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Author Details

Jeffrey A Medin
Medical College of Wisconsin
1990
167
40
PMIDPaper TitleJournal TitlePublished Year
37455676A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice.J Gene Med2024
36323381Pathophysiological characterization of the Townes mouse model for sickle cell disease.Transl Res2023
37646042Novel anti-CD30/CD3 bispecific antibodies activate human T cells and mediate potent anti-tumor activity.Front Immunol2023
37231125Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency.Commun Biol2023
36816757Persistent hematopoietic polyclonality after lentivirus-mediated gene therapy for Fabry disease.Mol Ther Methods Clin Dev2023
36849293Corrigendum to "Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing" [2021 Sep-Oct;134(1-2):117-131].Mol Genet Metab2023
36830643Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions.Biomolecules2023
35902747rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis.Gene Ther2023
35298086Autologous, lentivirus-modified, T-rapa cell "micropharmacies" for lysosomal storage disorders.EMBO Mol Med2022
36083604Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency.J Inherit Metab Dis2022
35318678Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes.Lipids2022
34340879Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing.Mol Genet Metab2021
33547076Targeting oncoproteins with a positive selection assay for protein degraders.Sci Adv2021
33859303Sarcoma IL-12 overexpression facilitates NK cell immunomodulation.Sci Rep2021
33633114Lentivirus-mediated gene therapy for Fabry disease.Nat Commun2021
32474112Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.Biochim Biophys Acta Mol Cell Biol Lipids2020
32771993Discovery and validation of surface <i>N</i>-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets.J Immunother Cancer2020
30472209Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.Am J Pathol2019
31856922Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model.J Immunother Cancer2019
31186526Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.Lab Invest2019
31527255Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target.Proc Natl Acad Sci U S A2019
31128082Inherited monogenic defects of ceramide metabolism: Molecular bases and diagnoses.Clin Chim Acta2019
31056978An update on gene therapy for lysosomal storage disorders.Expert Opin Biol Ther2019
30539536Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells.Methods Mol Biol2019
30669243Lentiviral interleukin-10 gene therapy: Safety and questions.J Thorac Cardiovasc Surg2019
29167126Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.Am J Physiol Lung Cell Mol Physiol2018
30029679Acid ceramidase deficiency: Farber disease and SMA-PME.Orphanet J Rare Dis2018
30076069Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery.Cytotherapy2018
29937159A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice.J Thorac Cardiovasc Surg2018
29364266Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells.J Vis Exp2018
29379059Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.Sci Rep2018
29735266Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.Mol Metab2018
27915031Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.Biochim Biophys Acta Mol Basis Dis2017
28275553Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.BBA Clin2017
28342444Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.Am J Pathol2017
29321823Yin and Yang of mesenchymal stem cells and aplastic anemia.World J Stem Cells2017
29067886Sphingolipid pathway enzymes modulate cell fate and immune responses.Immunotherapy2017
28586264Practical considerations for chimeric antigen receptor design and delivery.Expert Opin Biol Ther2017
28683400Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.Redox Biol2017
28603745Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34<sup>+</sup> Cells for Correction of Fabry Disease.Mol Ther Methods Clin Dev2017
27866832Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues.Mol Genet Metab2017
27488725Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns.J Immunother2016
28116130Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.Future Sci OA2016
28536373Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques.Biomedicines2016
27618026Development of Novel Immunotherapies for Multiple Myeloma.Int J Mol Sci2016
27933304Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.Mol Ther Methods Clin Dev2016
27791045Roscoe Owen Brady: Passion for patients.Proc Natl Acad Sci U S A2016
27523577Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry.Bioanalysis2016
25804479Lentiviral vectors in cancer immunotherapy.Immunotherapy2015
26730268Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy.World J Stem Cells2015
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Collaborators

Daniel H Fowler
National Cancer Institute, National Institutes of Health
Co-authored papers 17
Roscoe O Brady
McLean Hospital
Co-authored papers 9
Shaf Keshavjee
University Health Network, University Health Network and University of Toronto
Co-authored papers 6
Christopher J Paige
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 6
Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 5
Richard R Drake
Medical University of South Carolina
Co-authored papers 5
Peter P Liu
Co-authored papers 4
Yunee Kim
University of Toronto
Co-authored papers 4
Vladimir Ignatchenko
Margaret Cancer Center
Co-authored papers 3
Yoko Kosaka
Oregon Health & Science University
Co-authored papers 3
Urban Emmenegger
Odette Cancer Centre
Co-authored papers 3
Raymond S Lance
Washington State University Elson S. Floyd College of Medicine
Co-authored papers 3
Gangjian Qin
University of Alabama at Birmingham, 1670 University Boulevard
Co-authored papers 3
Julius O Nyalwidhe
Eastern Virginia Medical School
Co-authored papers 3
Oliver J Semmes
Eastern Virginia Medical School
Co-authored papers 3
Fei-Fei Liu
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 2
Sarah Elschenbroich
Ontario Cancer Institute, University Health Network
Co-authored papers 2
Anthony O Gramolini
University of Toronto, University Avenue
Co-authored papers 2
Wei Shi
Research Institute, Princess Margaret Cancer Centre
Co-authored papers 2
Neil E Fleshner
University of Toronto
Co-authored papers 2
Dean A Troyer
Eastern Virginia Medical School
Co-authored papers 2
Thomas K Waddell
Toronto General Hospital
Co-authored papers 2
Lori J West
University of Alberta
Co-authored papers 2
Chandramohan Chitraju
Co-authored papers 2
Alex Ignatchenko
European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 2
Irina Kalatskaya
EMD Serono Research & Development Institute, Inc. (an affiliate of Merck KGaA)
Co-authored papers 1
Kevin G Becker
National Institute on Aging, National Institutes of Health
Co-authored papers 1
Razqallah Hakem
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 1
Pramod K Mistry
Co-authored papers 1
James E Bradner
Co-authored papers 1
Release 1.2