Author details

Full Name

Joan S Brugge

Affiliation

ORCID

Career Start Year

1975

Papers

262

H Index

111

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36925689	Synergistic combination therapy delivered via layer-by-layer nanoparticles induces solid tumor regression of ovarian cancer.		2023
37917586	Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids.	Cell Rep	2023
37626143	A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells.	Nat Commun	2023
37858468	Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues.		2023
36884217	Preclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors.	Clin Cancer Res	2023
34703030	Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts.	Oncogene	2022
35895872	AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer.	Cancer Discov	2022
35617956	A human breast atlas integrating single-cell proteomics and transcriptomics.	Dev Cell	2022
35264777	Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer.	Nat Rev Cancer	2022
34381210	Cycling cancer persister cells arise from lineages with distinct programs.	Nature	2021
33692550	Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids.	Nat Protoc	2021
33951110	Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy.	PLoS One	2021
34103421	Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.	Science Signaling	2021
33157050	Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines.	Cancer Cell	2020
32249764	Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages.	Nat Commun	2020
33378681	Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing.	Cell Rep	2020
32601199	Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.	Proc Natl Acad Sci U S A	2020
33256808	Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.	Breast Cancer Res	2020
33203854	Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07).	Nat Commun	2020
33199705	Transient commensal clonal interactions can drive tumor metastasis.	Nat Commun	2020
33128871	3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.	Mol Cell	2020
31097597	Role for polo-like kinase 4 in mediation of cytokinesis.	Proc Natl Acad Sci U S A	2019
31577930	United They Stand, Divided They Fall.		2019
30962322	Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo.	Mol Cancer Ther	2019
30799286	Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.	Cell Metab	2019
30679390	Combined MEK and BCL-2/X<sub>L</sub> Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.	Mol Cancer Ther	2019
30835824	Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.	Cancer	2019
29805077	Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.	Cancer Cell	2018
30440051	CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.	PLoS ONE	2018
28071763	Starved epithelial cells uptake extracellular matrix for survival.	Nat Commun	2017
28912235	Not just Salk.	Science	2017
28948214	Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.	NPJ Breast Cancer	2017
28848242	Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.	Nat Commun	2017
28446818	Metabolic changes promote rejection of oncogenic cells.	Nature Cell Biology	2017
28933153	Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues.	Nano Lett	2017
28566428	Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in <i>RAS</i> mutant cancers.	Sci Transl Med	2017
28649658	Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.	NPJ Breast Cancer	2017
29229826	Identification of cancer genes that are independent of dominant proliferation and lineage programs.	Proceedings of the National Academy of Sciences of the United States of America	2017
29239720	Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.	Elife	2017
27573169	Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.	Clin Cancer Res	2017
27913436	ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.	Cancer Res	2016
28416575	Moving Closer To Victory.	Cold Spring Harbor Symposia on Quantitative Biology	2016
26933062	Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.	Sci Signal	2016
27330058	The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.	Clin Cancer Res	2016
27133130	Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.	Cell Metab	2016
27216116	Coping with the metabolic stress of leaving home.	Cell Research	2016
27036968	Corrigendum: Chaperone-mediated autophagy degrades mutant p53.	Genes and Development	2016
27482544	Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.	JCI Insight	2016
27255161	A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for Î²-catenin.	Sci Rep	2016
26503052	Cancer: The enemy of my enemy is my friend.	Nature	2015