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Author Details

Martine F Roussel
St. Jude Children's Research Hospital
1977
232
87
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36318650Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo.Mol Cancer Ther2023
37910601Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.Sci Transl Med2023
37971169CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity.Cancer Res Commun2023
37020038Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.Oncogene2023
37183219Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.J Neurooncol2023
37333156CAR T-cell design dependent remodeling of the brain tumor immune microenvironment identify macrophages as key players that inhibit or promote anti-tumor activity.Res Sq2023
36786675Targeting protein folding in N-Myc-driven medulloblastoma.Mol Oncol2023
36765089Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.Nat Commun2023
36898329From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.Eur J Med Chem2023
35798383Primary cilia control translation and the cell cycle in medulloblastoma.Genes Dev2022
35709750Combination of Ribociclib and Gemcitabine for the Treatment of Medulloblastoma.Mol Cancer Ther2022
33320196Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery.Neuro Oncol2021
33744463LC-MS/MS method for quantitation of gemcitabine and its metabolite 2',2'-difluoro-2'-deoxyuridine in mouse plasma and brain tissue: Application to a preclinical pharmacokinetic study.J Pharm Biomed Anal2021
33629064Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.Neurooncol Adv2021
33509943Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.Cancer Res2021
34614283Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.Angew Chem Int Ed Engl2021
34042448Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.J Med Chem2021
33963961Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.J Neurooncol2021
34215733Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Nat Commun2021
33472956Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma.Sci Transl Med2021
32519082Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource.Acta Neuropathol2020
31788908Modeling pediatric medulloblastoma.Brain Pathol2020
31669383CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model.Eur J Pharm Sci2020
31948942An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.Cancer Res2020
31948065Preclinical Models of Craniospinal Irradiation for Medulloblastoma.Cancers (Basel)2020
30366006Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma.Int J Radiat Oncol Biol Phys2019
31399583MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.Nat Commun2019
31251562Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.ACS Chem Biol2019
31417200Women in cancer research.Nat Rev Cancer2019
30885981Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.Cancer Res2019
30487124A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.Clin Cancer Res2019
29339161A new genetically engineered mouse model of choroid plexus carcinoma.Biochem Biophys Res Commun2018
29909548Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.Acta Neuropathol2018
29880921Mouse medulloblastoma driven by CRISPR activation of cellular Myc.Sci Rep2018
29698863Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study.J Pharm Biomed Anal2018
29774125The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma.Oncotarget2018
29514916CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss.J Exp Med2018
29178021Epigenetic Drivers in Pediatric Medulloblastoma.Cerebellum2018
29301833Establishing a Preclinical Multidisciplinary Board for Brain Tumors.Clin Cancer Res2018
29170024Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.Bioorg Med Chem2018
28787124Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.ACS Chem Biol2017
28329683Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.Cell Rep2017
29103956mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.Dev Cell2017
29029386Exome sequencing analysis of murine medulloblastoma models identifies WDR11 as a potential tumor suppressor in Group 3 tumors.Oncotarget2017
28538182Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention.Cell Rep2017
28504719Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.Oncogene2017
28768907Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.JCI Insight2017
27050100Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.Cancer Cell2016
26518542Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.J Neurooncol2016
27178982Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.Elife2016
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Collaborators

Charles J Sherr
St. Jude Children's Research Hospital
Co-authored papers 96
Frederique Zindy
St. Jude Children's Research Hospital
Co-authored papers 43
Richard J Gilbertson
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 17
Olivier Ayrault
Institut Curie, PSL Research University, CNRS UMR, INSERM
Co-authored papers 15
Giles W Robinson
St. Jude Children's Research Hospital
Co-authored papers 14
Daisuke Kawauchi
University of California-San Diego
Co-authored papers 14
Anang A Shelat
St. Jude Children's Research Hospital
Co-authored papers 12
Amar Gajjar
St. Jude Children's Research Hospital
Co-authored papers 11
Alex Look
Dana-Farber Cancer Institute
Co-authored papers 11
Jerold E Rehg
St. Jude Children's Research Hospital
Co-authored papers 11
David W Ellison
St. Jude Children's Research Hospital
Co-authored papers 9
Stefan M Pfister
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 8
Brent A Orr
St. Jude Children's Research Hospital
Co-authored papers 8
Mei-Ling Kuo
Kaohsiung Chang Gung Memorial Hospital
Co-authored papers 8
Marcel Kool
Hopp Children's Cancer Center (KiTZ)
Co-authored papers 7
Paul A Northcott
St Jude Children's Research Hospital
Co-authored papers 7
Taosheng Chen
St. Jude Children's Research Hospital
Co-authored papers 7
Stanley Pounds
St. Jude Children's Research Hospital.
Co-authored papers 6
Peter J McKinnon
St. Jude Children's Research Hospital
Co-authored papers 6
Jason D Weber
Washington University School of Medicine
Co-authored papers 6
Willem den Besten
Genentech Inc.
Co-authored papers 5
Mary E Hatten
The Rockefeller University
Co-authored papers 5
Suzanne J Baker
Co-authored papers 5
Charles G Eberhart
Wilmer Eye Institute, Johns Hopkins Medical Institutions
Co-authored papers 5
Youngsoo Lee
University of Wisconsin-Madison School of Medicine and Public Health
Co-authored papers 5
Robert J Wechsler-Reya
Sanford Burnham Prebys Medical Discovery Institute
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Tamar Uziel
AbbVie Inc.
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Andrey Korshunov
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Release 1.2