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Author Details

Dieter Willbold
Institute of Physical Biology, Heinrich Heine University Dusseldorf
1993
335
44
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36529991Differentiation of subnucleus-sized oligomers and nucleation-competent assemblies of the Aβ peptide.Biophys J2023
37759704The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.Biomolecules2023
37668563Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis.Psychiatry Clin Neurosci2023
37609390Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease.Heliyon2023
37973869Cryo-EM of Aβ fibrils from mouse models find tg-APP<sub>ArcSwe</sub> fibrils resemble those found in patients with sporadic Alzheimer's disease.Nat Neurosci2023
37189613Oral Treatment with d-RD2RD2 Impedes Early Disease Mechanisms in SOD1*G93A Transgenic Mice but Does Not Prolong Survival.Biomedicines2023
36986663The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses.Pharmaceutics2023
37238187Development and Implementation of an Internal Quality Control Sample to Standardize Oligomer-Based Diagnostics of Alzheimer's Disease.Diagnostics (Basel)2023
36889654Evaluation of the <sup>18</sup>F-labeled analog of the therapeutic all-D-enantiomeric peptide RD2 for amyloid β imaging.Eur J Pharm Sci2023
36480084Residue alterations within a conserved hydrophobic pocket influence light, oxygen, voltage photoreceptor dark recovery.Photochem Photobiol Sci2023
36653015Atomic Resolution Insights into pH Shift Induced Deprotonation Events in LS-Shaped Aβ(1-42) Amyloid Fibrils.J Am Chem Soc2023
36647580Discovery of All-d-Peptide Inhibitors of SARS-CoV-2 3C-like Protease.ACS Chem Biol2023
36768484Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies.Int J Mol Sci2023
36732520Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool.NPJ Parkinsons Dis2023
35203649Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein.Biomedicines2022
35584626Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo.Cell Rep Med2022
35674432A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant.J Virol2022
35580288Interaction of Therapeutic d-Peptides with Aβ42 Monomers, Thermodynamics, and Binding Analysis.ACS Chem Neurosci2022
35501361Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin.Nat Commun2022
35831316The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.Nat Commun2022
35631367Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold.Pharmaceuticals (Basel)2022
35484235True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins.Nat Struct Mol Biol2022
35655068Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting.NPJ Parkinsons Dis2022
36445153Characteristics of the GlnH and GlnX Signal Transduction Proteins Controlling PknG-Mediated Phosphorylation of OdhI and 2-Oxoglutarate Dehydrogenase Activity in Corynebacterium glutamicum.Microbiol Spectr2022
36037966Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation.J Biol Chem2022
36358937Structure and Dynamics of Human Chemokine CCL16-Implications for Biological Activity.Biomolecules2022
35889050Riboflavin, a Potent Neuroprotective Vitamin: Focus on Flavivirus and Alphavirus Proteases.Microorganisms2022
36012107CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain.Int J Mol Sci2022
35917476Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy.J Am Chem Soc2022
36252819Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochem Int2022
35187076A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main Protease.Front Mol Biosci2022
35204656Inhibition of Polyglutamine Misfolding with D-Enantiomeric Peptides Identified by Mirror Image Phage Display Selection.Biomolecules2022
35327661Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.Biomolecules2022
34356681Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria.Biomolecules2021
33621443Structural determinants underlying the adduct lifetime in the LOV proteins of Pseudomonas putida.FEBS J2021
33870341Rapid <sup>18</sup>F-labeling via Pd-catalyzed S-arylation in aqueous medium.Chem Commun (Camb)2021
33667547Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.J Biol Chem2021
33805709A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model.Molecules2021
33661906In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases.PLoS One2021
34921141Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses.Transl Psychiatry2021
35053295Correction: Freischem et al. Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. <i>Biomolecules</i> 2021, <i>11</i>, 1057.Biomolecules2021
34380771The <i>Uppsala APP</i> deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.Sci Transl Med2021
34671235Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography.Front Neurosci2021
34637790Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction.J Biol Chem2021
34695709Histamine H<sub>3</sub> receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation.Bioorg Med Chem2021
34572348Sex-Related Motor Deficits in the Tau-P301L Mouse Model.Biomedicines2021
34685992Promising Natural Compounds against Flavivirus Proteases: Citrus Flavonoids Hesperetin and Hesperidin.Plants (Basel)2021
34739758All<i>-</i>d<i>-</i>Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors.J Med Chem2021
34068686The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL<sup>pro</sup> In Vitro.Viruses2021
34096600An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.Nucleic Acids Res2021
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Collaborators

Gunnar F Schr??der
Institute of Biological Information Processing (Structural Biochemistry)
Co-authored papers 8
Alexander K Buell
Institut fur Physikalische Biologie, Heinrich-Heine-Universitat Dusseldorf
Co-authored papers 8
Jan St??hr
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 7
Peter Bayer
University of Duisburg-Essen
Co-authored papers 4
Kai St??hler
Universitatsklinikum
Co-authored papers 3
Thomas J Begley
University at Albany
Co-authored papers 2
Christiaan Leeuwenburgh
Institute on Aging, University of Florida
Co-authored papers 2
Maria T Diaz-Meco
Co-authored papers 2
Marie-Jos??e H??bert
Universite de Montreal
Co-authored papers 2
Sovan Sarkar
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
Co-authored papers 2
Malene Hansen
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Kun-Liang Guan
University of California San Diego
Co-authored papers 2
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 2
Laura Santambrogio
Weill Cornell School of Medicine
Co-authored papers 2
Ioannis P Nezis
University of Warwick
Co-authored papers 2
Scott J Bultman
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Co-authored papers 2
Masashi Narita
Co-authored papers 2
Martin Ingelsson
Co-authored papers 2
Karin Przyklenk
Co-authored papers 2
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Svetlana Dokudovskaya
CNRS UMR9018, Institut Gustave Roussy, Universite Paris-Saclay
Co-authored papers 2
Hirotaka Watada
Co-authored papers 2
Sara Cherry
University of Pennsylvania
Co-authored papers 2
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 2
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 2
J. Wade Harper
Harvard Medical School
Co-authored papers 2
Nikolai V Gorbunov
Armed Forces Radiobiology Research Institute
Co-authored papers 2
Juan Fueyo
The University of Texas M.D. Anderson Cancer Center
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Lawrence H Boise
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Release 1.2