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Author Details

Stuart A Cook
1999
229
68
PMIDPaper TitleJournal TitlePublished Year
38032570Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy.JACC Heart Fail2024
35015342Therapeutic opportunities for senolysis in cardiovascular disease.2023
35365572Interleukin-11 drives human and mouse alcohol-related liver disease.Gut2023
37674806Sacubitril/valsartan versus valsartan in regressing myocardial fibrosis in hypertension: a prospective, randomized, open-label, blinded endpoint clinical trial protocol.Front Cardiovasc Med2023
37652022The penetrance of rare variants in cardiomyopathy-associated genes: A cross-sectional approach to estimating penetrance for secondary findings.Am J Hum Genet2023
37629170Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.2023
38054591Understanding interleukin 11 as a disease gene and therapeutic target.2023
36629985The Pathobiology of Interleukin 11 in Mammalian Disease is Likely Explained by its Essential Evolutionary Role for Fin Regeneration.2023
37431660Impact of Diabetes on Myocardial Fibrosis in Patients With Hypertension: The REMODEL Study.Circ Cardiovasc Imaging2023
35140116A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.J Am Soc Nephrol2022
35841888A high-resolution map of human RNA translation.Mol Cell2022
35654493Precision Phenotyping of Dilated Cardiomyopathy Using Multidimensional Data.J Am Coll Cardiol2022
35904853High-Resolution Digital Phenotypes From Consumer Wearables and Their Applications in Machine Learning of Cardiometabolic Risk Markers: Cohort Study.Journal of Medical Internet Research2022
35820507Vitamin B and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.Journal of Hepatology2022
36154167Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy.Circulation2022
36012165IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues.International Journal of Molecular Sciences2022
35806094Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.International Journal of Molecular Sciences2022
35992082IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.iScience2022
36057633Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.Nature Communications2022
35408908IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.International Journal of Molecular Sciences2022
35603595Markers of Focal and Diffuse Nonischemic Myocardial Fibrosis Are Associated With Adverse Cardiac Remodeling and Prognosis in Patients With Hypertension: The REMODEL Study.Hypertension2022
36470928Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.Nat Commun2022
34132780Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function.Cardiovascular Research2022
35317606Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis.Thyroid2022
34380661Moderate excess alcohol consumption and adverse cardiac remodelling in dilated cardiomyopathy.Heart2022
35135328Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome.Circulation Research2022
34873143Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study.Translational Psychiatry2021
36338161Lowering the Recommended Maximal Wall Thickness Threshold Improves Diagnostic Sensitivity in Asians With Hypertrophic Cardiomyopathy.JACC: Asia2021
32255186The remodelling index risk stratifies patients with hypertensive left ventricular hypertrophy.European Heart Journal Cardiovascular Imaging2021
33590875IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.Rheumatology2021
33685501Cardiovascular magnetic resonance predictors of heart failure in hypertrophic cardiomyopathy: the role of myocardial replacement fibrosis and the microcirculation.J Cardiovasc Magn Reson2021
34225778Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era.Genome Med2021
33677556Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23.Eur Heart J2021
34274268Prognostic Significance of Nonischemic Myocardial Fibrosis in Patients With Normal LV Volumes and Ejection-Fraction.JACC Cardiovasc Imaging2021
34108253Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.Science Translational Medicine2021
33462828Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload.Clinical and Experimental Pharmacology and Physiology2021
33658056Multiparametric exercise stress cardiovascular magnetic resonance in the diagnosis of coronary artery disease: the EMPIRE trial.Journal of Cardiovascular Magnetic Resonance2021
33500567Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies.Genet Med2021
33495596Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.Nat Genet2021
33046849Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited cardiac conditions.Genet Med2021
32592090Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload-Induced Cardiac Fibrosis in Mice.Journal of Cardiovascular Translational Research2021
33397952Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.Nature Communications2021
34570432Critical Conditions for Studying Interleukin-11 Signaling In Vitro and Avoiding Experimental Artefacts.Current Protocols2021
34461741Contribution of Noncanonical Splice Variants to <i>TTN</i> Truncating Variant Cardiomyopathy.Circ Genom Precis Med2021
34460321New Variant With a Previously Unrecognized Mechanism of Pathogenicity in Hypertrophic Cardiomyopathy.Circulation2021
34667238A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model.Scientific Reports2021
34503678Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy.Journal of the American College of Cardiology2021
34435951The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling.eLife2021
34651016Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.Frontiers in Molecular Biosciences2021
35242820A Systematic Quality Scoring Analysis to Assess Automated Cardiovascular Magnetic Resonance Segmentation Algorithms.Frontiers in Cardiovascular Medicine2021
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Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
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Brigham and Women's Hospital (Y.K.
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Harvard Medical School
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National Heart and Lung Institute, Imperial College London
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University of Cambridge
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British Heart Foundation Centre of Research Excellence, University of Glasgow
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Partners Healthcare Center for Personalized Genetic Medicine
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Duke-National University of Singapore
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Saint Joseph Hospital, Paris-Sorbonne University
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