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Author Details

Brian Seed
Center for Computational and Integrative Biology, Massachusetts General Hospital
1980
155
81
PMIDPaper TitleJournal TitlePublished Year
31964813Intestinal microbes influence development of thymic lymphocytes in early life.Proc Natl Acad Sci U S A2020
29351322Influence of multiplicative stochastic variation on translational elongation rates.PLoS One2018
30332431GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.PLoS One2018
26699463Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.Proc Natl Acad Sci U S A2016
27926878The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.Cell Rep2016
24849652Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption.J Cell Sci2014
25246632Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.Mol Cell Biol2014
25007711Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.BMC Biochem2014
24278032Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.PLoS Genet2013
22086960PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.Nucleic Acids Res2012
23150065A high-content imaging workflow to study Grb2 signaling complexes by expression cloning.J Vis Exp2012
22875804Enhanced Tim3 activity improves survival after influenza infection.J Immunol2012
22217933STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.Bioorg Med Chem2012
21215314EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.Pharmacol Res2011
21915273Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.PLoS One2011
21737266C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.Bioorg Med Chem Lett2011
20056716Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions.FASEB J2010
20548287Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.Lab Invest2010
20513746Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.J Exp Med2010
20576578ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.Bioorg Med Chem2010
20581830The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.Nat Immunol2010
20414917Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.ChemMedChem2010
20399809Host-encoded reporters for the detection and purification of multiple enveloped viruses.J Virol Methods2010
19906719PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification.Nucleic Acids Res2010
19285117Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.Neuroscience2009
19896374Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.Bioorg Med Chem Lett2009
19700318O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.Bioorg Med Chem Lett2009
19500826Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules.J Allergy Clin Immunol2009
19170073Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.J Cell Physiol2009
18037161Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes.J Allergy Clin Immunol2008
19108745A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance.BMC Genomics2008
18641457Quantitation of autophagy by luciferase release assay.Autophagy2008
18353773A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.J Biol Chem2008
18411314Spinophilin and the immune synapse.J Cell Biol2008
18387192A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.Genome Biol2008
17142808ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.J Lipid Res2007
17537846General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.J Virol2007
16446073Expression cloning screen for modifiers of amyloid precursor protein shedding.Int J Dev Neurosci2006
16823376A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies.Nat Biotechnol2006
16751370CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.J Immunol2006
16924110Direct stimulation of T lymphocytes by immunosomes: virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules.Proc Natl Acad Sci U S A2006
15955840Identification of eosinophil lineage-committed progenitors in the murine bone marrow.J Exp Med2005
16116167B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.J Immunol2005
15999809Large-scale screens for cDNAs with in vivo activity.Novartis Found Symp2005
15963778PDZ domains and the politics of polarity in lymphocytes.Immunity2005
14691250Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.Proc Natl Acad Sci U S A2004
15263016Discs large (Dlg1) complexes in lymphocyte activation.J Cell Biol2004
15342367Differential transplantability of tumor-associated stromal cells.Cancer Res2004
15340423The knockout mouse project.Nat Genet2004
15075335The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.J Biol Chem2004
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Collaborators

Broad Institute of MIT and Harvard
Co-authored papers 19
Washington University School of Medicine
Co-authored papers 6
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 6
Co-authored papers 5
School of Pharmacy, East China University of Science and Technology
Co-authored papers 4
Center for Computational and Integrative Biology, Massachusetts General Hospital
Co-authored papers 3
University of Edinburgh
Co-authored papers 3
German Center for Neurodegenerative Diseases (DZNE) Munich
Co-authored papers 2
Medical University of Vienna
Co-authored papers 2
Harvard Stem Cell Institute, Harvard Medical School
Co-authored papers 2
Broad Institute of MIT and Harvard
Co-authored papers 1
Inc., Lehigh University
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
Kinderklinik und Kinderpoliklinik der Ludwig-Maximilians-Universitat Munchen
Co-authored papers 1
Co-authored papers 1
Wellcome Trust Sanger Institute
Co-authored papers 1
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Advanced Research Institute, Tokyo Medical and Dental University
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
University of Michigan ann arbor
Co-authored papers 1
University of Massachusetts Medical School
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
University of Virginia
Co-authored papers 1
ALS Therapy Development Institute
Co-authored papers 1
Center for Bioinformatics, University of Oslo
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
St. George's University Medical School
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
University of Washington School of Medicine
Co-authored papers 1