Author details

Full Name

Soumya S Ray

Affiliation

Lysosomal Therapeutics Inc.

ORCID

Career Start Year

1997

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
33290061	Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors.	J Med Chem	2020
29409752	Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors.	Bioorg Med Chem Lett	2018
30159405	Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations.	Commun Biol	2018
28074661	Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).	Expert Opin Ther Pat	2017
28435985	Elucidating the AÎ²42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data.	CNS Drugs	2017
27717544	Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.	Bioorg Med Chem Lett	2016
25801024	Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.	Cell Rep	2015
26320862	Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.	Chem Biol	2015
25998502	Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking.	Bioorg Med Chem Lett	2015
24695735	The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.	J Biol Chem	2014
24598103	Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.	J Biomol Screen	2014
23379419	Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S.	Biochemistry	2013
22335895	Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.	Bioorg Med Chem Lett	2012
22924508	Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design.	Future Med Chem	2012
22658960	Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1.	Anal Biochem	2012
22310229	Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.	Bioorg Med Chem Lett	2012
21961647	Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.	Biochemistry	2011
20232802	Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods.	J Med Chem	2010
20527929	Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.	Biochemistry	2010
17451229	Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease.	Biochemistry	2007
16537382	Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.	Proc Natl Acad Sci U S A	2006
15738401	Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.	Proc Natl Acad Sci U S A	2005
15068809	Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.	Mol Cell	2004
15079068	A possible therapeutic target for Lou Gehrig's disease.	Proc Natl Acad Sci U S A	2004
15109247	An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.	Biochemistry	2004
12471609	X-ray structure of an M. jannaschii DNA-binding protein: implications for antibiotic resistance in S. aureus.	Proteins	2003
11910018	Structural genomics: a pipeline for providing structures for the biologist.	Protein Sci	2002
12429091	Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor.	Structure	2002
11322189	An electrospray ionization mass spectrometry investigation of 1-anilino-8-naphthalene-sulfonate (ANS) binding to proteins.	J Am Soc Mass Spectrom	2001
9890925	Unfolding of Plasmodium falciparum triosephosphate isomerase in urea and guanidinium chloride: evidence for a novel disulfide exchange reaction in a covalently cross-linked mutant.	Biochemistry	1999
10211840	Disulfide engineering at the dimer interface of Lactobacillus casei thymidylate synthase: crystal structure of the T155C/E188C/C244T mutant.	Protein Sci	1999
10467131	Unusual stability of a multiply nicked form of Plasmodium falciparum triosephosphate isomerase.	Chem Biol	1999
9890931	Cavity-creating mutation at the dimer interface of Plasmodium falciparum triosephosphate isomerase: restoration of stability by disulfide cross-linking of subunits.	Biochemistry	1999
9291679	Metabolic enzymes as potential drug targets in Plasmodium falciparum.	Indian J Med Res	1997
9261072	Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design.	Structure	1997

1 - 35 of 35

Arthur O Zalevsky

University of California san francisco

Career Start Year 2015

Number of shared co-authors 2

Guillaume Poncet-Montange

Center for the Development of Therapeutics, Broad Institute of MIT & Harvard

Career Start Year 2007

Number of shared co-authors 1

Priyadarshini Jaishankar

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 2005

Number of shared co-authors 0

Sagar D Khare

The State University of New Jersey

Career Start Year 2003

Number of shared co-authors 2

Hao Fan

College of Biotechnology and Bioengineering, Zhejiang University of Technology

Career Start Year 2001

Number of shared co-authors 4

Jason E Gestwicki

Institute for Neurodegenerative Diseases, University of California San Francisco

Career Start Year 2000

Number of shared co-authors 1

Matthew P Jacobson

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1999

Number of shared co-authors 7

Nikolay V Dokholyan

Pennsylvania State University College of Medicine

Career Start Year 1998

Number of shared co-authors 2

Rodrigo J Carbajo

Oncology R&D

Career Start Year 1997

Number of shared co-authors 3

Shira Albeck

Weizmann Institute of Science

Career Start Year 1996

Number of shared co-authors 5

Orly Dym

Weizmann Institute of Science

Career Start Year 1995

Number of shared co-authors 5

Hualiang Jiang

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Career Start Year 1994

Number of shared co-authors 0

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 1

Giorgio Colombo

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Career Start Year 1993

Number of shared co-authors 0

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 0

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Career Start Year 1989

Number of shared co-authors 5

Brian K Shoichet

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1989

Number of shared co-authors 3

Gerhard Klebe

Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg

Career Start Year 1988

Number of shared co-authors 1

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 1

Yi-Liang Liu

National Chung Hsing University

Career Start Year 1988

Number of shared co-authors 0

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 6

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 2

Herman W T van Vlijmen

Leiden Academic Centre for Drug Research (LACDR), Leiden University

Career Start Year 1988

Number of shared co-authors 1

Piotr Cieplak

Sanford-Burnham-Prebys Medical Discovery Institute

Career Start Year 1987

Number of shared co-authors 0

Diane Joseph-McCarthy

Boston University

Career Start Year 1987

Number of shared co-authors 2

Christophe L M J Verlinde

University of Washington

Career Start Year 1984

Number of shared co-authors 2

Stefan Knapp

Institute of Pharmaceutical Chemistry, Goethe University

Career Start Year 1983

Number of shared co-authors 5

Ruben Abagyan

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

Career Start Year 1981

Number of shared co-authors 2

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 2

David Eisenberg

university of california los angeles

Career Start Year 1963

Number of shared co-authors 2

row(s) 1 - 30 of 30

Stephen K Burley

The State University of New Jersey

Co-authored papers 3

Jeffrey B Bonanno

Albert Einstein College of Medicine

Co-authored papers 3

Hua Chen

Co-authored papers 2

Guoshun He

Co-authored papers 2

Sameer Velankar

European Bioinformatics Institute

Co-authored papers 2

Simon J Boulton

The Francis Crick Institute

Co-authored papers 1

Raymond Y Huang

Brigham and Women's Hospital, Harvard Medical School

Co-authored papers 1

Anne R Bresnick

Albert Einstein College of Medicine

Co-authored papers 1

Christopher D Lima

Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center

Co-authored papers 1

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

Li Kai Wang

Sloan-Kettering Institute

Co-authored papers 1

Fred E Regnier

Co-authored papers 1

Valentin A Ilyin

Carnegie Mellon University Qatar

Co-authored papers 1

Narayanan Eswar

University of California at San Francisco

Co-authored papers 1

Seth A Darst

The Rockefeller University

Co-authored papers 1

John A Buglino

Sloan Kettering Institute

Co-authored papers 1

Subbiah Parthasarathy

New York University Grossman School of Medicine

Co-authored papers 1

John Alan Diehl

Case Western Reserve University School of Medicine

Co-authored papers 1

Jian-Sheng Jiang

Co-authored papers 1

Ken Auerbach

Co-authored papers 1

Ursula Pieper

University of California san francisco

Co-authored papers 1

Gregory A Petsko

Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University

Co-authored papers 1

Mark R Chance

Case Western Reserve University

Co-authored papers 1

Steven C Almo

Albert Einstein College of Medicine

Co-authored papers 1

Linda McMahan

Dana-Farber Cancer Institute

Co-authored papers 1

Marc Vidal

Blavatnik Institute, Harvard Medical School

Co-authored papers 1

1 - 26

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