & Science University

Co-authored papers 1

Mohammad Minhajuddin

University of Colorado School of Medicine

Co-authored papers 1

Daniel T Laskowitz

Duke University

Co-authored papers 1

Brian K Shoichet

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 1

Pratip Bhattacharya

The University of Texas MD Anderson Cancer Center

Co-authored papers 1

Nathan L Weinbren

Boston Children's Hospital

Co-authored papers 1

Susan E Crawford

NorthShore University HealthSystem, Research Institute, 1001 University Place

Co-authored papers 1

Yuzhi Jia

Feinberg School of Medicine, Northwestern University

Co-authored papers 1

Sookyong Koh

Children's Hospital Medical Center, University of Nebraska

Co-authored papers 1

Charu Venkatesan

Cincinnati Children's Hospital

Co-authored papers 1

Tadanori Tomita

Co-authored papers 1

Rintaro Hashizume

Co-authored papers 1

Jonathan D Cooper

Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield

Co-authored papers 1

Steven W Barger

University of Arkansas for Medical Sciences

Co-authored papers 1

MaryAnn Chrzaszcz

Institute of Nuclear Physics, Polish Academy of Sciences

Co-authored papers 1

Alexander Marks

University of Toronto

Co-authored papers 1

1 - 29

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