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Author Details

Michael T Laub
Massachusetts Institute of Technology
1998
112
49
PMIDPaper TitleJournal TitlePublished Year
37098061Marginal specificity in protein interactions constrains evolution of a paralogous family.Proc Natl Acad Sci U S A2023
37487082Toxic antiphage defense proteins inhibited by intragenic antitoxin proteins.Proc Natl Acad Sci U S A2023
37553375Author Correction: Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles.Nat Commun2023
37945946Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein homeostasis pathways.Nat Ecol Evol2023
37425788Toxic anti-phage defense proteins inhibited by intragenic antitoxin proteins.bioRxiv2023
34964191Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid.Mol Microbiol2022
35618312ssDNA is an allosteric regulator of the <i>C. crescentus</i> SOS-independent DNA damage response transcription activator, DriD.Genes Dev2022
35575547A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP.mBio2022
35725776The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA.Nat Microbiol2022
35395167Toxin-Antitoxin Systems as Phage Defense Elements.Annu Rev Microbiol2022
35361892Co-evolution of interacting proteins through non-contacting and non-specific mutations.Nat Ecol Evol2022
35361767Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles.Nat Commun2022
35686729Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity.Elife2022
36327213Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase.PLoS Biol2022
35924892The evolution of a counter-defense mechanism in a virus constrains its host range.Elife2022
36123438A functional selection reveals previously undetected anti-phage defence systems in the E. coli pangenome.Nat Microbiol2022
33125866Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa.Curr Biol2021
33771779Two-Component Signaling Systems Regulate Diverse Virulence-Associated Traits in Pseudomonas aeruginosa.Appl Environ Microbiol2021
33838104Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection.Mol Cell2021
34544284Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems.mBio2021
34242584Activation of a signaling pathway by the physical translocation of a chromosome.Dev Cell2021
34372701Evolution towards Virulence in a <i>Burkholderia</i> Two-Component System.mBio2021
34279217High-resolution, genome-wide mapping of positive supercoiling in chromosomes.Elife2021
33462496Characterizing the portability of phage-encoded homologous recombination proteins.Nat Chem Biol2021
32317317A Simple, Cost-Effective, and Robust Method for rRNA Depletion in RNA-Sequencing Studies.mBio2020
31937638A CRISPR Interference System for Efficient and Rapid Gene Knockdown in Caulobacter crescentus.mBio2020
33107822Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library.Elife2020
32857952ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.Mol Cell2020
32428482Constraints on the expansion of paralogous protein families.Curr Biol2020
32533919Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.Mol Cell2020
30559427Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.Nat Chem Biol2019
31645757Engineering orthogonal signalling pathways reveals the sparse occupancy of sequence space.Nature2019
31695193An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.Nature2019
31266875The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of <i>oriC</i>.mBio2019
30811478The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months.PLoS Biol2019
31164463Concerns about "Stress-Induced MazF-Mediated Proteins in Escherichia coli".mBio2019
31076737Author Correction: Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.Nat Chem Biol2019
30746496Unique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine Bacteria.mSystems2019
30692171Mechanisms of Resistance to the Contact-Dependent Bacteriocin CdzC/D in <i>Caulobacter crescentus</i>.J Bacteriol2019
29514271Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.Nucleic Acids Res2018
30220456A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication.Cell2018
30240739Constriction Rate Modulation Can Drive Cell Size Control and Homeostasis in C. crescentus.iScience2018
29861158Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis.Mol Cell2018
30212463Flexibility and constraint: Evolutionary remodeling of the sporulation initiation pathway in Firmicutes.PLoS Genet2018
28711280Unsupervised Extraction of Stable Expression Signatures from Public Compendia with an Ensemble of Neural Networks.Cell Syst2017
28489851Global analysis of double-strand break processing reveals in vivo properties of the helicase-nuclease complex AddAB.PLoS Genet2017
28154080Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.Science2017
28323618Contact-dependent killing by <i>Caulobacter crescentus</i> via cell surface-associated, glycine zipper proteins.Elife2017
28854358SMC Progressively Aligns Chromosomal Arms in Caulobacter crescentus but Is Antagonized by Convergent Transcription.Cell Rep2017
27288403Transcription rate and transcript length drive formation of chromosomal interaction domain boundaries.EMBO J2016
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Collaborators

Barrett S Perchuk
Massachusetts Institute of Technology, USA Howard Hughes Medical Institute
Co-authored papers 18
Orr Ashenberg
Co-authored papers 6
Benjamin X Wang
Co-authored papers 4
Harley H McAdams
Co-authored papers 4
Kyle C Cady
Massachusetts Institute of Technology
Co-authored papers 3
Mark Goulian
University of Pennsylvania
Co-authored papers 3
Sean Crosson
Co-authored papers 2
Katharina Ribbeck
Co-authored papers 2
Ian T Paulsen
Macquarie University
Co-authored papers 1
Alexei Savchenko
University of Toronto
Co-authored papers 1
Michelle Giglio
University of Maryland School of Medicine, Institute for Genome Sciences
Co-authored papers 1
Stephen H Friend
University of Oxford
Co-authored papers 1
Jonathan H Badger
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Patrice Menard
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
Co-authored papers 1
Kathleen M Chen
Princeton University
Co-authored papers 1
Kelsey M Wheeler
Co-authored papers 1
Job Dekker
University of Massachusetts Chan Medical School
Co-authored papers 1
Georgia Doing
Geisel School of Medicine at Dartmouth
Co-authored papers 1
Roman Sasik
Center for Computational Biology & Bioinformatics (CCBB), University of California
Co-authored papers 1
Jeremy D Selengut
Craig Venter Institute, 9704 Medical Center Drive
Co-authored papers 1
Balaji S Srinivasan
Co-authored papers 1
Fitnat H Yildiz
Co-authored papers 1
Jonathan Kimmelman
McGill University
Co-authored papers 1
Harmit S Malik
Fred Hutchinson Cancer Center
Co-authored papers 1
Casey S Greene
Co-authored papers 1
Claire M Fraser
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 1
Richard D Cummings
Co-authored papers 1
Deborah A Hogan
Geisel School of Medicine at Dartmouth
Co-authored papers 1
Daniel H Haft
National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 1
Jef D Boeke
Institute for Systems Genetics, NYU School of Medicine
Co-authored papers 1
Release 1.2