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Author Details

John A T Young
Roche Pharma
1990
107
45
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36896968Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.J Med Chem2023
36587899Discovery of a first-in-class orally available HBV cccDNA inhibitor.J Hepatol2023
36730407The NIH-led research response to COVID-19.Science2023
35677037Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B.Front Immunol2022
33242518Host RNA quality control as a hepatitis B antiviral target.Antiviral Res2021
32490326Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon-α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus.Hepatol Commun2020
33152278Accelerated Preclinical Paths to Support Rapid Development of COVID-19 Therapeutics.Cell Host Microbe2020
32882949The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription.Cells2020
32145089Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes.Hepatology2020
30664279Direct Inhibition of Hepatitis B e Antigen by Core Protein Allosteric Modulator.Hepatology2019
31827222Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts.Sci Rep2019
30365161PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization.Hepatology2019
29079285A novel orally available small molecule that inhibits hepatitis B virus expression.J Hepatol2018
29858079Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.Mol Ther Nucleic Acids2018
29369612Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection.ACS Infect Dis2018
28205569Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.Sci Rep2017
28339215Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.J Med Chem2017
28381571Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1.J Virol2017
28213165HBVcircle: A novel tool to investigate hepatitis B virus covalently closed circular DNA.J Hepatol2017
26906565Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages.Virol J2016
25822250Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.Nat Immunol2015
26355217BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.Cell Host Microbe2015
24405985Discovery of novel inhibitors of HIV-1 reverse transcriptase through virtual screening of experimental and theoretical ensembles.Chem Biol Drug Des2014
25297984CHD1 and CHD2 are positive regulators of HIV-1 gene expression.Virol J2014
25310595Sulfonation pathway inhibitors block reactivation of latent HIV-1.Virology2014
24760882Tumor suppressor cylindromatosis (CYLD) controls HIV transcription in an NF-κB-dependent manner.J Virol2014
24817247An integrated map of HIV-human protein complexes that facilitate viral infection.PLoS One2014
23719353Bringing it all together: big data and HIV research.AIDS2013
24204263ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter.PLoS Pathog2013
23954153Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.Cell Host Microbe2013
23617998ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication.Virol J2013
22511955Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment.PLoS One2012
23231773Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase.Virol J2012
22529944Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity.PLoS One2012
21423673HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.PLoS Pathog2011
22190034Global landscape of HIV-human protein complexes.Nature2011
22174672A receptor-based switch that regulates anthrax toxin pore formation.PLoS Pathog2011
21855102Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions.Virology2011
21283788Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion.PLoS Pathog2011
20027183Human host factors required for influenza virus replication.Nature2010
20823240Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor-ligand bridge protein.Proc Natl Acad Sci U S A2010
20484494Cellular transcription factor ZASC1 regulates murine leukemia virus transcription.J Virol2010
19901963Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis.Oncogene2010
19075066Efficient neutralization of antibody-resistant forms of anthrax toxin by a soluble receptor decoy inhibitor.Antimicrob Agents Chemother2009
19732789Receptors of anthrax toxin and cell entry.Mol Aspects Med2009
19478882Host cell factors in HIV replication: meta-analysis of genome-wide studies.PLoS Pathog2009
18350154Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.PLoS One2008
18854154Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.Cell2008
19008949The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment.PLoS Pathog2008
17245447The hr1 and fusion peptide regions of the subgroup B avian sarcoma and leukosis virus envelope glycoprotein influence low pH-dependent membrane fusion.PLoS One2007
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Collaborators

John Marlett
Salk Institute for Biological Studies
Co-authored papers 10
Sumit K Chanda
The Scripps Research Institute
Co-authored papers 10
John Naughton
Salk Institute for Biological Studies
Co-authored papers 10
Frederic D Bushman
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 7
Renate K??nig
Paul-Ehrlich-Institut
Co-authored papers 6
Lars Pache
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
Harold Varmus
Co-authored papers 5
Sourav Bandyopadhyay
University of California San Francisco
Co-authored papers 4
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 4
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 4
Alan D Frankel
University of California san francisco
Co-authored papers 3
Suchita Bhattacharyya
Feinberg School of Medicine, Northwestern University
Co-authored papers 3
Guido Steiner
Co-authored papers 3
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Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Daniel Elleder
Institute of Molecular Genetics of the Czech Academy of Sciences
Co-authored papers 3
Nirav Malani
University of Pennsylvania Perelman School of Medicine
Co-authored papers 3
Paul D De Jesus
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Tracy L Diamond
Merck & Co. Inc.
Co-authored papers 2
Anthony P Orth
Genomics Institute of the Novartis Research Foundation
Co-authored papers 2
Jason D Fernandes
University of California san francisco
Co-authored papers 2
Yingyao Zhou
Genomics Institute of the Novartis Research Foundation
Co-authored papers 2
Shoshannah L Roth
Cornell University
Co-authored papers 2
Arturo Diaz
La Sierra University
Co-authored papers 2
Iv??n D'Orso
University of Texas Southwestern Medical Center
Co-authored papers 2
Lara Manganaro
National Institute of Molecular Genetics, "Fondazione Romeo ed Enrica Invernizzi"
Co-authored papers 2
Joseph P Menetski
The Foundation for the National Institutes of Health
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Buu Tu
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Co-authored papers 2
Ghislain M C Bonamy
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