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Author Details

Adam E Locke
2008
69
38
PMIDPaper TitleJournal TitlePublished Year
36807635Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.Nature2023
37034649Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.medRxiv2023
34115842Heterozygous variants of CLPB are a cause of severe congenital neutropenia.Blood2022
35654975A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.Nat Genet2022
35888728Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations in the Alpine CHRIS Cohort.Metabolites2022
35999217Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.Nat Commun2022
35939579Germline Mutations in <i>CIDEB</i> and Protection against Liver Disease.N Engl J Med2022
35551307Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.Nat Genet2022
35410376Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia.Nat Genet2022
36055244Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.Am J Hum Genet2022
36450978Common and rare variant associations with clonal haematopoiesis phenotypes.Nature2022
34662886Exome sequencing and analysis of 454,787 UK Biobank participants.Nature2021
33798444Association of structural variation with cardiometabolic traits in Finns.Am J Hum Genet2021
34115965Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals.Am J Hum Genet2021
33674754Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.Mol Psychiatry2021
33619501Genome-wide analysis in 756,646 individuals provides first genetic evidence that <i>ACE2</i> expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.medRxiv2021
34210852Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity.Science2021
34099068Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.Hum Genomics2021
33655273A catalog of associations between rare coding variants and COVID-19 outcomes.medRxiv2021
34855475Genetic and functional evidence links a missense variant in <i>B4GALT1</i> to lower LDL and fibrinogen.Science2021
32915782Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.PLoS Genet2020
31367044Exome sequencing of Finnish isolates enhances rare-variant association power.Nature2019
31686056Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power.Nature2019
31564431Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits.Am J Hum Genet2019
31039482Getting to precision psychopharmacology: Combining clinical and genetic information to predict fat gain from aripiprazole.Journal of Psychiatric Research2019
31160809Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Nat Genet2019
29273807Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Nat Genet2018
30218074Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans.Nat Commun2018
30297969Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.Nat Genet2018
29861106Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum.Am J Hum Genet2018
29481666Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.Hum Mol Genet2018
29549330Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Nat Genet2018
29549329Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Nat Genet2018
29279374Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.Proc Natl Acad Sci U S A2018
29360107Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.Sci Data2018
28146470Rare and low-frequency coding variants alter human adult height.Nature2017
28642257Interaction between the <i>FTO</i> gene, body mass index and depression: meta-analysis of 13701 individuals.Br J Psychiatry2017
28552196Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.Am J Hum Genet2017
28341696A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.Diabetes2017
29084231Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.PLoS Genet2017
29257133Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.Sci Data2017
27552965Across-cohort QC analyses of GWAS summary statistics from complex traits.Eur J Hum Genet2016
26833246New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.Nat Commun2016
26911676Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Hum Mol Genet2016
27120077Exome Sequencing of Familial Bipolar Disorder.JAMA Psychiatry2016
27398621The genetic architecture of type 2 diabetes.Nature2016
27571263Next-generation genotype imputation service and methods.Nat Genet2016
26366552Population genetic differentiation of height and body mass index across Europe.Nat Genet2015
25673413Genetic studies of body mass index yield new insights for obesity biology.Nature2015
25673412New genetic loci link adipose and insulin biology to body fat distribution.Nature2015
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Pat Macpherson Centre for Pharmacogenomics and Pharmacogenetics, University of Dundee
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King's College London
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London NorthWest Healthcare NHS Trust
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Imperial College London
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