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Author Details

Till Milde
Hopp Children's Cancer Center Heidelberg (KiTZ)
1998
131
48
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37944912Pediatric low-grade glioma: State-of-the-art and ongoing challenges.Neuro Oncol2024
35977048BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.Neuro Oncol2023
37656187Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.Acta Neuropathol2023
37999877Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.J Neurooncol2023
37783879Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells.J Neurooncol2023
37738646Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation.Neuro Oncol2023
37501103Mitochondrial DNA mutations in Medulloblastoma.Acta Neuropathol Commun2023
37500667MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.Nat Commun2023
36959034Corrigendum to 'Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry' [Eur J Cancer 180 (2023) 71-84].Eur J Cancer2023
370855393D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.Nat Commun2023
37183219Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.J Neurooncol2023
37379234Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.Neuro Oncol2023
37277823Group-specific cellular metabolism in Medulloblastoma.J Transl Med2023
37441736Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies.Clin Pharmacol Ther2023
37075810LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.Neuro Oncol2023
37364231Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry INFORM.JCO Precis Oncol2023
37093271Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.Acta Neuropathol2023
36786841Correction to: Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.Acta Neuropathol2023
36715306Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than 2 subgroups.Neuro Oncol2023
36542877Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry.Eur J Cancer2023
36437415Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.Acta Neuropathol2023
36871657Cerebellar Mutism Syndrome After Posterior Fossa Tumor Surgery in Children-A Retrospective Single-Center Study.World Neurosurg2023
36639156Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.J Immunother Cancer2023
36933012Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.Acta Neuropathol2023
36459208Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.Acta Neuropathol2023
35882450The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models.Neuro Oncol2023
35012690Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival.Acta Neuropathol Commun2022
35565313Infants and Newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB Registry: A Unique and Challenging Population.Cancers (Basel)2022
36575299Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM.NPJ Precis Oncol2022
35159116Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models.Cancers (Basel)2022
35158947The Current Landscape of Targeted Clinical Trials in Non-WNT/Non-SHH Medulloblastoma.Cancers (Basel)2022
35158738Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study.Cancers (Basel)2022
32822486Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.Neuro Oncol2021
33879448Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas.Cancer Discov2021
33484663Predisposition to cancer in children and adolescents.Lancet Child Adolesc Health2021
33860896Current recommendations for cancer surveillance in Gorlin syndrome: a report from the SIOPE host genome working group (SIOPE HGWG).Fam Cancer2021
34885186SIOP PNET5 MB Trial: History and Concept of a Molecularly Stratified Clinical Trial of Risk-Adapted Therapies for Standard-Risk Medulloblastoma.Cancers (Basel)2021
34545083Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.Nat Commun2021
34657224Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies.J Neurooncol2021
34536122GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.Acta Neuropathol2021
34417833PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.Acta Neuropathol2021
34503286Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma.Cancers (Basel)2021
34131743Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas.Neuro Oncol2021
34050933A Study of Regulatory Challenges of Pediatric Oncology Phase I/II Trial Submissions and Guidance on Protocol Development.Clin Pharmacol Ther2021
34373263The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets.Cancer Discov2021
33336421Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data.Neuropathol Appl Neurobiol2021
33472956Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma.Sci Transl Med2021
33479225Sarcoma classification by DNA methylation profiling.Nat Commun2021
32451331A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in <i>BRAF</i>-Driven Pediatric Low-Grade Glioma Cells.Mol Cancer Ther2020
31867747Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14.Neuropathol Appl Neurobiol2020
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Collaborators

Olaf Witt
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 91
Stefan M Pfister
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 87
David T W Jones
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 65
Andrey Korshunov
Institute of Pathology, University Hospital Heidelberg
Co-authored papers 59
Andreas von Deimling
Co-authored papers 53
Marcel Kool
Hopp Children's Cancer Center (KiTZ)
Co-authored papers 44
Felix Sahm
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 42
Dominik Sturm
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 32
Cornelis M van Tilburg
Co-authored papers 29
Peter Lichter
German Cancer Research Center (DKFZ)
Co-authored papers 28
Martin Sill
Co-authored papers 26
Andreas E Kulozik
Co-authored papers 26
David Capper
Charite University Medicine Berlin
Co-authored papers 26
Kristian W Pajtler
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University
Co-authored papers 26
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 24
Hendrik Witt
Co-authored papers 21
Marc Remke
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 20
Marina Ryzhova
N.N. Burdenko Neurosurgical Institute
Co-authored papers 20
Stefan Rutkowski
University Medical Center Hamburg-Eppendorf
Co-authored papers 19
Christel Herold-Mende
Co-authored papers 19
Ulrich Sch??ller
University Medical Center Hamburg-Eppendorf
Co-authored papers 18
Paul A Northcott
St Jude Children's Research Hospital
Co-authored papers 18
Nada Jabado
McGill University Health Centre (MUHC), Montreal Children's Hospital (MCH)
Co-authored papers 17
Natalie J??ger
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 17
Torsten Pietsch
Co-authored papers 16
Christof M Kramm
Co-authored papers 15
Andrea Wittmann
Co-authored papers 14
Guido Reifenberger
Heinrich Heine University
Co-authored papers 14
Elke Pfaff
Co-authored papers 13
Marc Zapatka
Co-authored papers 12
Release 1.2