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Author Details

Wendy Wei-Lynn Wong
Institute of Experimental Immunology, University of Zurich .
2000
54
31
PMIDPaper TitleJournal TitlePublished Year
37036227Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry.J Vis Exp2023
37524103Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases.Lancet Diabetes Endocrinol2023
36270981Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1.Cell Death Dis2022
34397140BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity.EMBO Rep2021
33546280Loss of cIAP1 in Endothelial Cells Limits Metastatic Extravasation through Tumor-Derived Lymphotoxin Alpha.Cancers (Basel)2021
31974356Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP.Cell Death Dis2020
31541082TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP.Cell Death Dis2019
31454332Caspase-8 modulates physiological and pathological angiogenesis during retina development.J Clin Invest2019
29743550Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.Cell Death Dis2018
29495595Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.Int J Mol Sci2018
27889570Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells.Gastroenterology2017
28106882Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.Cell Death Differ2017
28380356Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium.Cell Rep2017
28151480RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.Cell Death Dis2017
28842477Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.J Biol Chem2017
28654421Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.Elife2017
27904150Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.Immunol Cell Biol2017
26826208In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.J Biol Chem2016
26549703NET formation can occur independently of RIPK3 and MLKL signaling.Eur J Immunol2016
27622337Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.Cancer Cell2016
26859455Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.Cancer Cell2016
25301392Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.Diabetologia2015
28955803TNF induced inhibition of <i>Cirbp</i> expression depends on RelB NF-κB signalling pathway.Biochem Biophys Rep2015
26359988Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.Cell2015
26427759Response to Heard et al.EMBO J2015
26701909TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.Elife2015
25693118RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.Nat Commun2015
24497535cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.Blood2014
25443632TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.Elife2014
22327219IAPs limit activation of RIP kinases by TNF receptor 1 during development.EMBO J2012
22607974The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.Mol Cell2012
22365665Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.Immunity2012
22421966Cell death research, on an island girt by sea.Cell Death Differ2012
21455173Linear ubiquitination prevents inflammation and regulates immune signalling.Nature2011
21339290In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.J Biol Chem2011
20062539TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.PLoS One2010
20598143Characterization of the apoptotic response of human leukemia cells to organosulfur compounds.BMC Cancer2010
20356846Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.J Biol Chem2010
19927158RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.Cell Death Differ2010
19138581CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.Curr Biol2009
20038679Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment.J Cell Biol2009
19797318Another facet of ubiquitylation: death.J Mol Cell Biol2009
19815541TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.J Biol Chem2009
18425793Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.IUBMB Life2008
18606850TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.J Cell Biol2008
17575117Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma.Mol Cancer Ther2007
18022363IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.Cell2007
17072328Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.Oncogene2006
15374955Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis.Cancer Res2004
12747840Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression.Curr Biol2003
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Collaborators

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The University of Melbourne
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The University of Texas MD Anderson Cancer Center
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Lunenfeld-Tanenbaum Research Institute
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University of California Los Angeles
Co-authored papers 1
University of Texas Health San Antonio (UTHSA)
Co-authored papers 1
Institute of Virology, Medical Center - University of Freiburg
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Monash Biomedicine Discovery Institute, Monash University
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Queen's University
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University of Zurich
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University Medical Center Hamburg-Eppendorf
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