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Author Details

Kevan M Shokat
University of California San Francisco
1987
391
115
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36197521A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability.Cancer Discov2023
37758692Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.Nat Commun2023
38060502Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.Anal Chem2023
37943662Protocol for performing and optimizing differential scanning fluorimetry experiments.STAR Protoc2023
37579045Direct Modulators of K-Ras-Membrane Interactions.ACS Chem Biol2023
38045405Selective activation of intracellular β1AR using a spatially restricted antagonist.bioRxiv2023
37495694Evolutionarily divergent mTOR remodels translatome for tissue regeneration.Nature2023
37494188mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching.Cell Rep2023
36759733A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF<sup>V600E</sup> colorectal tumors.Nat Cancer2023
36863607Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain.Mol Cell Proteomics2023
35167298Drugging the Next Undruggable KRAS Allele-Gly12Asp.J Med Chem2022
36480603IFITM proteins assist cellular uptake of diverse linked chemotypes.Science2022
36001446Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.J Am Chem Soc2022
36104566Brain-restricted mTOR inhibition with binary pharmacology.Nature2022
36103516Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.Sci Transl Med2022
35864332Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).Nat Chem Biol2022
36099883A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.Cancer Cell2022
36095197Tissue-restricted inhibition of mTOR using chemical genetics.Proc Natl Acad Sci U S A2022
36166818Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy.ACS Chem Biol2022
35314814KRAS is vulnerable to reversible switch-II pocket engagement in cells.Nat Chem Biol2022
35247925CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization.Mol Cancer Ther2022
34942634Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35332335Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35087237Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1.Oncogene2022
35234864Drugging the undruggable: Ross Cagan interviews Kevan Shokat.Dis Model Mech2022
34315870Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice.Nat Commun2021
33495306Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.Science2021
33791693Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.bioRxiv2021
33509943Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.Cancer Res2021
33636117Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes.Stem Cell Reports2021
34546793Dissecting the biology of mTORC1 beyond rapamycin.Sci Signal2021
34326236Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.Science2021
34127972Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.bioRxiv2021
32531271Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.Cancer Cell2020
31806641Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma.Cancer Res2020
31678994Betacellulin drives therapy resistance in glioblastoma.Neuro Oncol2020
33145412GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.ACS Cent Sci2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33069070The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells.Bioorg Med Chem2020
32645325The Global Phosphorylation Landscape of SARS-CoV-2 Infection.Cell2020
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
30636329Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates.Protein Sci2019
31638431p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin.FASEB J2019
31831640p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.Science2019
31557383Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins.Angew Chem Int Ed Engl2019
31343870A Bounty of New Challenging Targets in Oncology for Chemical Discovery.Biochemistry2019
30808819Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.Sci Signal2019
30827827A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.Cell Host Microbe2019
31138768KRAS<sup>G12C</sup> inhibition produces a driver-limited state revealing collateral dependencies.Sci Signal2019
30992425Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.Exp Mol Med2019
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Collaborators

William A Weiss
University of California san francisco
Co-authored papers 22
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 21
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 20
Rebecca S Levin
Howard Hughes Medical Institute, University of California San Francisco
Co-authored papers 13
Dorothea Fiedler
Leibniz Forschungsinstitut fur Molekulare Pharmakologie (FMP)
Co-authored papers 11
John D Gordan
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 9
Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 9
Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 9
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 9
Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 9
Jyoti Batra
J. David Gladstone Institutes
Co-authored papers 8
Mehdi Bouhaddou
J. David Gladstone Institutes
Co-authored papers 8
Martin L Sos
University of Cologne, Faculty of Medicine and University Hospital Cologne
Co-authored papers 8
Hannes Braberg
University of California San Francisco
Co-authored papers 7
Michael Shales
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 7
Natalia Jura
Cardiovascular Research Institute, University of California San Francisco
Co-authored papers 7
Margaret Soucheray
J. David Gladstone Institutes
Co-authored papers 7
Kirsten Obernier (CM4AI)
University of California San Francisco
Co-authored papers 7
Milka Kostic
Dana-Farber Cancer Institute .
Co-authored papers 7
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 7
Davide Ruggero
University of California San Francisco
Co-authored papers 7
Arthur Weiss
University of California san francisco
Co-authored papers 7
Arvin C Dar
Co-authored papers 7
Danish Memon
European Bioinformatics Institute
Co-authored papers 6
Joseph B Hiatt
Fred Hutchinson Cancer Center
Co-authored papers 6
Kliment A Verba
University of California, University of California San Francisco
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Frank McCormick
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Peter Walter
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Release 1.2