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Author Details

Zhihua Li
Princess Margaret Cancer Centre, University Health Network
2000
41
26
PMIDPaper TitleJournal TitlePublished Year
36639200Single-cell profiling of multiple myeloma reveals molecular response to FGFR3 inhibitor despite clinical progression.Cold Spring Harb Mol Case Stud2023
32665698The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.Leukemia2021
33509009A phase-1 trial of linsitinib (OSI-906) in combination with bortezomib and dexamethasone for the treatment of relapsed/refractory multiple myeloma.Leuk Lymphoma2021
34732728Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression.Nat Commun2021
28492226Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.Nat Commun2017
25311528Differential regulation of FGFR3 by PTPN1 and PTPN2.Proteomics2015
26158521FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.Cell Death Dis2015
24994712Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.Cancer Res2014
23355037An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol2013
23968501Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.J Med Chem2013
23810672A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.Bioorg Med Chem2013
21220410The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence.Mol Pharmacol2011
21788134Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.Bioorg Med Chem Lett2011
21632854Molecular target characterization and antimyeloma activity of the novel, insulin-like growth factor 1 receptor inhibitor, GTx-134.Clin Cancer Res2011
21618433Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.ChemMedChem2011
21189385Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia.J Clin Oncol2011
20360469Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma.Blood2010
20505154Effect of noncompetitive proteasome inhibition on bortezomib resistance.J Natl Cancer Inst2010
19805681Spontaneous remission in a patient with t(4;14) translocation multiple myeloma.J Clin Oncol2009
19901323Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition.Proc Natl Acad Sci U S A2009
18271526Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.J Proteome Res2008
17255285The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.Clin Cancer Res2007
17568814Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution.Leukemia2007
17332241Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma.Blood2007
16467200The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells.Blood2006
16849642MIP-1alpha (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma.Blood2006
15761022Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma.Blood2005
15598814CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.Blood2005
15126369Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo.Cancer Res2004
15381729The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades.J Exp Med2004
14871245Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma.Br J Haematol2004
12907145RU486-inducible retrovirus-mediated caspase-3 overexpression is cytotoxic to bcl-xL-expressing myeloma cells in vitro and in vivo.Mol Ther2003
14692533Improved therapeutic outcome following combination immunogene vaccination therapy in murine myeloma.Leuk Lymphoma2003
14502228A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer.Cancer Gene Ther2003
11999572Antigenic open reading frames from HHV-8 are present in multiple myeloma patients and normal individuals at similar frequency.Leuk Lymphoma2002
12200383A molecular compendium of genes expressed in multiple myeloma.Blood2002
12393593Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance.Blood2002
11477456Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: preclinical studies in myeloma.Cancer Gene Ther2001
11368448Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma--a phase 1 study.Leukemia2001
11290605The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells.Blood2001
10648414Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis.Blood2000
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Collaborators

Princess Margaret Cancer Centre, University Health Network
Co-authored papers 33
Co-authored papers 20
Princess Margaret Cancer Centre
Co-authored papers 8
Co-authored papers 7
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
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Hospital for Sick Children, University of Toronto
Co-authored papers 3
Hospital for Sick Children
Co-authored papers 3
Center for Cancer Research, National Cancer Institutes, National Institutes of Health
Co-authored papers 3
University of Toronto
Co-authored papers 3
University of Toronto
Co-authored papers 2
Hospital for Sick Children
Co-authored papers 2
Princess Margaret Cancer Centre
Co-authored papers 2
Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
University of Toronto
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 1
Co-authored papers 1
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 1
Princess Margaret Cancer Centre
Co-authored papers 1
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 1
University of Waterloo, University Avenue West
Co-authored papers 1
Toronto General Hospital, University Health Network, University of Toronto
Co-authored papers 1
University of St Andrews
Co-authored papers 1
Sunnybrook Research Institute, University of Toronto
Co-authored papers 1
West Virginia University
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Schroeder Arthritis Institute
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University of California los angeles
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Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1